Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers?

Autor(es)

Buzalaf, Marilia Afonso Rabelo ^[1] ; Ortiz, Adriana de Cassia ^[1] ; Carvalho, Thamyris Souza ^[1] ; Fideles, Simone Ortiz Moura ^[1] ; Araujo, Tamara Teodoro ^[1] ; Moraes, Samanta Mascarenhas ^[1] ; Buzalaf, Nathalia Rabelo ^[1] ; Reis, Fernanda Navas ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Bauru, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS; v. 20, n. 5 MAR 2020.
• Citações Web of Science: 0

Resumo

Introduction: A biomarker is a biological indicator of normal or pathogenic processes. Identification of biomarkers is useful for the prevention, diagnosis and prognosis of diseases as well as for monitoring the progression of pathological disorders. Several types of molecules present in biological fluids can act as biomarkers such as DNA, coding and non-coding RNA, lipids, metabolites, proteins and even microbes. In this context, saliva emerges as a useful diagnostic tool for the detection of biomarkers involved with oral and systemic diseases, since it reflects the pathophysiological conditions of the organism and allows early, rapid, practical and noninvasive detection of biomarkers. Areas covered: This review discusses the properties of saliva as a diagnostic tool and addresses the main identified biomarkers related to dental caries, periodontal disease, head and neck cancer and other types of cancer of considerable incidence among the world population. Expert commentary: Despite extensive efforts which have been directed toward the identification of one or a combination of biomarkers with good predictive values for the early detection of dental caries, periodontal disease and cancer, these biomarkers still need validation before chairside point-of-care devices can be widely used in the clinic. (AU)

• Processo FAPESP: 18/18147-1 - Prevenção e remineralização de lesões de mancha branca em ortodontia: comparação da eficácia do verniz de fluoreto de sódio e do verniz de tetrafluoreto de titânio (TiF4)
• Beneficiário: Samanta Mascarenhas Moraes
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
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• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/18240-1 - Novo biomaterial composto por celulose bacteriana produzida por Gluconacetobacer xylinus e nanopartícula de prata
• Beneficiário: Fernanda Navas Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica