| Full text | |
| Author(s): |
Lima, Vanessa M.
[1]
;
Lino, Caroline A.
[1]
;
Senger, Nathalia
[1]
;
Silva, Tabatha de Oliveira
[1]
;
Fonseca, Renata I. B.
[1]
;
Bader, Michael
[2]
;
Santos, Robson A. S.
[3]
;
Donato Junior, Jose
[4]
;
Barreto-Chaves, Maria Luiza M.
[1]
;
Diniz, Gabriela P.
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
[2] Max Delbruck Ctr Mol Med, Berlin - Germany
[3] Univ Fed Minas Gerais, Dept Physiol & Biophys, Belo Horizonte, MG - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Molecular and Cellular Endocrinology; v. 498, DEC 1 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Obesity is the major risk factor for several cardiovascular and metabolic disorders. Previous studies reported that deletion of Angiotensin II type 2 receptor (AT2R) protects against metabolic dysfunctions induced by high fat (HF) diet. However, the role of AT2R in obesity-induced cardiac hypertrophy remains unclear. Male AT2R knockout (AT2RKO) and wild type (AT2RWT) mice were fed with control or HF diet for 10 weeks. HF diet increased cardiac expression of AT2R in obese mice. Deletion of AT2R did not affect body weight gain, glucose intolerance and fat mass gain induced by HF feeding. However, loss of AT2R prevented HF diet-induced hypercholesterolemia and cardiac remodeling. Mechanistically, we found that pharmacological inhibition or knockdown of AT2R prevented leptin-induced cardiomyocyte hypertrophy in vitro. Collectively, our results suggest that AT2R is involved in obesity-induced cardiac hypertrophy. (AU) | |
| FAPESP's process: | 15/21859-5 - Role of microRNA-22 in the development of cardiac and metabolic alterations induced by high fat diet |
| Grantee: | Gabriela Placoná Diniz |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/10338-2 - Role of microRNA-22 in differentiation of brown adipocytes and in browning of white adipose tissue |
| Grantee: | Gabriela Placoná Diniz |
| Support Opportunities: | Regular Research Grants |