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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers?

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Author(s):
Buzalaf, Marilia Afonso Rabelo [1] ; Ortiz, Adriana de Cassia [1] ; Carvalho, Thamyris Souza [1] ; Fideles, Simone Ortiz Moura [1] ; Araujo, Tamara Teodoro [1] ; Moraes, Samanta Mascarenhas [1] ; Buzalaf, Nathalia Rabelo [1] ; Reis, Fernanda Navas [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Bauru, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS; v. 20, n. 5 MAR 2020.
Web of Science Citations: 0
Abstract

Introduction: A biomarker is a biological indicator of normal or pathogenic processes. Identification of biomarkers is useful for the prevention, diagnosis and prognosis of diseases as well as for monitoring the progression of pathological disorders. Several types of molecules present in biological fluids can act as biomarkers such as DNA, coding and non-coding RNA, lipids, metabolites, proteins and even microbes. In this context, saliva emerges as a useful diagnostic tool for the detection of biomarkers involved with oral and systemic diseases, since it reflects the pathophysiological conditions of the organism and allows early, rapid, practical and noninvasive detection of biomarkers. Areas covered: This review discusses the properties of saliva as a diagnostic tool and addresses the main identified biomarkers related to dental caries, periodontal disease, head and neck cancer and other types of cancer of considerable incidence among the world population. Expert commentary: Despite extensive efforts which have been directed toward the identification of one or a combination of biomarkers with good predictive values for the early detection of dental caries, periodontal disease and cancer, these biomarkers still need validation before chairside point-of-care devices can be widely used in the clinic. (AU)

FAPESP's process: 18/18147-1 - Prevention and remineralization of white spot lesions in orthodontics: comparison of sodium fluoride varnish and titanium tetrafluoride varnish (TiF4)
Grantee:Samanta Mascarenhas Moraes
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/08032-5 - Acquired pellicle engineering for protection against caries and tooth erosion: effect of cystatin, statherin and hemoglobin on the proteomic profile of the acquired pellicle, bacterial biofilm and dental enamel
Grantee:Tamara Teodoro Araujo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/18240-1 - New biomaterial composed by bacterial cellulose produced by Gluconacetobacer xylinus and silver nanoparticle
Grantee:Fernanda Navas Reis
Support Opportunities: Scholarships in Brazil - Scientific Initiation