Role of D6 receptor in the inflammatory response development during sepsis

• Grant number: 12/04132-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date until: June 01, 2012
• End date until: July 31, 2016
• Field of knowledge: Biological Sciences - Pharmacology
• Principal Investigator: Fernando de Queiroz Cunha
• Grantee: Fernanda Vargas e Silva Castanheira
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 11/19670-0 - Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis, AP.TEM
• Associated scholarship(s): 15/21240-5 - Investigation of the mechanisms of D6 expression in vital organs during sepsis, BE.EP.DR

Abstract

Sepsis is a systemic inflammatory response resulted from the inability of the immune system to control infections. Neutrophils are the first cells to arrive at the site of infection, and chemokines have a fundamental role in this process. These chemokines however, contribute to the systemic inflammatory response observed in sepsis. Although under normal physiological conditions, neutrophils do not respond to the CC subfamily of chemokines, our group has shown that during sepsis neutrophils become responsive to these chemokines. In this context, we showed that neutrophils from septic mice express the chemokine receptors, CCR2 and CCR5 which enable neutrophil infiltration in secondary organs and neutrophil migration to the site of infection, respectively. Moreover, others chemokine receptors are being characterized as factors in the activation and/or recruitment of leukocytes. Recently, a new chemokine receptor named D6 has been studied and it has been described as an atypical receptor due to its involvement in the removal and degradation of CC chemokines during several inflammatory conditions. However, to date, there are no studies showing the involvement of D6 receptor in neutrophil migration or sepsis physiopathology. Thus, we aim to investigate the role of this receptor during the development of the local and systemic inflammatory response during sepsis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTANHEIRA, FERNANDA VARGAS E SILVA; DE LIMA, KALIL ALVES; MARTELOSSI CEBINELLI, GUILHERME CESAR; SONEGO, FABIANE; KANASHIRO, ALEXANDRE; COLON, DAVID-FERNANDO; BORGES, VANESSA; CZAIKOSKI, PAULA GISELLE; MOTA, JOSE MAURICIO; CUNHA, THIAGO MATTAR; et al. CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis. Shock, v. 52, n. 5, p. E100-E106, NOV 2019. (13/08216-2, 12/04132-6)

SPILLER, FERNANDO; FORMIGA, RODRIGO OLIVEIRA; DA SILVA COIMBRA, JONATHAN FERNANDES; ALVES-FILHO, JOSE CARLOS; CUNHA, THIAGO MATTAR; CUNHA, FERNANDO QUEIROZ. Targeting nitric oxide as a key modulator of sepsis, arthritis and pain. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 89, p. 32-40, AUG 1 2019. (13/08216-2, 12/04132-6)