Carotid chemoreflex activity restrains post-exercise cardiac autonomic control in healthy humans and in patients with pulmonary arterial hypertension

Autor(es):Mostrar menos -

Paula-Ribeiro, Marcelle ^{[1, 2, 3, 4]} ; Ribeiro, Indyanara C. ^{[1, 2, 3]} ; Aranda, Liliane C. ^{[1, 2, 3]} ; Silva, Talita M. ^{[1, 2, 3]} ; Costa, Camila M. ^{[2, 3]} ; Ramos, Roberta P. ^{[2, 3]} ; Ota-Arakaki, Jaquelina S. ^{[2, 3]} ; Cravo, Sergio L. ^[1] ; Nery, Luiz E. ^{[2, 3]} ; Stickland, Michael K. ^[5] ; Silva, Bruno M. ^{[1, 2, 3, 4]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Med, Div Resp Dis, Pulm Vasc Grp, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Med, Div Resp Dis, Pulm Funct & Clin Exercise Physiol Unit, Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Med, Postgrad Program Translat Med, Sao Paulo, SP - Brazil

^[5] Univ Alberta, Div Pulm Med, Edmonton, AB - Canada

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PHYSIOLOGY-LONDON; v. 597, n. 5, p. 1347-1360, MAR 1 2019.
• Citações Web of Science: 0

Resumo

Dysfunction of post-exercise cardiac autonomic control predicts mortality, but its underlying mechanisms remain unclear. We tested whether carotid chemoreflex activity restrains post-exercise cardiac autonomic control in healthy adults (HA), and whether such restraint is greater in patients with pulmonary arterial hypertension (PAH) who may have both altered carotid chemoreflex and altered post-exercise cardiac autonomic control. Twenty non-hypoxaemic patients with PAH and 13 age- and sex-matched HA pedalled until 90% of peak work rate observed in a symptom-limited ramp-incremental exercise test. Recovery consisted of unloaded pedalling for 5min followed by seated rest for 6min. During recovery, subjects randomly inhaled either 100% O-2 (hyperoxia) to inhibit the carotid chemoreceptor activity, or 21% O-2 (normoxia) as control. Post-exercise cardiac autonomic control was examined via heart rate (HR) recovery (HRR; HR change after 30, 60, 120 and 300s of recovery, using linear and non-linear regressions of HR decay) and HR variability (HRV; time and spectral domain analyses). As expected, the PAH group had higher carotid chemosensitivity and worse post-exercise HRR and HRV than HA. Hyperoxia increased HRR at 30, 60 and 120s and absolute spectral power HRV in both groups. Additionally, hyperoxia resulted in an accelerated linear HR decay and increased time domain HRV during active recovery only in the PAH group. In conclusion, the carotid chemoreceptors restrained recovery of cardiac autonomic control from exercise in HA and in patients with PAH, with the restraint greater for some autonomic indexes in patients with PAH. (AU)

• Processo FAPESP: 15/22198-2 - Contribuição tônica do quimiorreflexo periférico para o controle vagal do coração em repouso, ortostatismo e na recuperação do exercício em pacientes com hipertensão arterial pulmonar
• Beneficiário: Marcelle de Paula Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/23622-5 - Contribuição do quimiorreflexo periférico para o controle vagal do coração na recuperação do exercício em indivíduos saudáveis
• Beneficiário: Indyanara Cristina Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/24294-6 - Contribuição tônica do quimiorreflexo periférico no controle vagal do coração em repouso e na recuperação do exercício em pacientes com insuficiência cardíaca crônica
• Beneficiário: Bruno Moreira Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/01155-6 - Respostas cardiorrespiratórias decorrentes da interação entre o quimiorreflexo periférico e o mecanorreflexo muscular em indivíduos saudáveis
• Beneficiário: Talita Miranda Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado