Orally disintegrating films based on gelatin and pregelatinized starch: new carriers of active compounds from acerola

Autor(es)

dos Santos Garcia, Vitor Augusto ^[1] ; Borges, Josiane Goncalves ^[1] ; Osiro, Denise ^[2] ; Vanin, Fernanda Maria ^[1] ; de Carvalho, Rosemary Aparecida ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Av Duque Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil

^[2] Univ Ctr Guaxupe Educ Fdn, Av Dona Floriana 463, BR-37800000 Guaxupe, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FOOD HYDROCOLLOIDS; v. 101, APR 2020.
• Citações Web of Science: 8

Resumo

This study aimed to produce orally disintegrating films (ODFs) based on pregelatinized starch and gelatin with the incorporation of acerola powder and to evaluate the effect of the macromolecule concentration on the properties of the films. No ODFs had insoluble particles, and microstructure analysis by atomic force microscopy showed that higher starch concentrations led to greater surface heterogeneity and roughness. Starch inclusion in the films enhanced the hydrophilicity of the material (producing lower contact angle values). These factors, along with higher levels of starch, probably contributed to the favorable disintegration time, as observed by the lower values from in vitro and in vivo analyses. The FTIR spectra of the ODFs demonstrate predominant presence of carbohydrates and proteins, showing good interaction between them. In addition, the antioxidant capacity results showed that, after 50 days of storage under drastic conditions (75% relative humidity and 40 degrees C), the ODFs retained at least 60% of their antioxidant capacity. Therefore, the ODF containing acerola powder represents a promising system for use in active compound delivery. (AU)

• Processo FAPESP: 13/03143-7 - Desenvolvimento de matrizes poliméricas como veículos de ácido ascórbico: caracterização e avaliação da estabilidade
• Beneficiário: Vitor Augusto dos Santos Garcia
• Modalidade de apoio: Bolsas no Brasil - Doutorado