The role of neutrophils in neuro-immune modulation

Autor(es):Mostrar menos -

Kanashiro, Alexandre ^{[1, 2]} ; Hiroki, Carlos Hiroji ^[3] ; da Fonseca, Denise Morais ^[4] ; Birbrair, Alexander ^[5] ; Ferreira, Raphael Gomes ^[6] ; Bassi, Gabriel Shimizu ^[7] ; Fonseca, Mirian D. ^[1] ; Kusuda, Ricardo ^[1] ; Martelossi Cebinelli, Guilherme Cesar ^[3] ; da Silva, Katiussia Pinho ^[8] ; Wanderley, Carlos Wagner ^[1] ; Menezes, Gustavo Batista ^[9] ; Alves-Fiho, Jose Carlos ^[1] ; Oliveira, Andre Gustavo ^[10] ; Cunha, Thiago M. ^[1] ; Pupo, Andre Sampaio ^[8] ; Ulloa, Luis ^[7] ; Cunha, Fernando Queiroz ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Immunol & Biochem, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, SP - Brazil

^[5] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG - Brazil

^[6] Fed Univ Tocantins, Araguaina Med Sch, Ave Paraguai S-N, BR-77824838 Araguaina, TO - Brazil

^[7] Duke Univ, Dept Anesthesiol, Ctr Perioperat Organ Protect, Durham, NC 27710 - USA

^[8] Univ Estadual Paulista, Inst Biociencias, Dept Pharmacol, Botucatu, SP - Brazil

^[9] Univ Fed Minas Gerais, Dept Morphol, Belo Horizonte, MG - Brazil

^[10] Univ Fed Minas Gerais, Dept Physiol & Biophys, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PHARMACOLOGICAL RESEARCH; v. 151, JAN 2020.
• Citações Web of Science: 1

Resumo

Neutrophils are peripheral immune cells that represent the first recruited innate immune defense against infections and tissue injury. However, these cells can also induce overzealous responses and cause tissue damage. Although the role of neutrophils activating the immune system is well established, only recently their critical implications in neuro-immune interactions are becoming more relevant. Here, we review several aspects of neutrophils in the bidirectional regulation between the nervous and immune systems. First, the role of neutrophils as a diffuse source of acetylcholine and catecholamines is controversial as well as the effects of these neurotransmitters in neutrophil's functions. Second, neutrophils contribute for the activation and sensitization of sensory neurons, and thereby, in events of nociception and pain. In addition, nociceptor activation promotes an axon reflex triggering a local release of neural mediators and provoking neutrophil activation. Third, the recruitment of neutrophils in inflammatory responses in the nervous system suggests these immune cells as innovative targets in the treatment of central infectious, neurological and neurodegenerative disorders. Multidisciplinary studies involving immunologists and neuroscientists are required to define the role of the neurons-neutrophils communication in the pathophysiology of infectious, inflammatory, and neurological disorders. (AU)

• Processo FAPESP: 16/08385-7 - Cicatriz imunológica pós-infecção intestinal aguda e desenvolvimento de desordens metabólicas: estudo das interações entre a microbiota e sistema imunológico do mesentério
• Beneficiário: Denise Morais da Fonseca
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias
• Beneficiário: Fernando de Queiroz Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 11/20343-4 - Via colinérgica anti-inflamatória: o papel da neuroimunomodulação no controle da resposta inflamatória
• Beneficiário: Alexandre Kanashiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 11/19670-0 - Mecanismos envolvidos na fisiopatologia da artrite reumatóide, dor e sepse
• Beneficiário: Fernando de Queiroz Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/04237-2 - Via Colinérgica Anti-inflamatória: O papel da neuroimunomodulação no controle da resposta Inflamatória.
• Beneficiário: Alexandre Kanashiro
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores