Angiotensin II type 2 receptor mediates high fat diet-induced cardiomyocyte hypertrophy and hypercholesterolemia

Autor(es)

Lima, Vanessa M. ^[1] ; Lino, Caroline A. ^[1] ; Senger, Nathalia ^[1] ; Silva, Tabatha de Oliveira ^[1] ; Fonseca, Renata I. B. ^[1] ; Bader, Michael ^[2] ; Santos, Robson A. S. ^[3] ; Donato Junior, Jose ^[4] ; Barreto-Chaves, Maria Luiza M. ^[1] ; Diniz, Gabriela P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil

^[2] Max Delbruck Ctr Mol Med, Berlin - Germany

^[3] Univ Fed Minas Gerais, Dept Physiol & Biophys, Belo Horizonte, MG - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Endocrinology; v. 498, DEC 1 2019.
• Citações Web of Science: 0

Resumo

Obesity is the major risk factor for several cardiovascular and metabolic disorders. Previous studies reported that deletion of Angiotensin II type 2 receptor (AT2R) protects against metabolic dysfunctions induced by high fat (HF) diet. However, the role of AT2R in obesity-induced cardiac hypertrophy remains unclear. Male AT2R knockout (AT2RKO) and wild type (AT2RWT) mice were fed with control or HF diet for 10 weeks. HF diet increased cardiac expression of AT2R in obese mice. Deletion of AT2R did not affect body weight gain, glucose intolerance and fat mass gain induced by HF feeding. However, loss of AT2R prevented HF diet-induced hypercholesterolemia and cardiac remodeling. Mechanistically, we found that pharmacological inhibition or knockdown of AT2R prevented leptin-induced cardiomyocyte hypertrophy in vitro. Collectively, our results suggest that AT2R is involved in obesity-induced cardiac hypertrophy. (AU)

• Processo FAPESP: 15/21859-5 - Papel do microRNA-22 na instalação das alterações cardíacas e metabólicas induzidas pela dieta rica em gordura
• Beneficiário: Gabriela Placoná Diniz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/10338-2 - Impacto do microRNA-22 na diferenciação de adipócitos marrons e no processo de browning do tecido adiposo branco
• Beneficiário: Gabriela Placoná Diniz
• Modalidade de apoio: Auxílio à Pesquisa - Regular