Renal Sensory Activity Regulates the gamma-Aminobutyric Acidergic Inputs to the Paraventricular Nucleus of the Hypothalamus in Goldblatt Hypertension

Autor(es)

Milanez, Maycon I. O. ^[1] ; Veiga, Amanda C. ^[1] ; Martins, Beatriz S. ^[1] ; Pontes, Roberto B. ^[1] ; Bergamaschi, Cassia T. ^[1] ; Campos, Ruy R. ^[1] ; Nishi, Erika E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Cardiovasc Div, Dept Physiol, Escola Paulista Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHYSIOLOGY; v. 11, DEC 15 2020.
• Citações Web of Science: 0

Resumo

Renal sensory activity is centrally integrated within brain nuclei involved in the control of cardiovascular function, suggesting that renal afferents regulate basal and reflex sympathetic vasomotor activity. Evidence has shown that renal deafferentation (DAx) evokes a hypotensive and sympathoinhibitory effect in experimental models of cardiovascular diseases; however, the underlying mechanisms involved in this phenomenon need to be clarified, especially those related to central aspects. We aimed to investigate the role of renal afferents in the control of gamma-aminobutyric acid (GABA)ergic inputs to the paraventricular nucleus (PVN) of the hypothalamus in renovascular hypertensive (2K1C) rats and their influence in the regulation of cardiovascular function. Hypertension was induced by clipping the left renal artery. After 4 weeks, renal DAx was performed by exposing the left renal nerve to a 33 mM capsaicin solution for 15 min. After 2 weeks of DAx, microinjection of muscimol into the PVN was performed in order to evaluate the influence of GABAergic activity in the PVN and its contribution to the control of renal sympathetic nerve activity (rSNA) and blood pressure (BP). Muscimol microinjected into the PVN triggered a higher drop in BP and rSNA in the 2K1C rats and renal DAx mitigated these responses. These results suggest that renal afferents are involved in the GABAergic changes found in the PVN of 2K1C rats. Although the functional significance of this phenomenon needs to be clarified, it is reasonable to speculate that GABAergic alterations occur to mitigate microglia activation-induced sympathoexcitation in the PVN of 2K1C rats. (AU)

• Processo FAPESP: 17/03905-5 - Avaliação da influência da inervação aferente renal na insuficiência renal crônica experimental
• Beneficiário: Amanda Costa Veiga
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 20/02617-9 - Mecanismos envolvidos na reabsorção renal de proteínas na Hipertensão Renovascular: papel do nervo renal
• Beneficiário: Amanda Costa Veiga
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/02671-3 - Ações funcionais e moleculares do nervo renal na doença renal crônica experimental
• Beneficiário: Cassia Marta de Toledo Bergamaschi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/01898-4 - Avaliação das projeções encéfalo-espinais no estabelecimento temporal da hiperativação simpática renal na Hipertensão Renovascular
• Beneficiário: Maycon Igor de Oliveira Milanez
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/11909-3 - Efeitos da denervação renal em um modelo de doença renal crônica
• Beneficiário: Amanda Costa Veiga
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/23809-5 - Regiões encefálicas envolvidas na regulação do sistema cardiovascular ativadas pelas fibras aferentes renais
• Beneficiário: Beatriz Silva Martins
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica