New biomaterial composed by bacterial cellulose produced by Gluconacetobacer xylinus and silver nanoparticle

• Grant number: 18/18240-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2018
• Effective date (End): October 31, 2019
• Field of knowledge: Biological Sciences - Biophysics - Biophysics of Processes and Systems
• Principal Investigator: Angela Mitie Otta Kinoshita
• Grantee: Fernanda Navas Reis
• Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil

Abstract

A biomaterial that has been studied to compose biomaterials is bacterial cellulose (CB). CB is obtained mainly from cultures of Gram-negative bacteria such as Acetobacter xylinum (Gluconacetobacter xylinus). It presents high modulus of elasticity and tension, besides the high crystallinity due to the nanofibres in a three-dimensional network, present in its structure. The degradation time of the biomaterial in the organism where it has been implanted must be compatible with its function, that is, it can not occur advanced degradation or that the material stays in the body for a long time even after the complete regeneration of the tissue. In the case of CB, the degradation time is quite long, so the reduction of this is of great importance for some applications. Thus, in this project, irradiation of CB with gamma radiation, in different doses, will be used as a method to obtain a faster degradation of this. In addition, silver nanoparticles (AgNP) will be impregnated in the biomaterial, with the aim of adding antimicrobial activity to it, as well as optimizing the effect of ionizing radiation, by increasing the shock section, forming a new biomaterial with antimicrobial property and shorter time of degradation.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUZALAF, MARILIA AFONSO RABELO; ORTIZ, ADRIANA DE CASSIA; CARVALHO, THAMYRIS SOUZA; FIDELES, SIMONE ORTIZ MOURA; ARAUJO, TAMARA TEODORO; MORAES, SAMANTA MASCARENHAS; BUZALAF, NATHALIA RABELO; REIS, FERNANDA NAVAS. Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers?. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, v. 20, n. 5, MAR 2020. (18/18147-1, 19/08032-5, 18/18240-1)