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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Comprehensive characterization of bioactive phenols from new Brazilian superfruits by LC-ESI-QTOF-MS, and their ROS and RNS scavenging effects and anti-inflammatory activity

Texto completo
Autor(es):
Soares, Jackeline Cintra [1] ; Rosalen, Pedro Luiz [2] ; Lazarini, Josy Goldoni [2] ; Massarioli, Adna Prado [1] ; da Silva, Camila Fortunato [1] ; Nani, Bruno Dias [2] ; Franchin, Marcelo [2] ; de Alencar, Severino Matias [3, 1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind Food & Nutr, Padua Dias Ave, POB 9, BR-13418900 Piracicaba, SP - Brazil
[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, 901 Limeira, 901 Ave, BR-13414018 Piracicaba, SP - Brazil
[3] Univ Sao Paulo, Food & Nutr Res Ctr NAPAN, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Food Chemistry; v. 281, p. 178-188, MAY 30 2019.
Citações Web of Science: 3
Resumo

Brazilian native fruits (BNF) remain unexplored and underutilized resources with a high potential to improve human health and wellness. In our study, five new BNF (Eugenia stipitata, Sageretia elegans, Byrsonima arthropoda, Spondias mombin and Rubus rosaefolius) were evaluated for their phenolic composition by LC-ESI-QTOF-MS; and for their ROS and RNS scavenging effects (ROO center dot, O-2(center dot-), NO center dot, HOCl); in vivo anti-inflammatory activity (neutrophil migration); and in vivo acute toxicity in Galleria mellonella. Eighty-six phenolic compounds were identified, including hydroxybenzoic acids, hydroxycinnamic acids, flavonoids, anthocyanins and ellagitannins, several of which had never been reported in BNF. The BNF exhibited high antioxidant effects against biologically relevant radicals, and treated animals showed decreased neutrophil influx and NF-kB activation. Thus, these BNF are good sources of antioxidant and anti-inflammatory molecules that can be beneficial for human health as functional foods. Based on their bioactivity, they can be considered as new Brazilian superfruits. (AU)

Processo FAPESP: 14/12606-3 - Frutas da Mata Atlântica potencialmente funcionais: caracterização, multiplicação de plantas e conservação pós-colheita
Beneficiário:Angelo Pedro Jacomino
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/13190-2 - Composição fenólica e potencial biológico, in vitro e in vivo, de frutíferas nativas do Brasil
Beneficiário:Severino Matias de Alencar
Linha de fomento: Auxílio à Pesquisa - Regular