Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue

Author(s)

Azevedo Macedo, Ana Paula ^[1] ; Ramos da Silva, Adelino Sanchez ^[2] ; Munoz, Vitor Rosetto ^[1] ; Ropelle, Eduardo Rochete ^{[1, 3]} ; Pauli, Jose Rodrigo ^{[1, 3]}

Affiliation

^[1] Univ Estadual Campinas, Lab Mol Biol Exercise, UNICAMP, Limeira, SP - Brazil

^[2] Univ Sao Paulo EEFERP USP, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[3] Univ Estadual Campinas, Lab Cell Signaling, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil

• Document type: Journal article
• Source: MECHANISMS OF AGEING AND DEVELOPMENT; v. 200, DEC 2021.
• Web of Science Citations: 0

Abstract

Aging is characterized by several physiological changes in the human body, such as the remodeling/redistribution of body fat, highlighted by the increase in fat in the abdominal region due to reduced fat in the peripheral limbs. Abdominal fat is related to metabolic complications and an increased risk for developing diseases such as obesity, type 2 diabetes mellitus, and hypertension. Understanding this process is crucial for developing new therapeutic strategies able to mitigate its impact. This redistribution of fat has been associated with lower activation of brown adipose tissue over the years of life. Brown adipose tissue differs from white adipose tissue, mainly because it produces heat, increasing energy expenditure. Current evidence points to morphological and functional changes in mitochondria during aging, a key mechanism for understanding the dysmetabolic and proinflammatory phenotype associated with senescence. Therefore, this minireview will focus on how aging-induced mitochondrial changes are involved in the remodeling/redistribution of body fat. (AU)

• FAPESP's process: 20/08192-0 - Autophagy responses in the hypothalamus of obese mice submitted to intermittent fasting associated with physical training
• Grantee: Adelino Sanchez Ramos da Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/13443-1 - Implications of aerobic exercise on the Notch 1 signaling pathway and regulation of lipogenesis and gluconeogenesis in the liver
• Grantee: José Rodrigo Pauli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/21709-4 - Implications of mitonuclear imbalance and UPRmt in hypothalamic neurons in the genesis of Obesity
• Grantee: Eduardo Rochete Ropelle
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/11820-5 - Nr1d1 function on the aging-associated Sarcopenia
• Grantee: Adelino Sanchez Ramos da Silva
• Support Opportunities: Research Projects - Thematic Grants