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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Brazilian berries prevent colitis induced in obese mice by reducing the clinical signs and intestinal damage

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Autor(es):
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do Nascimento, Roberto de Paula [1] ; Polezi, Gabriele [1] ; Rizzato, Julia Soto [1] ; Batista, Patricia Berilli [1] ; dos Santos, Nathalia Medina [1] ; Loubet Filho, Paulo Sergio [1] ; Reguengo, Livia Mateus [1] ; Morari, Joseane [2] ; Junior, Stanislau Bogusz [3] ; Ribeiro Paiotti, Ana Paula [4] ; Pereira, Jose Aires [5] ; Real Martinez, Carlos Augusto [5] ; Velloso, Licio Augusto [2] ; Betim Cazarin, Cinthia Bau [6] ; Marostica Junior, Mario Roberto [1]
Número total de Autores: 15
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Sch Food Engn FEA, Lab Nutr & Metab LANUM, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Chem Sao Carlos IQSC, Sao Carlos Campus, Sao Carlos, SP - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Lab Hepatol Mol Appl Discipline Gastroenterol, Lab Mol & Expt Pathol, Sao Paulo Campus, Sao Paulo - Brazil
[5] Sao Francisco Univ USF, Postgrad Program Hlth Sci, Braganca Paulista Campus, Braganca Paulista, SP - Brazil
[6] Univ Campinas UNICAMP, Sch Food Engn FEA, Prot Resources Lab LAFOP, Campinas, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: FOOD BIOSCIENCE; v. 44, n. B DEC 2021.
Citações Web of Science: 0
Resumo

This study hypothesized that polyphenol- and fiber-rich Brazilian fruits could elicit preventive effects in inflammatory bowel diseases (IBDs), even when applied to obese subjects. Therefore, the purpose was to investigate the implications of the consumption of acai pulp and jaboticaba peel on obese mice with dextran sodium sulfate (DSS)-induced colitis. First, obesity was induced by a high-fat diet for 13 weeks, followed by the inclusion of DSS in the water for five days. Animals received during the whole experiment a standard or high-fat diet, with the last one containing or not 5% (w/w) freeze-dried acai or jaboticaba. The diets added with the fruits had a higher content in total phenolic compounds (1.1 mg GAE/g) and an increased antioxidant capacity (up to 25.32 mu mol TE/g). The high-fat diet promoted weight gain starting from the eighth week of the experiment. While jaboticaba delayed and reduced body weight gain, acai highly exacerbated it, also increasing the accumulation of fats. Colitis was successfully induced as seen by the clinical signs and damaged colonic mucosa. The high-fat diets did not increase the severity of colitis in comparison with the standard regimen, despite promoting additional weight gain. Animals that received acai or jaboticaba did not have many symptoms of colitis and showed a grand recovery in colonic histological parameters. Additionally, acai increased the expression of tight-junction-related molecules. Despite being included in a high-fat diet, the fruits still managed to promote healing effects in colitis, therefore indicating their potential for trials with IBD patients. (AU)

Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
Beneficiário:Glaucia Maria Pastore
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/13320-9 - Efeito do azeite da polpa e do chá das folhas do abacate da variedade Hass associado à atividade física no tratamento da obesidade induzida por dieta hiperlipídica
Beneficiário:Mário Roberto Maróstica Junior
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/11069-5 - Ação de berries brasileiras sobre parâmetros metabólicos e desempenho cognitivo de animais obesos
Beneficiário:Mário Roberto Maróstica Junior
Modalidade de apoio: Auxílio à Pesquisa - Regular