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Role of D6 receptor in development and maintenance of chronic neuropathic pain

Grant number: 13/03758-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2013
Effective date (End): September 24, 2017
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal researcher:Thiago Mattar Cunha
Grantee:Andreza Urba de Quadros
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:11/19670-0 - Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis, AP.TEM
Associated scholarship(s):15/00764-6 - Role of complement C5a component in evoked responses at spinal cord neurons in rats with established neuropathic pain, BE.EP.DR


One of the main challenge in pain therapy is the treatment of chronic pain, specially neuropathic pain. The leukocyte migration induced by nerve injury, as well as the release of cytokines and chemokines by these cells, in addition to glial activation, promote awareness of peripheral and central nociceptive systems, leading to perpetuation of pain status. Among the mechanisms that control these factors, the complement component C5a has emerged in the last decade. Although the relevance in neuropathic pain is clear, little is known about the mechanisms by which this broker participates in the genesis and/or maintenance of this condition. Thus, this work aims to promote the expansion of knowledge of the involvement of C5a in chronic neuropathic pain, seeking to clarify its mechanism of action, focusing especially on the description of effects on the peripheral and central nervous system, the spinal level. (AU)

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