Advanced search
Start date
Betweenand

Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis

Grant number: 11/19670-0
Support type:Research Projects - Thematic Grants
Duration: May 01, 2012 - June 30, 2017
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Fernando de Queiroz Cunha
Grantee:Fernando de Queiroz Cunha
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:José Carlos Farias Alves Filho ; Paulo Louzada Junior ; Sérgio Henrique Ferreira ; Thiago Mattar Cunha
Associated grant(s):13/09434-3 - Immunopharmacological salivary modulators from hematophagous arthropods, AV.EXT
Associated scholarship(s):15/22182-9 - The role of the transient receptor potencial vanilloid-1 in the induction and maintenance of herpetic- and Post-Herpetic Neuralgia, BP.IC
14/09008-7 - The role of pattern recognition receptors like toll-like receptors 4 in the induction and maintenance of herpetic and Post-Herpetic Neuralgia, BP.PD
13/15316-3 - Investigation of the protective role of interleukin 27 (IL-27) on the genesis and maintenance of neuropathic pain, BP.DR
+ associated scholarships 13/04942-0 - Molecular mechanisms involved in the enhancement of Th17 response by aryl hydrocarbon receptor (AhR) - correlation with rheumatoid arthritis, BP.DR
13/07968-0 - The role of indoleamine 2,3-dioxygenase in supraspinal structures in the induction and maintenance of neuropathic pain, BP.MS
13/03758-1 - Role of D6 receptor in development and maintenance of chronic neuropathic pain, BP.DR
12/04132-6 - Role of D6 receptor in the inflammatory response development during sepsis, BP.DR
12/04076-9 - Role of the aryl hydrocarbon receptor (AhR) in the pathogenesis of sepsis, BP.PD
11/13097-7 - Role of indoleamine 2,3-dioxygenase in the induction and maintenance of neuropathic pain, BP.PD - associated scholarships

Abstract

For the past 25 years, our group has been studying the physiopathological mechanisms involved in the inflammatory process. In order to continue doing so, in this project we seek to do translational research regarding inflammatory diseases, mainly rheumatoid arthritis, chronic pain and sepsis. All three topics will be investigated in an integrated stand: 1) mechanisms involved in recognizing the triggering agents, focusing in pattern recognition receptors (TLRs and NLRs), their endogenous ligands and the activation of recognition cells (dendritic cells, glial cell, mastocytes, synoviocytes); 2) effector mechanisms, especially regarding cytokines and chemokines roles and their receptors, and effector cells (neutrophils, lymphocytes and macrophages); intracellular signaling, including intracellular receptors (AhR, PPARgama, LXR) and transcription factors (NFkB, AP-1, CREB); and finally 4) immune response modulators, focusing in adenosine, Indoleamine 2,3-dioxygenase, eicosanoids and co-stimulatory molecule CD28. Developing this project will allow the identification of new common biological target to most of the three aforementioned topics, leading to the development of new biological markers and treatment schemes for those diseases. (AU)

Scientific publications (62)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUIMARAESI, RAFAELA M.; DAVOLI-FERREIRA, MARCELA; FONSECA, MIRIAM M.; DAMASCENO, LUIS EDUARDO A.; SANTA-CECILIA, V, FLAVIA; KUSUDA, RICARDO; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M. Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury. Journal of Leukocyte Biology, v. 106, n. 3, SI, p. 541-551, SEP 2019. Web of Science Citations: 0.
MEDEIROS, PRISCILA; NEGRINI-FERRARI, SYLMARA ESTHER; PALAZZO, ENZA; MAIONE, SABATINO; FERREIRA, SERGIO HENRIQUE; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain. Neurochemical Research, v. 44, n. 9, p. 2068-2080, SEP 2019. Web of Science Citations: 1.
PINTO, LARISSA G.; SOUZA, GUILHERME R.; KUSUDA, RICARDO; LOPES, ALEXANDRE H.; SANT'ANNA, MORENA B.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; CUNHA, THIAGO M. Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice. Molecular Neurobiology, v. 56, n. 8, p. 5715-5728, AUG 2019. Web of Science Citations: 0.
COLON, DAVID F.; WANDERLEY, CARLOS W.; FRANCHIN, MARCELO; SILVA, CAMILA M.; HIROKI, CARLOS H.; CASTANHEIRA, FERNANDA V. S.; DONATE, PAULA B.; LOPES, ALEXANDRE H.; VOLPON, LEILA C.; KAVAGUTI, SILVIA K.; BORGES, VANESSA F.; SPECK-HERNANDEZ, CESAR A.; RAMALHO, FERNANDO; CARLOTTI, ANA P.; CARMONA, FABIO; ALVES-FILHO, JOSE C.; LIEW, FOO Y.; CUNHA, FERNANDO Q. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. CRITICAL CARE, v. 23, APR 8 2019. Web of Science Citations: 0.
SANTA-CECILIA, V, FLAVIA; FERREIRA, DAVID W.; GUIMARAES, RAFAELA M.; CECILIO, NERRY T.; FONSECA, MIRIAM M.; LOPES, ALEXANDRE H.; DAVOLI-FERREIRA, MARCELA; KUSUDA, RICARDO; SOUZA, GUILHERME R.; NACHBUR, UELI; ALVES-FILHO, JOSE C.; TEIXEIRA, MAURO M.; ZAMBONI, DARIO S.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M. The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development. Pain, v. 160, n. 1, p. 102-116, JAN 2019. Web of Science Citations: 1.
LOURENCO-GONZALEZ, YURI; FATTORI, VICTOR; DOMICIANO, TALITA P.; ROSSANEIS, ANA C.; BORGHI, SERGIO M.; ZANINELLI, TIAGO H.; BERNARDY, CATIA C. F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI JR, WALDICEU A. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation, 2019. Web of Science Citations: 0.
MANCHOPE, MARILIA F.; ARTERO, NAYARA A.; FATTORI, VICTOR; MIZOKAMI, SANDRA S.; PITOL, DIMITRIUS L.; ISSA, JOAO P. M.; FUKADA, SANDRA Y.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NF kappa B. Inflammation Research, v. 67, n. 11-12, p. 997-1012, DEC 2018. Web of Science Citations: 2.
SARAIVA, ANDRE L.; VERAS, FLAVIO P.; PERES, RAPHAEL S.; TALBOT, JHIMMY; DE LIMA, KALIL A.; LUIZ, JOAO P.; CARBALLIDO, JOSE M.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; RYFFEL, BERNHARD; ALVES-FILHO, JOSE C. Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of T(h)17 cells in the lymph nodes. FASEB JOURNAL, v. 32, n. 12, p. 6550-6558, DEC 2018. Web of Science Citations: 4.
FERREIRA, RAPHAEL G.; RODRIGUES, LILIAN C.; NASCIMENTO, DANIELE C.; KANASHIRO, ALEXANDRE; MELO, PAULO H.; BORGES, VANESSA F.; GOZZI, ALINE; PRADO, DOUGLAS DA SILVA; BORGES, MARCOS C.; RAMALHO, FERNANDO S.; STOWELL, SEAN R.; CUMMINGS, RICHARD D.; DIAS-BARUFFI, MARCELO; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C. Galectin-3 aggravates experimental polymicrobial sepsis by impairing neutrophil recruitment to the infectious focus. Journal of Infection, v. 77, n. 5, p. 391-397, NOV 2018. Web of Science Citations: 2.
STAURENGO-FERRARI, LARISSA; RUIZ-MIYAZAWA, KENJI W.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; CARVALHO, THACYANA T.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI JR, WALDICEU A. Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, OCT 2 2018. Web of Science Citations: 3.
FATTORI, VICTOR; ZARPELON, ANA C.; STAURENGO-FERRARI, LARISSA; BORGHI, SERGIO M.; ZANINELII, TIAGO H.; DA COSTA, FERNANDO B.; AIVES, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; ARAKAWA, NILTON S.; VERN JR, WALDICEU A. Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model o Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, SEP 25 2018. Web of Science Citations: 2.
RUIZ-MIYAZAWA, KENJI W.; STAURENGO-FERRARI, LARISSA; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; ANDRADE, KETLEM C.; CLEMENTE-NAPIMOGA, JULIANA T.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; FRACETO, LEONARDO F.; CUNHA, FERNANDO Q.; NAPIMOGA, MARCELO H.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. 15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice. SCIENTIFIC REPORTS, v. 8, SEP 18 2018. Web of Science Citations: 5.
RUIZ-MIYAZAWA, KENJI W.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; STAURENGO-FERRARI, LARISSA; FATTORI, VICTOR; FERNANDES, GLAURA S. A.; CASELLA, ANTONIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF kappa B and macrophage release of IL-1 beta. Journal of Functional Foods, v. 48, p. 106-116, SEP 2018. Web of Science Citations: 0.
TALBOT, JHIMMY; PERES, RAPHAEL S.; PINTO, LARISSA G.; OLIVEIRA, RENE D. R.; LIMA, KALIL A.; DONATE, PAULA B.; SILVA, JAQUELINE R.; RYFFEL, BERNARD; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; LIEW, FOO Y.; LOUZADA-JUNIOR, PAULO; CUNHA, FERNANDO DE QUEIROZ. Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells. ARTHRITIS RESEARCH & THERAPY, v. 20, JUN 8 2018. Web of Science Citations: 7.
SILVA CASTANHEIRA, FERNANDA V. E; BORGES, VANESSA; SONEGO, FABIANE; KANASHIRO, ALEXANDRE; DONATE, PAULA B.; MELO, PAULO H.; PALLAS, KENNETH; RUSSO, REMO C.; AMARAL, FLAVIO A.; TEIXEIRA, MAURO M.; RAMALHO, FERNANDO S.; CUNHA, THIAGO M.; LIEW, FOO Y.; ALVES-FILHO, JOSE C.; GRAHAM, GERARD J.; CUNHA, FERNANDO Q. THE ATYPICAL CHEMOKINE RECEPTOR ACKR2 IS PROTECTIVE AGAINST SEPSIS. Shock, v. 49, n. 6, p. 682-689, JUN 2018. Web of Science Citations: 3.
STAURENGO-FERRARI, LARISSA; TREVELIN, SILVIA C.; FATTORI, VICTOR; NASCIMENTO, DANIELE C.; DE LIMA, KALIL A.; PELAYO, JACINTA S.; FIGUEIREDO, FLORENCIO; CASAGRANDE, RUBIA; FUKADA, SANDRA Y.; TEIXEIRA, MAURO M.; CUNHA, THIAGO M.; LIEW, FOO Y.; OLIVEIRA, RENE D.; LOUZADA-JUNIOR, PAULO; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; VERRI, WALDICEU A. Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-lnduced Septic Arthritis. FRONTIERS IN IMMUNOLOGY, v. 9, MAY 16 2018. Web of Science Citations: 3.
SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; DELA CRUZ, CHARLES S.; ANDREWS, NATHANIEL; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.; SEREZANI, C. HENRIQUE. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. Science Signaling, v. 11, n. 528 MAY 1 2018. Web of Science Citations: 1.
SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; HORTA, CATARINA V.; KANASHIRO, ALEXANDRE; CZAIKOSKI, PAULA G.; ZAMBONI, DARIO S.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q. The host control of a clinical isolate strain of P-aeruginosa infection is independent of Nod-1 but depends on MyD88. Inflammation Research, v. 67, n. 5, p. 435-443, MAY 2018. Web of Science Citations: 0.
ZARPELON, ANA C.; FATTORI, VICTOR; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PINHO-RIBEIRO, FELIPE A.; RUIZ-MIYAZAWA, KENJI W.; TURATO, WALTER M.; CUNHA, THIAGO M.; DA COSTA, FERNANDO B.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; ARAKAWA, NILTON S.; VERRI, JR., WALDICEU A. The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-kappa B and Cytokines. Inflammation, v. 40, n. 6, p. 2020-2032, DEC 2017. Web of Science Citations: 6.
BERTOZZI, MARIANA M.; ROSSANEIS, ANA C.; FATTORI, VICTOR; LONGHI-BALBINOT, DANIELA T.; FREITAS, ANDRESSA; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. Chemico-Biological Interactions, v. 273, p. 180-189, AUG 1 2017. Web of Science Citations: 8.
PINEROS ALVAREZ, ANNIE ROCIO; GLOSSON-BYERS, NICOLE; BRANDT, STEPHANIE; WANG, SOUJUAN; WONG, HECTOR; STURGEON, SARAH; MCCARTHY, BRIAN PAUL; TERRITO, PAUL R.; ALVES-FILHO, JOSE CARLOS; HENRIQUE SEREZANI, C. SOCS1 is a negative regulator of metabolic reprogramming during sepsis. JCI INSIGHT, v. 2, n. 13 JUL 6 2017. Web of Science Citations: 7.
SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; TALBOT, JHIMMY; CECILIO, NERRY T.; ROSSATO, MATEUS F.; SILVA, RANGEL L.; SOUZA, GUILHERME R.; SILVA, CASSIA R.; LUCAS, GUILHERME; FONSECA, BENEDITO A.; ARRUDA, EURICO; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. JOURNAL OF NEUROSCIENCE, v. 37, n. 27, p. 6408-6422, JUL 5 2017. Web of Science Citations: 2.
ZUCOLOTO, AMANDA Z.; MANCHOPE, MARILIA F.; STAURENGO-FERRARI, LARRISA; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; ANTUNES, MAISA M.; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-kappa B activation and cytokine production without antioxidant effects. Inflammation Research, v. 66, n. 7, p. 591-602, JUL 2017. Web of Science Citations: 2.
NASCIMENTO, DANIELE C.; MELO, PAULO H.; PINEROS, ANNIE R.; FERREIRA, RAPHAEL G.; COLON, DAVID F.; DONATE, PAULA B.; CASTANHEIRA, FERNANDA V.; GOZZI, ALINE; CZAIKOSKI, PAULA G.; NIEDBALA, WANDA; BORGES, MARCOS C.; ZAMBONI, DARIO S.; LIEW, FOO Y.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. NATURE COMMUNICATIONS, v. 8, APR 4 2017. Web of Science Citations: 40.
KANASHIRO, ALEXANDRE; SONEGO, FABIANE; FERREIRA, RAPHAEL G.; CASTANHEIRA, FERNANDA V. S.; LEITE, CAIO A.; BORGES, VANESSA F.; NASCIMENTO, DANIELE C.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; ULLOA, LUIS; CUNHA, FERNANDO Q. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. PHARMACOLOGICAL RESEARCH, v. 117, p. 1-8, MAR 2017. Web of Science Citations: 15.
TREVELIN, SILVIA C.; CARLOS, DANIELA; BERETTA, MATTEO; DA SILVA, JOAO S.; CUNHA, FERNANDO Q. Diabetes Mellitus and Sepsis: A Challenging Association. Shock, v. 47, n. 3, p. 276-287, MAR 2017. Web of Science Citations: 12.
FATTORI, VICTOR; SERAFIM, KARLA G. G.; ZARPELON, ANA C.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. Journal of Drug Targeting, v. 25, n. 3, p. 264-274, 2017. Web of Science Citations: 7.
FATTORI, VICTOR; HOHMANN, MIRIAM S. N.; ROSSANEIS, ANA C.; MANCHOPE, MARILIA F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; VERRI, JR., WALDICEU A. Targeting IL-33/ST2 signaling: regulation of immune function and analgesia. EXPERT OPINION ON THERAPEUTIC TARGETS, v. 21, n. 12, p. 1141-1152, 2017. Web of Science Citations: 10.
TREVELIN, SILVIA CELLONE; DOS SANTOS, CELIO XAVIER; FERREIRA, RAPHAEL GOMES; LIMA, LARISSA DE SA; SILVA, RANGEL LEAL; SCAVONE, CRISTOFORO; CURI, RUI; CARLOS ALVES-FILHO, JOSE; CUNHA, THIAGO MATTAR; ROXO-JUNIOR, PERSIO; CERVI, MARIA-CELIA; MARTINS LAURINDO, FRANCISCO RAFAEL; HOTHERSALL, JOHN STEPHEN; COBB, ANDREW M.; ZHANG, MIN; IVETIC, ALEKSANDAR; SHAH, AJAY M.; LOPES, LUCIA ROSSETTI; CUNHA, FERNANDO QUEIROZ. Apocynin and Nox2 regulate NF-kappa B by modifying thioredoxin-1 redox-state. SCIENTIFIC REPORTS, v. 6, OCT 4 2016. Web of Science Citations: 14.
BASSI, GABRIEL S.; MALVAR, DAVID DO C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; KANASHIRO, ALEXANDRE. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 389, n. 8, p. 851-861, AUG 2016. Web of Science Citations: 3.
SILVA, RANGEL L.; CASTANHEIRA, FERNANDA V.; FIGUEIREDO, JOZI G.; BASSI, GABRIEL S.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; KANASHIRO, ALEXANDRE. Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen. Inflammation, v. 39, n. 4, p. 1405-1413, AUG 2016. Web of Science Citations: 2.
PINHO-RIBEIRO, FELIPE A.; ZARPELON, ANA C.; MIZOKAMI, SANDRA S.; BORGHI, SERGIO M.; BORDIGNON, JULIANO; SILVA, RANGEL L.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-kappa B activation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 33, p. 8-14, JUL 2016. Web of Science Citations: 37.
FRANCA, RAFAEL F. O.; COSTA, RENATA S.; SILVA, JAQUELINE R.; PERES, RAPHAEL S.; MENDONCA, LEILA R.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. JOURNAL OF NEUROINFLAMMATION, v. 13, JUN 22 2016. Web of Science Citations: 14.
PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZARPELON, ANA C.; BORGHI, SERGIO M.; STAURENGO-FERRARI, LARISSA; CARVALHO, THACYANA T.; ALVES, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, WALDICEU A. Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-kappa B and oxidative stress. INFLAMMOPHARMACOLOGY, v. 24, n. 2-3, p. 97-107, JUN 2016. Web of Science Citations: 14.
SANT'ANNA, MORENA B.; KUSUDA, RICARDO; BOZZO, TIAGO A.; BASSI, GABRIEL S.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; SOUZA, GUILHERME R.; CUNHA, THIAGO M. Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. SCIENTIFIC REPORTS, v. 6, MAY 27 2016. Web of Science Citations: 6.
HUANG, LEI; OU, RONG; DE SOUZA, GUILHERME RABELO; CUNHA, THIAGO M.; LEMOS, HENRIQUE; MOHAMED, ESLAM; LI, LINGQIAN; PACHOLCZYK, GABRIELA; RANDALL, JANICE; MUNN, DAVID H.; MELLOR, ANDREW L. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLOS PATHOGENS, v. 12, n. 5 MAY 2016. Web of Science Citations: 12.
SANTA-CECILIA, FLAVIA V.; SOCIAS, BENJAMIN; OUIDJA, MOHAND O.; SEPULVEDA-DIAZ, JULIA E.; ACUNA, LEONARDO; SILVA, RANGEL L.; MICHEL, PATRICK P.; DEL-BEL, ELAINE; CUNHA, THIAGO M.; RAISMAN-VOZARI, RITA. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. NEUROTOXICITY RESEARCH, v. 29, n. 4, p. 447-459, MAY 2016. Web of Science Citations: 36.
SONEGO, FABIANE; CASTANHEIRA, FERNANDA VARGAS E SILVA; FERREIRA, RAPHAEL GOMES; KANASHIRO, ALEXANDRE; VITORINO GONCALVES LEITE, CAIO ABNER; NASCIMENTO, DANIELE CARVALHO; COLON, DAVID FERNANDO; BORGES, VANESSA DE FATIMA; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Paradoxical Roles of the neutrophil in Sepsis: Protective and Deleterious. FRONTIERS IN IMMUNOLOGY, v. 7, APR 26 2016. Web of Science Citations: 41.
ALVES-FILHO, JOSE C.; PALSSON-MCDERMOTT, EVA M. Pyruvate Kinase M2: A Potential Target for Regulating inflammation. FRONTIERS IN IMMUNOLOGY, v. 7, APR 21 2016. Web of Science Citations: 36.
CZAIKOSKI, PAULA GISELLE; SEGUNDO CORREIA MOTA, JOSE MAURCIO; NASCIMENTO, DANIELE CARVALHO; SONEGO, FABIANE; VARGAS E SILVA CASTANHEIRA, FERNANDA; MELO, PAULO HENRIQUE; SCORTEGAGNA, GABRIELA TRENTIN; SILVA, RANGEL LEAL; BARROSO-SOUSA, ROMUALDO; SOUTO, FABRICIO OLIVEIRA; PAZIN-FILHO, ANTONIO; FIGUEIREDO, FLORENCIO; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One, v. 11, n. 2 FEB 5 2016. Web of Science Citations: 73.
FRANCA, R. F. O.; VIEIRA, S. M.; TALBOT, J.; PERES, R. S.; PINTO, L. G.; ZAMBONI, D. S.; LOUZADA-JUNIOR, P.; CUNHA, F. Q.; CUNHA, T. M. Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v. 45, n. 1, p. 8-12, JAN 2 2016. Web of Science Citations: 6.
LOPES, ALEXANDRE H.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIANCHINI, GIANLUCA; SILVA, RANGEL L.; ZAPERLON, ANA C.; VERRI, JR., WALDICEU A.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; TEIXEIRA, MAURO M.; ALLEGRETTI, MARCELLO; CUNHA, THIAGO M. DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. PHARMACOLOGICAL RESEARCH, v. 103, p. 69-79, JAN 2016. Web of Science Citations: 7.
ZARPELON, ANA C.; RODRIGUES, FRANCIELLE C.; LOPES, ALEXANDRE H.; SOUZA, GUILHERME R.; CARVALHO, THACYANA T.; PINTO, LARISSA G.; XU, DAMO; FERREIRA, SERGIO H.; ALVES-FILHO, JOSE C.; MCINNES, IAIN B.; RYFFEL, BERNHARD; QUESNIAUX, VALERIE F. J.; REVERCHON, FLORA; MORTAUD, STEPHANE; MENUET, ARNAUD; LIEW, FOO Y.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; VERRI, JR., WALDICEU A. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB JOURNAL, v. 30, n. 1, p. 54-65, JAN 2016. Web of Science Citations: 51.
FATTORI, VICTOR; PINHO-RIBEIRO, FELIPE A.; BORGHI, SERGIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-kappa B activation. Inflammation Research, v. 64, n. 12, p. 993-1003, DEC 2015. Web of Science Citations: 31.
QUADROS, ANDREZA U.; PINTO, LARISSA G.; FONSECA, MIRIAM M.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; CUNHA, THIAGO M. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. SCIENTIFIC REPORTS, v. 5, OCT 29 2015. Web of Science Citations: 13.
VERAS, FLAVIO P.; PERES, RAPHAEL S.; SARAIVA, ANDRE L. L.; PINTO, LARISSA G.; LOUZADA-JUNIOR, PAULO; CUNHA, THIAGO M.; PASCHOAL, JONAS A. R.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. SCIENTIFIC REPORTS, v. 5, OCT 19 2015. Web of Science Citations: 21.
YAMACITA-BORIN, FABIANE Y.; ZARPELON, ANA C.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A. Superoxide anion-induced pain and inflammation depends on TNF alpha/TNFR1 signaling in mice. Neuroscience Letters, v. 605, p. 53-58, SEP 25 2015. Web of Science Citations: 23.
PINTO, LARISSA G.; TALBOT, JHIMMY; PERES, RAPHAEL S.; FRANCA, RAFAEL F.; FERREIRA, SERGIO H.; RYFFEL, BERNHARD; AVES-FILHO, JOSE CARLOS F.; FIGUEIREDO, FLORENCIO; CUNHA, THIAGO M.; CUNHA, FERNANDO Q. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1 beta production. ARTHRITIS RESEARCH & THERAPY, v. 17, SEP 2 2015. Web of Science Citations: 15.
SOUZA, GUILHERME R.; CUNHA, THIAGO M.; SILVA, RANGE L.; LOTUFO, CELINA M.; VERRI, JR., WALDICEU A.; FUNEZ, MANI I.; VILLARREAL, CHRISTIANE F.; TALBOT, JHIMMY; SOUSA, LIRLANDIA P.; PARADA, CARLOS A.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacology Biochemistry and Behavior, v. 134, p. 49-56, JUL 2015. Web of Science Citations: 8.
TALBOT, JHIMMY; BIANCHINI, FRANCINE J.; NASCIMENTO, DANILELE C.; OLIVEIRA, RENE D. R.; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PERES, RAPHAEL S.; SILVA, JAQUELINE R.; ALMEIDA, SERGIO C. L.; LOUZADA-JUNIOR, PAULO; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C. CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, v. 67, n. 7, p. 1751-1759, JUL 2015. Web of Science Citations: 37.
FREITAS, CRISTINA S.; ROVEDA, ANTONIO C.; TRUZZI, JR., DANIELA R.; GARCIA, ANDRE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; FRANCO, DOUGLAS W. Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands. Journal of Medicinal Chemistry, v. 58, n. 11, p. 4439-4448, JUN 11 2015. Web of Science Citations: 9.
FONSECA, MIRIAM D.; CUNHA, FERNANDO Q.; KASHFI, KHOSROW; CUNHA, THIAGO M. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. PHARMACOLOGY RESEARCH & PERSPECTIVES, v. 3, n. 3 JUN 2015. Web of Science Citations: 13.
PARRA, ROGERIO S.; LOPES, ALEXANDRE H.; CARREIRA, ELEONORA U.; FEITOSA, MARLEY R.; CUNHA, FERNANDO Q.; GARCIA, SERGIO B.; CUNHA, THIAGO M.; DA ROCHA, JOSE J. R.; FERES, OMAR. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. MEDICAL GAS RESEARCH, v. 5, APR 16 2015. Web of Science Citations: 7.
LOPES, ALEXANDRE H.; TALBOT, JHIMMY; SILVA, RANGEL L.; LIMA, JONILSON B.; FRANCA, RAFAEL O.; VERRI, JR., WALDICEU A.; MASCARENHAS, DANIELLE P.; RYFFEL, BERNHARD; CUNHA, FERNANDO Q.; ZAMBONI, DARIO S.; CUNHA, THIAGO M. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain, v. 156, n. 3, p. 451-459, MAR 2015. Web of Science Citations: 10.
PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; COSTA, DIEGO L.; DEMARQUE, DANIEL P.; GOUVEA, DAYANA RUBIO; LOPES, NORBERTO P.; QUEIROZ, REGINA HELENA C.; SILVA, JOAO SANTANA; FIGUEIREDO, FLORENCIO; ALVES-FILHO, JOSE CARLOS; CUNHA, THIAGO M.; FERREIRA, SERGIO H.; LOUZADA-JUNIOR, PAULO; CUNHA, FERNANDO Q. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 8, p. 2509-2514, FEB 24 2015. Web of Science Citations: 49.
TAMASHIRO, LETICIA FALEIROS; OLIVEIRA, RENE D. R.; OLIVEIRA, RODRIGO; COMINI FROTA, ELIZABETH REGINA; DONADI, EDUARDO ANTONIO; DEL-BEN, CRISTINA MARTA; TEIXEIRA, ANTONIO LUCIO; LOUZADA-JUNIOR, PAULO. Participation of the neutrophin brain-derived neurotrophic factor in neuropsychiatric systemic lupus erythematosus. RHEUMATOLOGY, v. 53, n. 12, p. 2182-2190, DEC 2014. Web of Science Citations: 6.
MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; BIANCHINI, GIANLUCA; BECCARI, ANDREA R.; FANTON, MARCO; BRUNO, AGOSTINO; COSTANTINO, GABRIELE; BERTINI, RICCARDO; GALLIERA, EMANUELA; LOCATI, MASSIMO; FERREIRA, SERGIO H.; TEIXEIRA, MAURO M.; ALLEGRETTI, MARCELLO. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proceedings of the National Academy of Sciences of the United States of America, v. 111, n. 47, p. 16937-16942, NOV 25 2014. Web of Science Citations: 25.
BARRAGAN-IGLESIAS, PAULINO; ROCHA-GONZALEZ, HECTOR I.; BARUCH PINEDA-FARIAS, JORGE; MURBARTIAN, JANET; GODINEZ-CHAPARRO, BEATRIZ; REINACH, PETER S.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; GRANADOS-SOTO, VINICIO. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. European Journal of Pharmacology, v. 738, p. 91-100, SEP 5 2014. Web of Science Citations: 4.
SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; CZAIKOSKI, PAULA G.; KANASHIRO, ALEXANDRE; SOUTO, FABRICIO O.; FRANCA, RAFAEL O.; NASCIMENTO, DANIELE C.; FREITAS, ANDRESSA; SPILLER, FERNANDO; CUNHA, LARISSA D.; ZAMBONI, DARIO S.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q. MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response. PLoS One, v. 9, n. 8 AUG 1 2014. Web of Science Citations: 8.
SONEGO, FABIANE; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Targeting neutrophils in sepsis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, v. 10, n. 8, p. 1019-1028, AUG 2014. Web of Science Citations: 15.
VIEIRA, SILVIO MANFREDO; SILVA, RANGEL LEAL; LEMOS, HENRIQUE PAULA; DAS NEVES AMORIM, RODRIGO CESAR; COSTA SILVA, ELLEN CRISTINA; REINACH, PETER SOL; CUNHA, FERNANDO QUEIROZ; POHLIT, ADRIAN MARTIN; CUNHA, THIAGO MATTAR. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, v. 95, p. 8-15, JUN 2014. Web of Science Citations: 3.
CALIL, IGOR L.; ZARPELON, ANA C.; GUERRERO, ANA T. G.; ALVES-FILHO, JOSE C.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; VERRI, JR., WALDICEU A. Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw. PLoS One, v. 9, n. 3 MAR 3 2014. Web of Science Citations: 43.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

MÉTODO DE AVALIAÇÃO DA PREDIÇÃO DA RESPOSTA TERAPÊUTICA DE UM INDIVÍDUO A UM DADO MEDICAMENTO E KITS PARA SUA REALIZAÇÃO BR1020130109967 - Universidade de São Paulo (USP) . Fernando de Queiroz Cunha; Raphael Sanches Peres; José Carlos Farias Alves Filho; Thiago Mattar Cunha; Jhimmy Talbot; Paulo Louzada Junior; Vanessa Carregaro Pereira - May 2013, 03

Distribution map of accesses to this page
Click here to view the access summary to this page.