Research Grants 11/19670-0 - Inflamação, Dor - BV FAPESP
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Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis

Grant number: 11/19670-0
Support Opportunities:Research Projects - Thematic Grants
Field of knowledge:Biological Sciences - Pharmacology - General Pharmacology
Principal Investigator:Fernando de Queiroz Cunha
Grantee:Fernando de Queiroz Cunha
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
( Últimos )
José Carlos Farias Alves Filho ; Paulo Louzada Junior ; Thiago Mattar Cunha
Pesquisadores principais:
( Antigos )
Sérgio Henrique Ferreira
Associated research grant(s):13/09434-3 - Immunopharmacological salivary modulators from hematophagous arthropods, AV.EXT
Associated scholarship(s):15/22182-9 - The role of the transient receptor potencial vanilloid-1 in the induction and maintenance of herpetic- and post-herpetic neuralgia, BP.IC
14/09008-7 - The role of pattern recognition receptors like toll-like receptors 4 in the induction and maintenance of herpetic and post-herpetic neuralgia, BP.PD
13/15316-3 - Investigation of the protective role of interleukin 27 (IL-27) on the genesis and maintenance of neuropathic pain, BP.DR
+ associated scholarships 13/04942-0 - Molecular mechanisms involved in the enhancement of Th17 response by aryl hydrocarbon receptor (AHR) - correlation with rheumatoid arthritis, BP.DR
13/07968-0 - The role of indoleamine 2,3-dioxygenase in supraspinal structures in the induction and maintenance of neuropathic pain, BP.MS
13/03758-1 - Role of D6 receptor in development and maintenance of chronic neuropathic pain, BP.DR
12/04076-9 - Role of the aryl hydrocarbon receptor (AhR) in the pathogenesis of sepsis, BP.PD
12/04132-6 - Role of D6 receptor in the inflammatory response development during sepsis, BP.DR
11/13097-7 - Role of indoleamine 2,3-dioxygenase in the induction and maintenance of neuropathic pain, BP.PD - associated scholarships

Abstract

For the past 25 years, our group has been studying the physiopathological mechanisms involved in the inflammatory process. In order to continue doing so, in this project we seek to do translational research regarding inflammatory diseases, mainly rheumatoid arthritis, chronic pain and sepsis. All three topics will be investigated in an integrated stand: 1) mechanisms involved in recognizing the triggering agents, focusing in pattern recognition receptors (TLRs and NLRs), their endogenous ligands and the activation of recognition cells (dendritic cells, glial cell, mastocytes, synoviocytes); 2) effector mechanisms, especially regarding cytokines and chemokines roles and their receptors, and effector cells (neutrophils, lymphocytes and macrophages); intracellular signaling, including intracellular receptors (AhR, PPARgama, LXR) and transcription factors (NFkB, AP-1, CREB); and finally 4) immune response modulators, focusing in adenosine, Indoleamine 2,3-dioxygenase, eicosanoids and co-stimulatory molecule CD28. Developing this project will allow the identification of new common biological target to most of the three aforementioned topics, leading to the development of new biological markers and treatment schemes for those diseases. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (77)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proceedings of the National Academy of Sciences of the United States of America, v. 111, n. 47, p. 16937-16942, . (13/08216-2, 11/19670-0)
PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 8, p. 2509-2514, . (13/08216-2, 11/19670-0)
SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. Science Signaling, v. 11, n. 528, . (13/08216-2, 11/19670-0)
MEDEIROS, PRISCILA; DOS SANTOS, IEDA REGINA; MATIAS JUNIOR, IVAIR; PALAZZO, ENZA; DA SILVA, JOSE APARECIDO; MACHADO, HELIO RUBENS; FERREIRA, SERGIO HENRIQUE; MAIONE, SABATINO; COIMBRA, NORBERTO CYSNE; DE FREITAS, RENATO LEONARDO. An Adapted Chronic Constriction Injury of the Sciatic Nerve Produces Sensory, Affective, and Cognitive Impairments: A Peripheral Mononeuropathy Model for the Study of Comorbid Neuropsychiatric Disorders Associated with Neuropathic Pain in Rats. PAIN MEDICINE, v. 22, n. 2, p. 338-351, . (11/19670-0, 13/08216-2, 13/12916-0, 17/13560-5, 14/11869-0, 12/25167-2, 14/07902-2, 09/17258-5)
SILVA, CASSIA R.; MELO, BRUNO M. S.; SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; PEREIRA, JANAINA A.; CECILIO, NERRY T.; BERLINK, JONILSON; SOUZA, GIOVANI G.; LUCAS, GUILHERME; VOGL, THOMAS; et al. S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway. BRAIN BEHAVIOR AND IMMUNITY, v. 88, p. 353-362, . (13/08216-2, 11/19670-0)
CECILIO, NERRY T.; SOUZA, GUILHERME R.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. The PI3K gamma/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 35, n. 2, p. 364-370, . (13/08216-2, 11/19670-0)
SARAIVA, ANDRE L.; VERAS, FLAVIO P.; PERES, RAPHAEL S.; TALBOT, JHIMMY; DE LIMA, KALIL A.; LUIZ, JOAO P.; CARBALLIDO, JOSE M.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; RYFFEL, BERNHARD; et al. Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of T(h)17 cells in the lymph nodes. FASEB JOURNAL, v. 32, n. 12, p. 6550-6558, . (13/08216-2, 11/19670-0)
MANCHOPE, MARILIA F.; ARTERO, NAYARA A.; FATTORI, VICTOR; MIZOKAMI, SANDRA S.; PITOL, DIMITRIUS L.; ISSA, JOAO P. M.; FUKADA, SANDRA Y.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; et al. Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NF kappa B. Inflammation Research, v. 67, n. 11-12, p. 997-1012, . (13/08216-2, 11/19670-0)
SANTA-CECILIA, V, FLAVIA; FERREIRA, DAVID W.; GUIMARAES, RAFAELA M.; CECILIO, NERRY T.; FONSECA, MIRIAM M.; LOPES, ALEXANDRE H.; DAVOLI-FERREIRA, MARCELA; KUSUDA, RICARDO; SOUZA, GUILHERME R.; NACHBUR, UELI; et al. The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development. Pain, v. 160, n. 1, p. 102-116, . (13/08216-2, 11/19670-0)
TREVELIN, SILVIA C.; CARLOS, DANIELA; BERETTA, MATTEO; DA SILVA, JOAO S.; CUNHA, FERNANDO Q.. Diabetes Mellitus and Sepsis: A Challenging Association. Shock, v. 47, n. 3, p. 276-287, . (13/08216-2, 11/03293-3, 11/19670-0, 09/54764-6)
SILVA CASTANHEIRA, FERNANDA V. E; BORGES, VANESSA; SONEGO, FABIANE; KANASHIRO, ALEXANDRE; DONATE, PAULA B.; MELO, PAULO H.; PALLAS, KENNETH; RUSSO, REMO C.; AMARAL, FLAVIO A.; TEIXEIRA, MAURO M.; et al. THE ATYPICAL CHEMOKINE RECEPTOR ACKR2 IS PROTECTIVE AGAINST SEPSIS. Shock, v. 49, n. 6, p. 682-689, . (13/08216-2, 11/19670-0)
P. MEDEIROS; I.R. DOS SANTOS; A.C. MEDEIROS; J.A. DA SILVA; S.H. FERREIRA; R.L. DE FREITAS; N.C. COIMBRA. Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. Brazilian Journal of Medical and Biological Research, v. 53, n. 5, . (09/17258-5, 13/12916-0, 14/11869-0, 17/13560-5, 13/08216-2, 12/25167-2, 14/07902-2, 11/19670-0)
KANASHIRO, ALEXANDRE; HIROKI, CARLOS HIROJI; DA FONSECA, DENISE MORAIS; BIRBRAIR, ALEXANDER; FERREIRA, RAPHAEL GOMES; BASSI, GABRIEL SHIMIZU; FONSECA, MIRIAN D.; KUSUDA, RICARDO; MARTELOSSI CEBINELLI, GUILHERME CESAR; DA SILVA, KATIUSSIA PINHO; et al. The role of neutrophils in neuro-immune modulation. PHARMACOLOGICAL RESEARCH, v. 151, . (16/08385-7, 13/08216-2, 11/20343-4, 11/19670-0, 12/04237-2)
MEDEIROS, PRISCILA; NEGRINI-FERRARI, SYLMARA ESTHER; PALAZZO, ENZA; MAIONE, SABATINO; FERREIRA, SERGIO HENRIQUE; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain. Neurochemical Research, v. 44, n. 9, p. 2068-2080, . (14/11869-0, 12/25167-2, 13/08216-2, 13/12916-0, 11/19670-0, 17/13560-5, 09/17258-5, 14/07902-2)
SONEGO, FABIANE; CASTANHEIRA, FERNANDA VARGAS E SILVA; FERREIRA, RAPHAEL GOMES; KANASHIRO, ALEXANDRE; VITORINO GONCALVES LEITE, CAIO ABNER; NASCIMENTO, DANIELE CARVALHO; COLON, DAVID FERNANDO; BORGES, VANESSA DE FATIMA; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Paradoxical Roles of the neutrophil in Sepsis: Protective and Deleterious. FRONTIERS IN IMMUNOLOGY, v. 7, . (08/11593-4, 11/19670-0)
ALVES-FILHO, JOSE C.; PALSSON-MCDERMOTT, EVA M.. Pyruvate Kinase M2: A Potential Target for Regulating inflammation. FRONTIERS IN IMMUNOLOGY, v. 7, . (13/08216-2, 11/19670-0)
TALBOT, JHIMMY; PERES, RAPHAEL S.; PINTO, LARISSA G.; OLIVEIRA, RENE D. R.; LIMA, KALIL A.; DONATE, PAULA B.; SILVA, JAQUELINE R.; RYFFEL, BERNARD; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; et al. Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells. ARTHRITIS RESEARCH & THERAPY, v. 20, . (13/08216-2, 11/19670-0)
FRANCA, R. F. O.; VIEIRA, S. M.; TALBOT, J.; PERES, R. S.; PINTO, L. G.; ZAMBONI, D. S.; LOUZADA-JUNIOR, P.; CUNHA, F. Q.; CUNHA, T. M.. Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v. 45, n. 1, p. 8-12, . (10/19770-2, 13/08216-2, 11/19670-0)
CZAIKOSKI, PAULA GISELLE; SEGUNDO CORREIA MOTA, JOSE MAURCIO; NASCIMENTO, DANIELE CARVALHO; SONEGO, FABIANE; VARGAS E SILVA CASTANHEIRA, FERNANDA; MELO, PAULO HENRIQUE; SCORTEGAGNA, GABRIELA TRENTIN; SILVA, RANGEL LEAL; BARROSO-SOUSA, ROMUALDO; SOUTO, FABRICIO OLIVEIRA; et al. Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One, v. 11, n. 2, . (13/08216-2, 11/19670-0)
ZARPELON, ANA C.; RODRIGUES, FRANCIELLE C.; LOPES, ALEXANDRE H.; SOUZA, GUILHERME R.; CARVALHO, THACYANA T.; PINTO, LARISSA G.; XU, DAMO; FERREIRA, SERGIO H.; ALVES-FILHO, JOSE C.; MCINNES, IAIN B.; et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB JOURNAL, v. 30, n. 1, p. 54-65, . (13/08216-2, 11/19670-0)
SANTA-CECILIA, FLAVIA V.; SOCIAS, BENJAMIN; OUIDJA, MOHAND O.; SEPULVEDA-DIAZ, JULIA E.; ACUNA, LEONARDO; SILVA, RANGEL L.; MICHEL, PATRICK P.; DEL-BEL, ELAINE; CUNHA, THIAGO M.; RAISMAN-VOZARI, RITA. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. NEUROTOXICITY RESEARCH, v. 29, n. 4, p. 447-459, . (13/08216-2, 11/19670-0)
SILVA, RANGEL L.; CASTANHEIRA, FERNANDA V.; FIGUEIREDO, JOZI G.; BASSI, GABRIEL S.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; KANASHIRO, ALEXANDRE. Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen. Inflammation, v. 39, n. 4, p. 1405-1413, . (13/08216-2, 11/20343-4, 11/19670-0, 13/01466-3, 12/04237-2)
STAURENGO-FERRARI, LARISSA; TREVELIN, SILVIA C.; FATTORI, VICTOR; NASCIMENTO, DANIELE C.; DE LIMA, KALIL A.; PELAYO, JACINTA S.; FIGUEIREDO, FLORENCIO; CASAGRANDE, RUBIA; FUKADA, SANDRA Y.; TEIXEIRA, MAURO M.; et al. Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-lnduced Septic Arthritis. FRONTIERS IN IMMUNOLOGY, v. 9, . (13/08216-2, 11/19670-0)
HUANG, LEI; OU, RONG; DE SOUZA, GUILHERME RABELO; CUNHA, THIAGO M.; LEMOS, HENRIQUE; MOHAMED, ESLAM; LI, LINGQIAN; PACHOLCZYK, GABRIELA; RANDALL, JANICE; MUNN, DAVID H.; et al. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLOS PATHOGENS, v. 12, n. 5, . (13/08216-2, 11/19670-0)
BASSI, GABRIEL S.; MALVAR, DAVID DO C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; KANASHIRO, ALEXANDRE. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 389, n. 8, p. 851-861, . (13/08216-2, 12/04237-2, 11/19670-0, 11/20343-4)
TREVELIN, SILVIA CELLONE; DOS SANTOS, CELIO XAVIER; FERREIRA, RAPHAEL GOMES; LIMA, LARISSA DE SA; SILVA, RANGEL LEAL; SCAVONE, CRISTOFORO; CURI, RUI; CARLOS ALVES-FILHO, JOSE; CUNHA, THIAGO MATTAR; ROXO-JUNIOR, PERSIO; et al. Apocynin and Nox2 regulate NF-kappa B by modifying thioredoxin-1 redox-state. SCIENTIFIC REPORTS, v. 6, . (12/24677-7, 09/54764-6, 13/08216-2, 13/03520-5, 11/19670-0, 11/03293-3, 13/07937-8)
PINEROS ALVAREZ, ANNIE ROCIO; GLOSSON-BYERS, NICOLE; BRANDT, STEPHANIE; WANG, SOUJUAN; WONG, HECTOR; STURGEON, SARAH; MCCARTHY, BRIAN PAUL; TERRITO, PAUL R.; ALVES-FILHO, JOSE CARLOS; HENRIQUE SEREZANI, C.. SOCS1 is a negative regulator of metabolic reprogramming during sepsis. JCI INSIGHT, v. 2, n. 13, . (13/08216-2, 11/19670-0)
PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZARPELON, ANA C.; BORGHI, SERGIO M.; STAURENGO-FERRARI, LARISSA; CARVALHO, THACYANA T.; ALVES, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; et al. Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-kappa B and oxidative stress. INFLAMMOPHARMACOLOGY, v. 24, n. 2-3, p. 97-107, . (13/08216-2, 11/19670-0)
PINHO-RIBEIRO, FELIPE A.; ZARPELON, ANA C.; MIZOKAMI, SANDRA S.; BORGHI, SERGIO M.; BORDIGNON, JULIANO; SILVA, RANGEL L.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; et al. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-kappa B activation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 33, p. 8-14, . (13/08216-2, 11/19670-0)
FRANCA, RAFAEL F. O.; COSTA, RENATA S.; SILVA, JAQUELINE R.; PERES, RAPHAEL S.; MENDONCA, LEILA R.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. JOURNAL OF NEUROINFLAMMATION, v. 13, . (10/19770-2, 13/08216-2, 11/19670-0)
YAMACITA-BORIN, FABIANE Y.; ZARPELON, ANA C.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Superoxide anion-induced pain and inflammation depends on TNF alpha/TNFR1 signaling in mice. Neuroscience Letters, v. 605, p. 53-58, . (13/08216-2, 11/19670-0)
FATTORI, VICTOR; PINHO-RIBEIRO, FELIPE A.; BORGHI, SERGIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-kappa B activation. Inflammation Research, v. 64, n. 12, p. 993-1003, . (13/08216-2, 11/19670-0)
BARRAGAN-IGLESIAS, PAULINO; ROCHA-GONZALEZ, HECTOR I.; BARUCH PINEDA-FARIAS, JORGE; MURBARTIAN, JANET; GODINEZ-CHAPARRO, BEATRIZ; REINACH, PETER S.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; GRANADOS-SOTO, VINICIO. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. European Journal of Pharmacology, v. 738, p. 91-100, . (11/19670-0)
SONEGO, FABIANE; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Targeting neutrophils in sepsis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, v. 10, n. 8, p. 1019-1028, . (13/08216-2, 11/19670-0)
VIEIRA, SILVIO MANFREDO; SILVA, RANGEL LEAL; LEMOS, HENRIQUE PAULA; DAS NEVES AMORIM, RODRIGO CESAR; COSTA SILVA, ELLEN CRISTINA; REINACH, PETER SOL; CUNHA, FERNANDO QUEIROZ; POHLIT, ADRIAN MARTIN; CUNHA, THIAGO MATTAR. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, v. 95, p. 8-15, . (11/19670-0)
CALIL, IGOR L.; ZARPELON, ANA C.; GUERRERO, ANA T. G.; ALVES-FILHO, JOSE C.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; VERRI, JR., WALDICEU A.. Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw. PLoS One, v. 9, n. 3, . (11/19670-0)
ZARPELON, ANA C.; FATTORI, VICTOR; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PINHO-RIBEIRO, FELIPE A.; RUIZ-MIYAZAWA, KENJI W.; TURATO, WALTER M.; CUNHA, THIAGO M.; DA COSTA, FERNANDO B.; CUNHA, FERNANDO Q.; et al. The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-kappa B and Cytokines. Inflammation, v. 40, n. 6, p. 2020-2032, . (13/08216-2, 11/19670-0)
FATTORI, VICTOR; HOHMANN, MIRIAM S. N.; ROSSANEIS, ANA C.; MANCHOPE, MARILIA F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; VERRI, JR., WALDICEU A.. Targeting IL-33/ST2 signaling: regulation of immune function and analgesia. EXPERT OPINION ON THERAPEUTIC TARGETS, v. 21, n. 12, p. 1141-1152, . (13/08216-2, 11/19670-0)
LOPES, ALEXANDRE H.; TALBOT, JHIMMY; SILVA, RANGEL L.; LIMA, JONILSON B.; FRANCA, RAFAEL O.; VERRI, JR., WALDICEU A.; MASCARENHAS, DANIELLE P.; RYFFEL, BERNHARD; CUNHA, FERNANDO Q.; ZAMBONI, DARIO S.; et al. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain, v. 156, n. 3, p. 451-459, . (13/08216-2, 11/19670-0)
FREITAS, CRISTINA S.; ROVEDA, ANTONIO C.; TRUZZI, JR., DANIELA R.; GARCIA, ANDRE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; FRANCO, DOUGLAS W.. Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands. Journal of Medicinal Chemistry, v. 58, n. 11, p. 4439-4448, . (12/23651-4, 13/08216-2, 11/19670-0)
SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; TALBOT, JHIMMY; CECILIO, NERRY T.; ROSSATO, MATEUS F.; SILVA, RANGEL L.; SOUZA, GUILHERME R.; SILVA, CASSIA R.; LUCAS, GUILHERME; FONSECA, BENEDITO A.; et al. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. JOURNAL OF NEUROSCIENCE, v. 37, n. 27, p. 6408-6422, . (10/12309-8, 13/08216-2, 11/19670-0)
HIROKI, CARLOS H.; TOLLER-KAWAHISA, JULIANA E.; FUMAGALLI, MARCILIO J.; COLON, DAVID F.; FIGUEIREDO, LUIZ T. M.; FONSECA, BENDITO A. L. D.; FRANCA, RAFAEL F. O.; CUNHA, FERNANDO Q.. Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection. FRONTIERS IN IMMUNOLOGY, v. 10, . (13/08216-2, 11/19670-0)
MAGANIN, ALEXANDRE G.; SOUZA, GUILHERME R.; FONSECA, MIRIAM D.; LOPES, ALEXANDRE H.; GUIMARAES, RAFAELA M.; DAGOSTIN, ANDRE; CECILIO, NERRY T.; MENDES, ATLANTE S.; GONCALVES, WILLIAM A.; SILVA, CONCEICAO E. A.; et al. Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice. Journal of Clinical Investigation, v. 132, n. 23, p. 17-pg., . (13/08216-2, 11/19670-0)
LOPES, ALEXANDRE H.; SILVA, RANGEL L.; FONSECA, MIRIAM D.; GOMES, FRANCISCO I.; MAGANIN, ALEXANDRE G.; RIBEIRO, LUCAS S.; MARQUES, LUCAS MACIEL MAURIZ; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; ZAMBONI, DARIO S.; et al. Molecular basis of carrageenan-induced cytokines production in macrophages. CELL COMMUNICATION AND SIGNALING, v. 18, n. 1, p. 17-pg., . (13/08216-2, 11/19670-0)
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GUIMARAESI, RAFAELA M.; DAVOLI-FERREIRA, MARCELA; FONSECA, MIRIAM M.; DAMASCENO, LUIS EDUARDO A.; SANTA-CECILIA, V, FLAVIA; KUSUDA, RICARDO; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.. Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury. Journal of Leukocyte Biology, v. 106, n. 3, SI, p. 541-551, . (13/08216-2, 11/19670-0)
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KANASHIRO, ALEXANDRE; SONEGO, FABIANE; FERREIRA, RAPHAEL G.; CASTANHEIRA, FERNANDA V. S.; LEITE, CAIO A.; BORGES, VANESSA F.; NASCIMENTO, DANIELE C.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; ULLOA, LUIS; et al. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. PHARMACOLOGICAL RESEARCH, v. 117, p. 1-8, . (13/08216-2, 12/04237-2, 11/19670-0, 11/20343-4)
RUIZ-MIYAZAWA, KENJI W.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; STAURENGO-FERRARI, LARISSA; FATTORI, VICTOR; FERNANDES, GLAURA S. A.; CASELLA, ANTONIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF kappa B and macrophage release of IL-1 beta. Journal of Functional Foods, v. 48, p. 106-116, . (13/08216-2, 11/19670-0, 10/15014-9)
BERTOZZI, MARIANA M.; ROSSANEIS, ANA C.; FATTORI, VICTOR; LONGHI-BALBINOT, DANIELA T.; FREITAS, ANDRESSA; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. Chemico-Biological Interactions, v. 273, p. 180-189, . (13/08216-2, 11/19670-0)
PARRA, ROGERIO S.; LOPES, ALEXANDRE H.; CARREIRA, ELEONORA U.; FEITOSA, MARLEY R.; CUNHA, FERNANDO Q.; GARCIA, SERGIO B.; CUNHA, THIAGO M.; DA ROCHA, JOSE J. R.; FERES, OMAR. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. MEDICAL GAS RESEARCH, v. 5, . (11/19670-0)
ZUCOLOTO, AMANDA Z.; MANCHOPE, MARILIA F.; STAURENGO-FERRARI, LARRISA; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; ANTUNES, MAISA M.; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-kappa B activation and cytokine production without antioxidant effects. Inflammation Research, v. 66, n. 7, p. 591-602, . (13/08216-2, 11/19670-0)
SOUZA, GUILHERME R.; CUNHA, THIAGO M.; SILVA, RANGE L.; LOTUFO, CELINA M.; VERRI, JR., WALDICEU A.; FUNEZ, MANI I.; VILLARREAL, CHRISTIANE F.; TALBOT, JHIMMY; SOUSA, LIRLANDIA P.; PARADA, CARLOS A.; et al. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacology Biochemistry and Behavior, v. 134, p. 49-56, . (13/08216-2, 11/19670-0)
TALBOT, JHIMMY; BIANCHINI, FRANCINE J.; NASCIMENTO, DANILELE C.; OLIVEIRA, RENE D. R.; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PERES, RAPHAEL S.; SILVA, JAQUELINE R.; ALMEIDA, SERGIO C. L.; LOUZADA-JUNIOR, PAULO; et al. CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, v. 67, n. 7, p. 1751-1759, . (13/08216-2, 11/19670-0)
PINTO, LARISSA G.; TALBOT, JHIMMY; PERES, RAPHAEL S.; FRANCA, RAFAEL F.; FERREIRA, SERGIO H.; RYFFEL, BERNHARD; AVES-FILHO, JOSE CARLOS F.; FIGUEIREDO, FLORENCIO; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1 beta production. ARTHRITIS RESEARCH & THERAPY, v. 17, . (13/08216-2, 11/19670-0)
TAMASHIRO, LETICIA FALEIROS; OLIVEIRA, RENE D. R.; OLIVEIRA, RODRIGO; COMINI FROTA, ELIZABETH REGINA; DONADI, EDUARDO ANTONIO; DEL-BEN, CRISTINA MARTA; TEIXEIRA, ANTONIO LUCIO; LOUZADA-JUNIOR, PAULO. Participation of the neutrophin brain-derived neurotrophic factor in neuropsychiatric systemic lupus erythematosus. RHEUMATOLOGY, v. 53, n. 12, p. 2182-2190, . (13/08216-2, 11/19670-0)
SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; CZAIKOSKI, PAULA G.; KANASHIRO, ALEXANDRE; SOUTO, FABRICIO O.; FRANCA, RAFAEL O.; NASCIMENTO, DANIELE C.; FREITAS, ANDRESSA; SPILLER, FERNANDO; CUNHA, LARISSA D.; et al. MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response. PLoS One, v. 9, n. 8, . (08/11593-4, 11/19670-0)
SANT'ANNA, MORENA B.; KUSUDA, RICARDO; BOZZO, TIAGO A.; BASSI, GABRIEL S.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; SOUZA, GUILHERME R.; CUNHA, THIAGO M.. Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. SCIENTIFIC REPORTS, v. 6, . (13/08216-2, 11/19670-0)
VERAS, FLAVIO P.; PERES, RAPHAEL S.; SARAIVA, ANDRE L. L.; PINTO, LARISSA G.; LOUZADA-JUNIOR, PAULO; CUNHA, THIAGO M.; PASCHOAL, JONAS A. R.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. SCIENTIFIC REPORTS, v. 5, . (13/08216-2, 09/54014-7, 11/19670-0)
QUADROS, ANDREZA U.; PINTO, LARISSA G.; FONSECA, MIRIAM M.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. SCIENTIFIC REPORTS, v. 5, . (13/08216-2, 09/54014-7, 11/19670-0)
LOPES, ALEXANDRE H.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIANCHINI, GIANLUCA; SILVA, RANGEL L.; ZAPERLON, ANA C.; VERRI, JR., WALDICEU A.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; TEIXEIRA, MAURO M.; et al. DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. PHARMACOLOGICAL RESEARCH, v. 103, p. 69-79, . (13/08216-2, 11/19670-0)
DAVOLI-FERREIRA, MARCELA; DE LIMA, KALIL A.; FONSECA, MIRIAM M.; GUIMARAES, RAFAELA M.; GOMES, I, FRANCISCO; CAVALLINI, MARIA C.; QUADROS, ANDREZA U.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; et al. Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury. Pain, v. 161, n. 8, p. 1730-1743, . (13/08216-2, 11/19670-0)
PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 112, n. 8, p. 6-pg., . (13/08216-2, 11/19670-0)
SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. SCIENCE SIGNALING, v. 11, n. 528, p. 14-pg., . (13/08216-2, 11/19670-0)
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LOURENCO-GONZALEZ, YURI; FATTORI, VICTOR; DOMICIANO, TALITA P.; ROSSANEIS, ANA C.; BORGHI, SERGIO M.; ZANINELLI, TIAGO H.; BERNARDY, CATIA C. F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation, v. 2019, p. 14-pg., . (13/08216-2, 11/19670-0)

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MÉTODO DE AVALIAÇÃO DA PREDIÇÃO DA RESPOSTA TERAPÊUTICA DE UM INDIVÍDUO A UM DADO MEDICAMENTO E KITS PARA SUA REALIZAÇÃO BR1020130109967 - Universidade de São Paulo (USP) . Fernando de Queiroz Cunha ; Raphael Sanches Peres ; José Carlos Farias Alves Filho ; Thiago Mattar Cunha ; Jhimmy Talbot ; Paulo Louzada Junior ; Vanessa Carregaro Pereira - May 2013, 03