|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||November 01, 2018|
|Effective date (End):||October 31, 2019|
|Field of knowledge:||Biological Sciences - Biophysics - Biophysics of Processes and Systems|
|Principal researcher:||Angela Mitie Otta Kinoshita|
|Grantee:||Fernanda Navas Reis|
|Home Institution:||Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil|
A biomaterial that has been studied to compose biomaterials is bacterial cellulose (CB). CB is obtained mainly from cultures of Gram-negative bacteria such as Acetobacter xylinum (Gluconacetobacter xylinus). It presents high modulus of elasticity and tension, besides the high crystallinity due to the nanofibres in a three-dimensional network, present in its structure. The degradation time of the biomaterial in the organism where it has been implanted must be compatible with its function, that is, it can not occur advanced degradation or that the material stays in the body for a long time even after the complete regeneration of the tissue. In the case of CB, the degradation time is quite long, so the reduction of this is of great importance for some applications. Thus, in this project, irradiation of CB with gamma radiation, in different doses, will be used as a method to obtain a faster degradation of this. In addition, silver nanoparticles (AgNP) will be impregnated in the biomaterial, with the aim of adding antimicrobial activity to it, as well as optimizing the effect of ionizing radiation, by increasing the shock section, forming a new biomaterial with antimicrobial property and shorter time of degradation.