Role of D6 receptor in development and maintenance of chronic neuropathic pain

• Grant number: 13/03758-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2013
• End date: September 24, 2017
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Thiago Mattar Cunha
• Grantee: Andreza Urba de Quadros
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 11/19670-0 - Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis, AP.TEM
• Associated scholarship(s): 15/00764-6 - Role of complement C5a component in evoked responses at spinal cord neurons in rats with established neuropathic pain, BE.EP.DR

Abstract

One of the main challenge in pain therapy is the treatment of chronic pain, specially neuropathic pain. The leukocyte migration induced by nerve injury, as well as the release of cytokines and chemokines by these cells, in addition to glial activation, promote awareness of peripheral and central nociceptive systems, leading to perpetuation of pain status. Among the mechanisms that control these factors, the complement component C5a has emerged in the last decade. Although the relevance in neuropathic pain is clear, little is known about the mechanisms by which this broker participates in the genesis and/or maintenance of this condition. Thus, this work aims to promote the expansion of knowledge of the involvement of C5a in chronic neuropathic pain, seeking to clarify its mechanism of action, focusing especially on the description of effects on the peripheral and central nervous system, the spinal level. (AU)