Orally disintegrating films based on gelatin and pregelatinized starch: new carriers of active compounds from acerola

Author(s)

dos Santos Garcia, Vitor Augusto ^[1] ; Borges, Josiane Goncalves ^[1] ; Osiro, Denise ^[2] ; Vanin, Fernanda Maria ^[1] ; de Carvalho, Rosemary Aparecida ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Av Duque Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil

^[2] Univ Ctr Guaxupe Educ Fdn, Av Dona Floriana 463, BR-37800000 Guaxupe, MG - Brazil

• Document type: Journal article
• Source: FOOD HYDROCOLLOIDS; v. 101, APR 2020.
• Web of Science Citations: 8

Abstract

This study aimed to produce orally disintegrating films (ODFs) based on pregelatinized starch and gelatin with the incorporation of acerola powder and to evaluate the effect of the macromolecule concentration on the properties of the films. No ODFs had insoluble particles, and microstructure analysis by atomic force microscopy showed that higher starch concentrations led to greater surface heterogeneity and roughness. Starch inclusion in the films enhanced the hydrophilicity of the material (producing lower contact angle values). These factors, along with higher levels of starch, probably contributed to the favorable disintegration time, as observed by the lower values from in vitro and in vivo analyses. The FTIR spectra of the ODFs demonstrate predominant presence of carbohydrates and proteins, showing good interaction between them. In addition, the antioxidant capacity results showed that, after 50 days of storage under drastic conditions (75% relative humidity and 40 degrees C), the ODFs retained at least 60% of their antioxidant capacity. Therefore, the ODF containing acerola powder represents a promising system for use in active compound delivery. (AU)

• FAPESP's process: 13/03143-7 - Development of polymer matrices as carriers of ascorbic acid: characterization and evaluation of stability
• Grantee: Vitor Augusto dos Santos Garcia
• Support Opportunities: Scholarships in Brazil - Doctorate