Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue

Autor(es)

Azevedo Macedo, Ana Paula ^[1] ; Ramos da Silva, Adelino Sanchez ^[2] ; Munoz, Vitor Rosetto ^[1] ; Ropelle, Eduardo Rochete ^{[1, 3]} ; Pauli, Jose Rodrigo ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Lab Mol Biol Exercise, UNICAMP, Limeira, SP - Brazil

^[2] Univ Sao Paulo EEFERP USP, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[3] Univ Estadual Campinas, Lab Cell Signaling, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MECHANISMS OF AGEING AND DEVELOPMENT; v. 200, DEC 2021.
• Citações Web of Science: 0

Resumo

Aging is characterized by several physiological changes in the human body, such as the remodeling/redistribution of body fat, highlighted by the increase in fat in the abdominal region due to reduced fat in the peripheral limbs. Abdominal fat is related to metabolic complications and an increased risk for developing diseases such as obesity, type 2 diabetes mellitus, and hypertension. Understanding this process is crucial for developing new therapeutic strategies able to mitigate its impact. This redistribution of fat has been associated with lower activation of brown adipose tissue over the years of life. Brown adipose tissue differs from white adipose tissue, mainly because it produces heat, increasing energy expenditure. Current evidence points to morphological and functional changes in mitochondria during aging, a key mechanism for understanding the dysmetabolic and proinflammatory phenotype associated with senescence. Therefore, this minireview will focus on how aging-induced mitochondrial changes are involved in the remodeling/redistribution of body fat. (AU)

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• Modalidade de apoio: Auxílio à Pesquisa - Regular
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