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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Brazilian berries prevent colitis induced in obese mice by reducing the clinical signs and intestinal damage

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Author(s):
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do Nascimento, Roberto de Paula [1] ; Polezi, Gabriele [1] ; Rizzato, Julia Soto [1] ; Batista, Patricia Berilli [1] ; dos Santos, Nathalia Medina [1] ; Loubet Filho, Paulo Sergio [1] ; Reguengo, Livia Mateus [1] ; Morari, Joseane [2] ; Junior, Stanislau Bogusz [3] ; Ribeiro Paiotti, Ana Paula [4] ; Pereira, Jose Aires [5] ; Real Martinez, Carlos Augusto [5] ; Velloso, Licio Augusto [2] ; Betim Cazarin, Cinthia Bau [6] ; Marostica Junior, Mario Roberto [1]
Total Authors: 15
Affiliation:
[1] Univ Campinas UNICAMP, Sch Food Engn FEA, Lab Nutr & Metab LANUM, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Chem Sao Carlos IQSC, Sao Carlos Campus, Sao Carlos, SP - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Lab Hepatol Mol Appl Discipline Gastroenterol, Lab Mol & Expt Pathol, Sao Paulo Campus, Sao Paulo - Brazil
[5] Sao Francisco Univ USF, Postgrad Program Hlth Sci, Braganca Paulista Campus, Braganca Paulista, SP - Brazil
[6] Univ Campinas UNICAMP, Sch Food Engn FEA, Prot Resources Lab LAFOP, Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: FOOD BIOSCIENCE; v. 44, n. B DEC 2021.
Web of Science Citations: 0
Abstract

This study hypothesized that polyphenol- and fiber-rich Brazilian fruits could elicit preventive effects in inflammatory bowel diseases (IBDs), even when applied to obese subjects. Therefore, the purpose was to investigate the implications of the consumption of acai pulp and jaboticaba peel on obese mice with dextran sodium sulfate (DSS)-induced colitis. First, obesity was induced by a high-fat diet for 13 weeks, followed by the inclusion of DSS in the water for five days. Animals received during the whole experiment a standard or high-fat diet, with the last one containing or not 5% (w/w) freeze-dried acai or jaboticaba. The diets added with the fruits had a higher content in total phenolic compounds (1.1 mg GAE/g) and an increased antioxidant capacity (up to 25.32 mu mol TE/g). The high-fat diet promoted weight gain starting from the eighth week of the experiment. While jaboticaba delayed and reduced body weight gain, acai highly exacerbated it, also increasing the accumulation of fats. Colitis was successfully induced as seen by the clinical signs and damaged colonic mucosa. The high-fat diets did not increase the severity of colitis in comparison with the standard regimen, despite promoting additional weight gain. Animals that received acai or jaboticaba did not have many symptoms of colitis and showed a grand recovery in colonic histological parameters. Additionally, acai increased the expression of tight-junction-related molecules. Despite being included in a high-fat diet, the fruits still managed to promote healing effects in colitis, therefore indicating their potential for trials with IBD patients. (AU)

FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants