Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis

• Grant number: 11/19670-0
• Support Opportunities: Research Projects - Thematic Grants
• Duration: May 01, 2012 - June 30, 2017
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Fernando de Queiroz Cunha
• Grantee: Fernando de Queiroz Cunha
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais:( Últimos ): José Carlos Farias Alves Filho ; Paulo Louzada Junior ; Thiago Mattar Cunha
• Pesquisadores principais:( Antigos ): Sérgio Henrique Ferreira
• Associated grant(s): 13/09434-3 - Immunopharmacological salivary modulators from hematophagous arthropods, AV.EXT
• Associated scholarship(s): 15/22182-9 - The role of the transient receptor potencial vanilloid-1 in the induction and maintenance of herpetic- and post-herpetic neuralgia, BP.IC; 14/09008-7 - The role of pattern recognition receptors like toll-like receptors 4 in the induction and maintenance of herpetic and post-herpetic neuralgia, BP.PD; 13/15316-3 - Investigation of the protective role of interleukin 27 (IL-27) on the genesis and maintenance of neuropathic pain, BP.DR; + associated scholarships 13/04942-0 - Molecular mechanisms involved in the enhancement of Th17 response by aryl hydrocarbon receptor (AHR) - correlation with rheumatoid arthritis, BP.DR; 13/07968-0 - The role of indoleamine 2,3-dioxygenase in supraspinal structures in the induction and maintenance of neuropathic pain, BP.MS; 13/03758-1 - Role of D6 receptor in development and maintenance of chronic neuropathic pain, BP.DR; 12/04132-6 - Role of D6 receptor in the inflammatory response development during sepsis, BP.DR; 12/04076-9 - Role of the aryl hydrocarbon receptor (AhR) in the pathogenesis of sepsis, BP.PD; 11/13097-7 - Role of indoleamine 2,3-dioxygenase in the induction and maintenance of neuropathic pain, BP.PD - associated scholarships

Abstract

For the past 25 years, our group has been studying the physiopathological mechanisms involved in the inflammatory process. In order to continue doing so, in this project we seek to do translational research regarding inflammatory diseases, mainly rheumatoid arthritis, chronic pain and sepsis. All three topics will be investigated in an integrated stand: 1) mechanisms involved in recognizing the triggering agents, focusing in pattern recognition receptors (TLRs and NLRs), their endogenous ligands and the activation of recognition cells (dendritic cells, glial cell, mastocytes, synoviocytes); 2) effector mechanisms, especially regarding cytokines and chemokines roles and their receptors, and effector cells (neutrophils, lymphocytes and macrophages); intracellular signaling, including intracellular receptors (AhR, PPARgama, LXR) and transcription factors (NFkB, AP-1, CREB); and finally 4) immune response modulators, focusing in adenosine, Indoleamine 2,3-dioxygenase, eicosanoids and co-stimulatory molecule CD28. Developing this project will allow the identification of new common biological target to most of the three aforementioned topics, leading to the development of new biological markers and treatment schemes for those diseases. (AU)

Scientific publications

(69)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CZAIKOSKI, PAULA GISELLE; SEGUNDO CORREIA MOTA, JOSE MAURCIO; NASCIMENTO, DANIELE CARVALHO; SONEGO, FABIANE; VARGAS E SILVA CASTANHEIRA, FERNANDA; MELO, PAULO HENRIQUE; SCORTEGAGNA, GABRIELA TRENTIN; SILVA, RANGEL LEAL; BARROSO-SOUSA, ROMUALDO; SOUTO, FABRICIO OLIVEIRA; et al. Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One, v. 11, n. 2, FEB 5 2016. (13/08216-2, 11/19670-0)

SILVA, RANGEL L.; CASTANHEIRA, FERNANDA V.; FIGUEIREDO, JOZI G.; BASSI, GABRIEL S.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; KANASHIRO, ALEXANDRE. Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen. Inflammation, v. 39, n. 4, p. 1405-1413, AUG 2016. (13/08216-2, 11/20343-4, 11/19670-0, 13/01466-3, 12/04237-2)

ZARPELON, ANA C.; RODRIGUES, FRANCIELLE C.; LOPES, ALEXANDRE H.; SOUZA, GUILHERME R.; CARVALHO, THACYANA T.; PINTO, LARISSA G.; XU, DAMO; FERREIRA, SERGIO H.; ALVES-FILHO, JOSE C.; MCINNES, IAIN B.; et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB JOURNAL, v. 30, n. 1, p. 54-65, JAN 2016. (13/08216-2, 11/19670-0)

TREVELIN, SILVIA CELLONE; DOS SANTOS, CELIO XAVIER; FERREIRA, RAPHAEL GOMES; LIMA, LARISSA DE SA; SILVA, RANGEL LEAL; SCAVONE, CRISTOFORO; CURI, RUI; CARLOS ALVES-FILHO, JOSE; CUNHA, THIAGO MATTAR; ROXO-JUNIOR, PERSIO; et al. Apocynin and Nox2 regulate NF-kappa B by modifying thioredoxin-1 redox-state. SCIENTIFIC REPORTS, v. 6, OCT 4 2016. (12/24677-7, 09/54764-6, 13/08216-2, 13/03520-5, 11/19670-0, 11/03293-3, 13/07937-8)

SARAIVA, ANDRE L.; VERAS, FLAVIO P.; PERES, RAPHAEL S.; TALBOT, JHIMMY; DE LIMA, KALIL A.; LUIZ, JOAO P.; CARBALLIDO, JOSE M.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; RYFFEL, BERNHARD; et al. Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of T(h)17 cells in the lymph nodes. FASEB JOURNAL, v. 32, n. 12, p. 6550-6558, DEC 2018. (13/08216-2, 11/19670-0)

MANCHOPE, MARILIA F.; ARTERO, NAYARA A.; FATTORI, VICTOR; MIZOKAMI, SANDRA S.; PITOL, DIMITRIUS L.; ISSA, JOAO P. M.; FUKADA, SANDRA Y.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; et al. Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NF kappa B. Inflammation Research, v. 67, n. 11-12, p. 997-1012, DEC 2018. (13/08216-2, 11/19670-0)

VIEIRA, SILVIO MANFREDO; SILVA, RANGEL LEAL; LEMOS, HENRIQUE PAULA; DAS NEVES AMORIM, RODRIGO CESAR; COSTA SILVA, ELLEN CRISTINA; REINACH, PETER SOL; CUNHA, FERNANDO QUEIROZ; POHLIT, ADRIAN MARTIN; CUNHA, THIAGO MATTAR. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, v. 95, p. 8-15, JUN 2014. (11/19670-0)

TREVELIN, SILVIA C.; CARLOS, DANIELA; BERETTA, MATTEO; DA SILVA, JOAO S.; CUNHA, FERNANDO Q.. Diabetes Mellitus and Sepsis: A Challenging Association. Shock, v. 47, n. 3, p. 276-287, MAR 2017. (13/08216-2, 11/03293-3, 11/19670-0, 09/54764-6)

YAMACITA-BORIN, FABIANE Y.; ZARPELON, ANA C.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Superoxide anion-induced pain and inflammation depends on TNF alpha/TNFR1 signaling in mice. Neuroscience Letters, v. 605, p. 53-58, SEP 25 2015. (13/08216-2, 11/19670-0)

PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZARPELON, ANA C.; BORGHI, SERGIO M.; STAURENGO-FERRARI, LARISSA; CARVALHO, THACYANA T.; ALVES, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; et al. Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-kappa B and oxidative stress. INFLAMMOPHARMACOLOGY, v. 24, n. 2-3, p. 97-107, JUN 2016. (13/08216-2, 11/19670-0)

PINHO-RIBEIRO, FELIPE A.; ZARPELON, ANA C.; MIZOKAMI, SANDRA S.; BORGHI, SERGIO M.; BORDIGNON, JULIANO; SILVA, RANGEL L.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; et al. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-kappa B activation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 33, p. 8-14, JUL 2016. (13/08216-2, 11/19670-0)

FRANCA, RAFAEL F. O.; COSTA, RENATA S.; SILVA, JAQUELINE R.; PERES, RAPHAEL S.; MENDONCA, LEILA R.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. JOURNAL OF NEUROINFLAMMATION, v. 13, JUN 22 2016. (10/19770-2, 13/08216-2, 11/19670-0)

FATTORI, VICTOR; PINHO-RIBEIRO, FELIPE A.; BORGHI, SERGIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-kappa B activation. Inflammation Research, v. 64, n. 12, p. 993-1003, DEC 2015. (13/08216-2, 11/19670-0)

CALIL, IGOR L.; ZARPELON, ANA C.; GUERRERO, ANA T. G.; ALVES-FILHO, JOSE C.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; VERRI, JR., WALDICEU A.. Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw. PLoS One, v. 9, n. 3, MAR 3 2014. (11/19670-0)

PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 8, p. 2509-2514, FEB 24 2015. (13/08216-2, 11/19670-0)

LOPES, ALEXANDRE H.; TALBOT, JHIMMY; SILVA, RANGEL L.; LIMA, JONILSON B.; FRANCA, RAFAEL O.; VERRI, JR., WALDICEU A.; MASCARENHAS, DANIELLE P.; RYFFEL, BERNHARD; CUNHA, FERNANDO Q.; ZAMBONI, DARIO S.; et al. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain, v. 156, n. 3, p. 451-459, MAR 2015. (13/08216-2, 11/19670-0)

CECILIO, NERRY T.; SOUZA, GUILHERME R.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. The PI3K gamma/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 35, n. 2, p. 364-370, APR 2021. (13/08216-2, 11/19670-0)

SILVA CASTANHEIRA, FERNANDA V. E; BORGES, VANESSA; SONEGO, FABIANE; KANASHIRO, ALEXANDRE; DONATE, PAULA B.; MELO, PAULO H.; PALLAS, KENNETH; RUSSO, REMO C.; AMARAL, FLAVIO A.; TEIXEIRA, MAURO M.; et al. THE ATYPICAL CHEMOKINE RECEPTOR ACKR2 IS PROTECTIVE AGAINST SEPSIS. Shock, v. 49, n. 6, p. 682-689, JUN 2018. (13/08216-2, 11/19670-0)

KANASHIRO, ALEXANDRE; HIROKI, CARLOS HIROJI; DA FONSECA, DENISE MORAIS; BIRBRAIR, ALEXANDER; FERREIRA, RAPHAEL GOMES; BASSI, GABRIEL SHIMIZU; FONSECA, MIRIAN D.; KUSUDA, RICARDO; MARTELOSSI CEBINELLI, GUILHERME CESAR; DA SILVA, KATIUSSIA PINHO; et al. The role of neutrophils in neuro-immune modulation. PHARMACOLOGICAL RESEARCH, v. 151, JAN 2020. (16/08385-7, 13/08216-2, 11/20343-4, 11/19670-0, 12/04237-2)

SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. Science Signaling, v. 11, n. 528, MAY 1 2018. (13/08216-2, 11/19670-0)

TALBOT, JHIMMY; PERES, RAPHAEL S.; PINTO, LARISSA G.; OLIVEIRA, RENE D. R.; LIMA, KALIL A.; DONATE, PAULA B.; SILVA, JAQUELINE R.; RYFFEL, BERNARD; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; et al. Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells. ARTHRITIS RESEARCH & THERAPY, v. 20, JUN 8 2018. (13/08216-2, 11/19670-0)

ZARPELON, ANA C.; FATTORI, VICTOR; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PINHO-RIBEIRO, FELIPE A.; RUIZ-MIYAZAWA, KENJI W.; TURATO, WALTER M.; CUNHA, THIAGO M.; DA COSTA, FERNANDO B.; CUNHA, FERNANDO Q.; et al. The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-kappa B and Cytokines. Inflammation, v. 40, n. 6, p. 2020-2032, DEC 2017. (13/08216-2, 11/19670-0)

FATTORI, VICTOR; HOHMANN, MIRIAM S. N.; ROSSANEIS, ANA C.; MANCHOPE, MARILIA F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; VERRI, JR., WALDICEU A.. Targeting IL-33/ST2 signaling: regulation of immune function and analgesia. EXPERT OPINION ON THERAPEUTIC TARGETS, v. 21, n. 12, p. 1141-1152, 2017. (13/08216-2, 11/19670-0)

SANTA-CECILIA, FLAVIA V.; SOCIAS, BENJAMIN; OUIDJA, MOHAND O.; SEPULVEDA-DIAZ, JULIA E.; ACUNA, LEONARDO; SILVA, RANGEL L.; MICHEL, PATRICK P.; DEL-BEL, ELAINE; CUNHA, THIAGO M.; RAISMAN-VOZARI, RITA. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. NEUROTOXICITY RESEARCH, v. 29, n. 4, p. 447-459, MAY 2016. (13/08216-2, 11/19670-0)

HUANG, LEI; OU, RONG; DE SOUZA, GUILHERME RABELO; CUNHA, THIAGO M.; LEMOS, HENRIQUE; MOHAMED, ESLAM; LI, LINGQIAN; PACHOLCZYK, GABRIELA; RANDALL, JANICE; MUNN, DAVID H.; et al. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLOS PATHOGENS, v. 12, n. 5, MAY 2016. (13/08216-2, 11/19670-0)

BASSI, GABRIEL S.; MALVAR, DAVID DO C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; KANASHIRO, ALEXANDRE. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 389, n. 8, p. 851-861, AUG 2016. (13/08216-2, 12/04237-2, 11/19670-0, 11/20343-4)

FREITAS, CRISTINA S.; ROVEDA, ANTONIO C.; TRUZZI, JR., DANIELA R.; GARCIA, ANDRE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; FRANCO, DOUGLAS W.. Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands. Journal of Medicinal Chemistry, v. 58, n. 11, p. 4439-4448, JUN 11 2015. (12/23651-4, 13/08216-2, 11/19670-0)

BARRAGAN-IGLESIAS, PAULINO; ROCHA-GONZALEZ, HECTOR I.; BARUCH PINEDA-FARIAS, JORGE; MURBARTIAN, JANET; GODINEZ-CHAPARRO, BEATRIZ; REINACH, PETER S.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; GRANADOS-SOTO, VINICIO. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. European Journal of Pharmacology, v. 738, p. 91-100, SEP 5 2014. (11/19670-0)

SONEGO, FABIANE; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Targeting neutrophils in sepsis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, v. 10, n. 8, p. 1019-1028, AUG 2014. (13/08216-2, 11/19670-0)

ALVES-FILHO, JOSE C.; PALSSON-MCDERMOTT, EVA M.. Pyruvate Kinase M2: A Potential Target for Regulating inflammation. FRONTIERS IN IMMUNOLOGY, v. 7, APR 21 2016. (13/08216-2, 11/19670-0)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA VARGAS E SILVA; FERREIRA, RAPHAEL GOMES; KANASHIRO, ALEXANDRE; VITORINO GONCALVES LEITE, CAIO ABNER; NASCIMENTO, DANIELE CARVALHO; COLON, DAVID FERNANDO; BORGES, VANESSA DE FATIMA; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Paradoxical Roles of the neutrophil in Sepsis: Protective and Deleterious. FRONTIERS IN IMMUNOLOGY, v. 7, APR 26 2016. (08/11593-4, 11/19670-0)

SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; TALBOT, JHIMMY; CECILIO, NERRY T.; ROSSATO, MATEUS F.; SILVA, RANGEL L.; SOUZA, GUILHERME R.; SILVA, CASSIA R.; LUCAS, GUILHERME; FONSECA, BENEDITO A.; et al. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. JOURNAL OF NEUROSCIENCE, v. 37, n. 27, p. 6408-6422, JUL 5 2017. (10/12309-8, 13/08216-2, 11/19670-0)

PINEROS ALVAREZ, ANNIE ROCIO; GLOSSON-BYERS, NICOLE; BRANDT, STEPHANIE; WANG, SOUJUAN; WONG, HECTOR; STURGEON, SARAH; MCCARTHY, BRIAN PAUL; TERRITO, PAUL R.; ALVES-FILHO, JOSE CARLOS; HENRIQUE SEREZANI, C.. SOCS1 is a negative regulator of metabolic reprogramming during sepsis. JCI INSIGHT, v. 2, n. 13, JUL 6 2017. (13/08216-2, 11/19670-0)

FRANCA, R. F. O.; VIEIRA, S. M.; TALBOT, J.; PERES, R. S.; PINTO, L. G.; ZAMBONI, D. S.; LOUZADA-JUNIOR, P.; CUNHA, F. Q.; CUNHA, T. M.. Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v. 45, n. 1, p. 8-12, JAN 2 2016. (10/19770-2, 13/08216-2, 11/19670-0)

MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proceedings of the National Academy of Sciences of the United States of America, v. 111, n. 47, p. 16937-16942, NOV 25 2014. (13/08216-2, 11/19670-0)

STAURENGO-FERRARI, LARISSA; TREVELIN, SILVIA C.; FATTORI, VICTOR; NASCIMENTO, DANIELE C.; DE LIMA, KALIL A.; PELAYO, JACINTA S.; FIGUEIREDO, FLORENCIO; CASAGRANDE, RUBIA; FUKADA, SANDRA Y.; TEIXEIRA, MAURO M.; et al. Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-lnduced Septic Arthritis. FRONTIERS IN IMMUNOLOGY, v. 9, MAY 16 2018. (13/08216-2, 11/19670-0)

SANTA-CECILIA, V, FLAVIA; FERREIRA, DAVID W.; GUIMARAES, RAFAELA M.; CECILIO, NERRY T.; FONSECA, MIRIAM M.; LOPES, ALEXANDRE H.; DAVOLI-FERREIRA, MARCELA; KUSUDA, RICARDO; SOUZA, GUILHERME R.; NACHBUR, UELI; et al. The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development. Pain, v. 160, n. 1, p. 102-116, JAN 2019. (13/08216-2, 11/19670-0)

MEDEIROS, PRISCILA; NEGRINI-FERRARI, SYLMARA ESTHER; PALAZZO, ENZA; MAIONE, SABATINO; FERREIRA, SERGIO HENRIQUE; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain. Neurochemical Research, v. 44, n. 9, p. 2068-2080, SEP 2019. (14/11869-0, 12/25167-2, 13/08216-2, 13/12916-0, 11/19670-0, 17/13560-5, 09/17258-5, 14/07902-2)

MEDEIROS, PRISCILA; DOS SANTOS, IEDA REGINA; MATIAS JUNIOR, IVAIR; PALAZZO, ENZA; DA SILVA, JOSE APARECIDO; MACHADO, HELIO RUBENS; FERREIRA, SERGIO HENRIQUE; MAIONE, SABATINO; COIMBRA, NORBERTO CYSNE; DE FREITAS, RENATO LEONARDO. An Adapted Chronic Constriction Injury of the Sciatic Nerve Produces Sensory, Affective, and Cognitive Impairments: A Peripheral Mononeuropathy Model for the Study of Comorbid Neuropsychiatric Disorders Associated with Neuropathic Pain in Rats. PAIN MEDICINE, v. 22, n. 2, p. 338-351, FEB 2021. (11/19670-0, 13/08216-2, 13/12916-0, 17/13560-5, 14/11869-0, 12/25167-2, 14/07902-2, 09/17258-5)

SILVA, CASSIA R.; MELO, BRUNO M. S.; SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; PEREIRA, JANAINA A.; CECILIO, NERRY T.; BERLINK, JONILSON; SOUZA, GIOVANI G.; LUCAS, GUILHERME; VOGL, THOMAS; et al. S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway. BRAIN BEHAVIOR AND IMMUNITY, v. 88, p. 353-362, AUG 2020. (13/08216-2, 11/19670-0)

HIROKI, CARLOS H.; TOLLER-KAWAHISA, JULIANA E.; FUMAGALLI, MARCILIO J.; COLON, DAVID F.; FIGUEIREDO, LUIZ T. M.; FONSECA, BENDITO A. L. D.; FRANCA, RAFAEL F. O.; CUNHA, FERNANDO Q.. Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection. FRONTIERS IN IMMUNOLOGY, v. 10, JAN 31 2020. (13/08216-2, 11/19670-0)

P. MEDEIROS; I.R. DOS SANTOS; A.C. MEDEIROS; J.A. DA SILVA; S.H. FERREIRA; R.L. DE FREITAS; N.C. COIMBRA. Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. Brazilian Journal of Medical and Biological Research, v. 53, n. 5, 2020-04-27. (12/25167-2, 09/17258-5, 17/13560-5, 11/19670-0, 14/07902-2, 14/11869-0, 13/12916-0, 13/08216-2)

FATTORI, VICTOR; SERAFIM, KARLA G. G.; ZARPELON, ANA C.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. Journal of Drug Targeting, v. 25, n. 3, p. 264-274, 2017. (13/08216-2, 11/19670-0)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; CZAIKOSKI, PAULA G.; KANASHIRO, ALEXANDRE; SOUTO, FABRICIO O.; FRANCA, RAFAEL O.; NASCIMENTO, DANIELE C.; FREITAS, ANDRESSA; SPILLER, FERNANDO; CUNHA, LARISSA D.; et al. MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response. PLoS One, v. 9, n. 8, AUG 1 2014. (08/11593-4, 11/19670-0)

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TAMASHIRO, LETICIA FALEIROS; OLIVEIRA, RENE D. R.; OLIVEIRA, RODRIGO; COMINI FROTA, ELIZABETH REGINA; DONADI, EDUARDO ANTONIO; DEL-BEN, CRISTINA MARTA; TEIXEIRA, ANTONIO LUCIO; LOUZADA-JUNIOR, PAULO. Participation of the neutrophin brain-derived neurotrophic factor in neuropsychiatric systemic lupus erythematosus. RHEUMATOLOGY, v. 53, n. 12, p. 2182-2190, DEC 2014. (13/08216-2, 11/19670-0)

VERAS, FLAVIO P.; PERES, RAPHAEL S.; SARAIVA, ANDRE L. L.; PINTO, LARISSA G.; LOUZADA-JUNIOR, PAULO; CUNHA, THIAGO M.; PASCHOAL, JONAS A. R.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. SCIENTIFIC REPORTS, v. 5, OCT 19 2015. (13/08216-2, 09/54014-7, 11/19670-0)

QUADROS, ANDREZA U.; PINTO, LARISSA G.; FONSECA, MIRIAM M.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. SCIENTIFIC REPORTS, v. 5, OCT 29 2015. (13/08216-2, 09/54014-7, 11/19670-0)

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SOUZA, GUILHERME R.; CUNHA, THIAGO M.; SILVA, RANGE L.; LOTUFO, CELINA M.; VERRI, JR., WALDICEU A.; FUNEZ, MANI I.; VILLARREAL, CHRISTIANE F.; TALBOT, JHIMMY; SOUSA, LIRLANDIA P.; PARADA, CARLOS A.; et al. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacology Biochemistry and Behavior, v. 134, p. 49-56, JUL 2015. (13/08216-2, 11/19670-0)

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ZUCOLOTO, AMANDA Z.; MANCHOPE, MARILIA F.; STAURENGO-FERRARI, LARRISA; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; ANTUNES, MAISA M.; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-kappa B activation and cytokine production without antioxidant effects. Inflammation Research, v. 66, n. 7, p. 591-602, JUL 2017. (13/08216-2, 11/19670-0)

LOPES, ALEXANDRE H.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIANCHINI, GIANLUCA; SILVA, RANGEL L.; ZAPERLON, ANA C.; VERRI, JR., WALDICEU A.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; TEIXEIRA, MAURO M.; et al. DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. PHARMACOLOGICAL RESEARCH, v. 103, p. 69-79, JAN 2016. (13/08216-2, 11/19670-0)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; HORTA, CATARINA V.; KANASHIRO, ALEXANDRE; CZAIKOSKI, PAULA G.; ZAMBONI, DARIO S.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.. The host control of a clinical isolate strain of P-aeruginosa infection is independent of Nod-1 but depends on MyD88. Inflammation Research, v. 67, n. 5, p. 435-443, MAY 2018. (08/11593-4, 11/19670-0)

COLON, DAVID F.; WANDERLEY, CARLOS W.; FRANCHIN, MARCELO; SILVA, CAMILA M.; HIROKI, CARLOS H.; CASTANHEIRA, FERNANDA V. S.; DONATE, PAULA B.; LOPES, ALEXANDRE H.; VOLPON, LEILA C.; KAVAGUTI, SILVIA K.; et al. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. CRITICAL CARE, v. 23, APR 8 2019. (13/08216-2, 11/19670-0)

LOURENCO-GONZALEZ, YURI; FATTORI, VICTOR; DOMICIANO, TALITA P.; ROSSANEIS, ANA C.; BORGHI, SERGIO M.; ZANINELLI, TIAGO H.; BERNARDY, CATIA C. F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation, 2019. (13/08216-2, 11/19670-0)

BERTOZZI, MARIANA M.; ROSSANEIS, ANA C.; FATTORI, VICTOR; LONGHI-BALBINOT, DANIELA T.; FREITAS, ANDRESSA; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. Chemico-Biological Interactions, v. 273, p. 180-189, AUG 1 2017. (13/08216-2, 11/19670-0)

FONSECA, MIRIAM D.; CUNHA, FERNANDO Q.; KASHFI, KHOSROW; CUNHA, THIAGO M.. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. PHARMACOLOGY RESEARCH & PERSPECTIVES, v. 3, n. 3, JUN 2015. (13/08216-2, 11/19670-0)

PARRA, ROGERIO S.; LOPES, ALEXANDRE H.; CARREIRA, ELEONORA U.; FEITOSA, MARLEY R.; CUNHA, FERNANDO Q.; GARCIA, SERGIO B.; CUNHA, THIAGO M.; DA ROCHA, JOSE J. R.; FERES, OMAR. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. MEDICAL GAS RESEARCH, v. 5, APR 16 2015. (11/19670-0)

RUIZ-MIYAZAWA, KENJI W.; STAURENGO-FERRARI, LARISSA; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; ANDRADE, KETLEM C.; CLEMENTE-NAPIMOGA, JULIANA T.; ALVES-FILHO, JOSE C.; et al. 15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice. SCIENTIFIC REPORTS, v. 8, SEP 18 2018. (13/08216-2, 10/15014-9, 11/19670-0)

STAURENGO-FERRARI, LARISSA; RUIZ-MIYAZAWA, KENJI W.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; CARVALHO, THACYANA T.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; et al. Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, OCT 2 2018. (13/08216-2, 11/19670-0)

FATTORI, VICTOR; ZARPELON, ANA C.; STAURENGO-FERRARI, LARISSA; BORGHI, SERGIO M.; ZANINELII, TIAGO H.; DA COSTA, FERNANDO B.; AIVES, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; et al. Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model o Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, SEP 25 2018. (13/08216-2, 11/19670-0)

PINTO, LARISSA G.; SOUZA, GUILHERME R.; KUSUDA, RICARDO; LOPES, ALEXANDRE H.; SANT'ANNA, MORENA B.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; CUNHA, THIAGO M.. Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice. Molecular Neurobiology, v. 56, n. 8, p. 5715-5728, AUG 2019. (13/08216-2, 10/04043-8, 11/19670-0)

RUIZ-MIYAZAWA, KENJI W.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; STAURENGO-FERRARI, LARISSA; FATTORI, VICTOR; FERNANDES, GLAURA S. A.; CASELLA, ANTONIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF kappa B and macrophage release of IL-1 beta. Journal of Functional Foods, v. 48, p. 106-116, SEP 2018. (13/08216-2, 11/19670-0, 10/15014-9)

FERREIRA, RAPHAEL G.; RODRIGUES, LILIAN C.; NASCIMENTO, DANIELE C.; KANASHIRO, ALEXANDRE; MELO, PAULO H.; BORGES, VANESSA F.; GOZZI, ALINE; PRADO, DOUGLAS DA SILVA; BORGES, MARCOS C.; RAMALHO, FERNANDO S.; et al. Galectin-3 aggravates experimental polymicrobial sepsis by impairing neutrophil recruitment to the infectious focus. Journal of Infection, v. 77, n. 5, p. 391-397, NOV 2018. (13/08216-2, 11/19670-0)

DAVOLI-FERREIRA, MARCELA; DE LIMA, KALIL A.; FONSECA, MIRIAM M.; GUIMARAES, RAFAELA M.; GOMES, I, FRANCISCO; CAVALLINI, MARIA C.; QUADROS, ANDREZA U.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; et al. Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury. Pain, v. 161, n. 8, p. 1730-1743, AUG 2020. (13/08216-2, 11/19670-0)

GUIMARAESI, RAFAELA M.; DAVOLI-FERREIRA, MARCELA; FONSECA, MIRIAM M.; DAMASCENO, LUIS EDUARDO A.; SANTA-CECILIA, V, FLAVIA; KUSUDA, RICARDO; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.. Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury. Journal of Leukocyte Biology, v. 106, n. 3, SI, p. 541-551, SEP 2019. (13/08216-2, 11/19670-0)

Filed patent(s) as a result of this research project