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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Renal Sensory Activity Regulates the gamma-Aminobutyric Acidergic Inputs to the Paraventricular Nucleus of the Hypothalamus in Goldblatt Hypertension

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Milanez, Maycon I. O. [1] ; Veiga, Amanda C. [1] ; Martins, Beatriz S. [1] ; Pontes, Roberto B. [1] ; Bergamaschi, Cassia T. [1] ; Campos, Ruy R. [1] ; Nishi, Erika E. [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Cardiovasc Div, Dept Physiol, Escola Paulista Med, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 11, DEC 15 2020.
Web of Science Citations: 0

Renal sensory activity is centrally integrated within brain nuclei involved in the control of cardiovascular function, suggesting that renal afferents regulate basal and reflex sympathetic vasomotor activity. Evidence has shown that renal deafferentation (DAx) evokes a hypotensive and sympathoinhibitory effect in experimental models of cardiovascular diseases; however, the underlying mechanisms involved in this phenomenon need to be clarified, especially those related to central aspects. We aimed to investigate the role of renal afferents in the control of gamma-aminobutyric acid (GABA)ergic inputs to the paraventricular nucleus (PVN) of the hypothalamus in renovascular hypertensive (2K1C) rats and their influence in the regulation of cardiovascular function. Hypertension was induced by clipping the left renal artery. After 4 weeks, renal DAx was performed by exposing the left renal nerve to a 33 mM capsaicin solution for 15 min. After 2 weeks of DAx, microinjection of muscimol into the PVN was performed in order to evaluate the influence of GABAergic activity in the PVN and its contribution to the control of renal sympathetic nerve activity (rSNA) and blood pressure (BP). Muscimol microinjected into the PVN triggered a higher drop in BP and rSNA in the 2K1C rats and renal DAx mitigated these responses. These results suggest that renal afferents are involved in the GABAergic changes found in the PVN of 2K1C rats. Although the functional significance of this phenomenon needs to be clarified, it is reasonable to speculate that GABAergic alterations occur to mitigate microglia activation-induced sympathoexcitation in the PVN of 2K1C rats. (AU)

FAPESP's process: 17/03905-5 - Evaluation of renal afferent innervation influence in experimental chronic kidney disease
Grantee:Amanda Costa Veiga
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 20/02617-9 - Mechanisms involved in renal protein reabsorption in Renovascular Hypertension: a role for the renal nerve
Grantee:Amanda Costa Veiga
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/02671-3 - Functional and molecular actions of renal nerve in experimental chronic renal failure
Grantee:Cassia Marta de Toledo Bergamaschi
Support type: Regular Research Grants
FAPESP's process: 18/01898-4 - Evaluation of brain-spinal projections in the temporal establishment of renal sympathetic hyperactivation in Renovascular Hypertension
Grantee:Maycon Igor de Oliveira Milanez
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/11909-3 - Effects of renal denervation in a model of chronic kidney disease
Grantee:Amanda Costa Veiga
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/23809-5 - Brain areas involved in the cardiovascular system regulation activated by afferent renal fibers
Grantee:Beatriz Silva Martins
Support type: Scholarships in Brazil - Scientific Initiation