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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia

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Autor(es):
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Dal Mas, Caroline [1] ; Nani, Joao V. [1] ; Noto, Cristiano [2, 3] ; Yonamine, Camila M. [1] ; da Cunha, Graccielle Rodrigues [3] ; Mansur, Rodrigo B. [4] ; Ota, Vanessa K. [5] ; Belangero, Sintia Iole [5] ; Cordeiro, Quirino [6] ; Kapczinski, Flavio [7] ; Brietzke, Elisa [3] ; Bressan, Rodrigo A. [3] ; Gadelha, Ary [3] ; Hayashi, Mirian A. F. [1]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, EPM, Dept Pharmacol, Rua 3 Maio 100, Ed INFAR, 3rd Floor, BR-04044020 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, PRISMA Program Recognit & Intervent Subjects At R, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, EPM, Dept Psychiat, Sao Paulo - Brazil
[4] Univ Hlth Network, Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON - Canada
[5] Univ Fed Sao Paulo UNIFESP, EPM, Dept Morphol & Genet, Sao Paulo - Brazil
[6] ISCMSP, Sao Paulo - Brazil
[7] McMaster Univ, Hamilton, ON - Canada
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: SCHIZOPHRENIA RESEARCH; v. 208, p. 202-208, JUN 2019.
Citações Web of Science: 2
Resumo

Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naive first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naive FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months ( FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y). and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. (C) 2019 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 11/50740-5 - Prevenção na esquizofrenia e no transtorno bipolar da neurociência à comunidade: uma plataforma multifásica, multimodal e translacional para investigação e intervenção
Beneficiário:Rodrigo Affonseca Bressan
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/13392-4 - Avaliação do uso dos análogos da crotamina em diagnóstico ou terapia
Beneficiário:Mirian Akemi Furuie Hayashi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/08941-6 - Estudo das oligopeptidases na esquizofrenia
Beneficiário:Camila Miyagui Yonamine Asanuma
Linha de fomento: Bolsas no Brasil - Pós-Doutorado