The role of neutrophils in neuro-immune modulation

Author(s):Show less -

Kanashiro, Alexandre ^{[1, 2]} ; Hiroki, Carlos Hiroji ^[3] ; da Fonseca, Denise Morais ^[4] ; Birbrair, Alexander ^[5] ; Ferreira, Raphael Gomes ^[6] ; Bassi, Gabriel Shimizu ^[7] ; Fonseca, Mirian D. ^[1] ; Kusuda, Ricardo ^[1] ; Martelossi Cebinelli, Guilherme Cesar ^[3] ; da Silva, Katiussia Pinho ^[8] ; Wanderley, Carlos Wagner ^[1] ; Menezes, Gustavo Batista ^[9] ; Alves-Fiho, Jose Carlos ^[1] ; Oliveira, Andre Gustavo ^[10] ; Cunha, Thiago M. ^[1] ; Pupo, Andre Sampaio ^[8] ; Ulloa, Luis ^[7] ; Cunha, Fernando Queiroz ^[1]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Immunol & Biochem, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, SP - Brazil

^[5] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG - Brazil

^[6] Fed Univ Tocantins, Araguaina Med Sch, Ave Paraguai S-N, BR-77824838 Araguaina, TO - Brazil

^[7] Duke Univ, Dept Anesthesiol, Ctr Perioperat Organ Protect, Durham, NC 27710 - USA

^[8] Univ Estadual Paulista, Inst Biociencias, Dept Pharmacol, Botucatu, SP - Brazil

^[9] Univ Fed Minas Gerais, Dept Morphol, Belo Horizonte, MG - Brazil

^[10] Univ Fed Minas Gerais, Dept Physiol & Biophys, Belo Horizonte, MG - Brazil

• Document type: Review article
• Source: PHARMACOLOGICAL RESEARCH; v. 151, JAN 2020.
• Web of Science Citations: 1

Abstract

Neutrophils are peripheral immune cells that represent the first recruited innate immune defense against infections and tissue injury. However, these cells can also induce overzealous responses and cause tissue damage. Although the role of neutrophils activating the immune system is well established, only recently their critical implications in neuro-immune interactions are becoming more relevant. Here, we review several aspects of neutrophils in the bidirectional regulation between the nervous and immune systems. First, the role of neutrophils as a diffuse source of acetylcholine and catecholamines is controversial as well as the effects of these neurotransmitters in neutrophil's functions. Second, neutrophils contribute for the activation and sensitization of sensory neurons, and thereby, in events of nociception and pain. In addition, nociceptor activation promotes an axon reflex triggering a local release of neural mediators and provoking neutrophil activation. Third, the recruitment of neutrophils in inflammatory responses in the nervous system suggests these immune cells as innovative targets in the treatment of central infectious, neurological and neurodegenerative disorders. Multidisciplinary studies involving immunologists and neuroscientists are required to define the role of the neurons-neutrophils communication in the pathophysiology of infectious, inflammatory, and neurological disorders. (AU)

• FAPESP's process: 16/08385-7 - Impact of infection-induced immunological scarring on the long-term host metabolic homeostasis
• Grantee: Denise Morais da Fonseca
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
• Grantee: Fernando de Queiroz Cunha
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 11/20343-4 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response
• Grantee: Alexandre Kanashiro
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 11/19670-0 - Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis
• Grantee: Fernando de Queiroz Cunha
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 12/04237-2 - Antiinflammatory Cholinergic Pathway: The role of neuroimmunomodulation in the control of inflammatory response.
• Grantee: Alexandre Kanashiro
• Support Opportunities: Scholarships in Brazil - Young Researchers