Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet

• Grant number: 15/13320-9
• Support type: Regular Research Grants
• Duration: March 01, 2016 - February 28, 2018
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal researcher: Mário Roberto Maróstica Junior
• Grantee: Mário Roberto Maróstica Junior
• Home Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Associated with a large number of diseases, obesity is directly related to the development of metabolic and endocrine disorders that have severe consequences such as peripheral insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease. Seventy-one species of medicinal plants are used in the Brazilian public health system, due to cultural and traditional use for the treatment of diseases related to obesity. The avocado is a sheet of such medicinal plants that contain bioactive compounds, such as flavonoids, which are able to decrease the inflammatory subclinical obesity in order to improve the action of insulin in type 2 diabetes. The avocado pulp oil despite now marketed in the XXI century, already has records of positive effects on human health with the potential to reduce the effects of Non-alcoholic fatty liver disease, because it contains carotenoids, phytosterols and monounsaturated fatty acid in quantity higher than that of olive oil. Not only bioactive compounds from plants and oils are important in the treatment of obesity and its comorbidities. A balanced diet associated with physical activity potentiate the beneficial effects on metabolic recovery and help promote weight reduction, improvement of the inflammatory and oxidative improves insulin action and glucose uptake, and is the initial treatment for Non-alcoholic fatty liver disease. Within this scope, this paper aims to evaluate the effect of oil pulp, leaf tea of avocado Hass variety and physical activity in obesity and subclinical inflammation of male Wistar rats fed high-fat diet from weaning to adulthood. (AU)

Scientific publications

(23)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TARONE, ADRIANA GADIOLI; SILVA, ERIC KEVEN; BETIM CAZARIN, CINTHIA BAU; MAROSTICA JUNIOR, JR., MARIO ROBERTO. Inulin/fructooligosaccharides/pectin-based structured systems: Promising encapsulating matrices of polyphenols recovered from jabuticaba peel. FOOD HYDROCOLLOIDS, v. 111, FEB 2021. (15/13320-9, 15/50333-1)

BUSCH FURLAN, CIBELE PRISCILA; VALLE, SANDRA COSTA; OSTMAN, ELIN; MAROSTICA, JR., MARIO ROBERTO; TOVAR, JUSCELINO. Inclusion of Hass avocado-oil improves postprandial metabolic responses to a hypercaloric-hyperlipidic meal in overweight subjects. Journal of Functional Foods, v. 38, n. A, p. 349-354, NOV 2017. (15/13320-9)

ALEXANDRINO, THAIS DOLFINI; TOMAZINI MUNHOZ MOYA, AMANDA MARIA; MADUREIRA DE MEDEIROS, TIAGO DANIEL; MORARI, JOSEANE; VELLOSO, LICIO AUGUSTO; LEAL, RAQUEL FRANCO; MAROSTICA, MARIO ROBERTO; PASTORE, GLAUCIA MARIA; BETIM CAZARIN, CINTHIA BAU; BICAS, JULIANO LEMOS. Anti-inflammatory effects of monoterpenoids in rats with TNBS-induced colitis. PHARMANUTRITION, v. 14, DEC 2020. (16/21619-7, 15/50333-1, 15/13320-9, 18/11069-5)

DO NASCIMENTO, ROBERTO DE PAULA; POLEZI, GABRIELE; RIZZATO, JULIA SOTO; BATISTA, PATRICIA BERILLI; DOS SANTOS, NATHALIA MEDINA; LOUBET FILHO, PAULO SERGIO; REGUENGO, LIVIA MATEUS; MORARI, JOSEANE; JUNIOR, STANISLAU BOGUSZ; RIBEIRO PAIOTTI, ANA PAULA; et al. Brazilian berries prevent colitis induced in obese mice by reducing the clinical signs and intestinal damage. FOOD BIOSCIENCE, v. 44, n. B, DEC 2021. (15/50333-1, 15/13320-9, 18/11069-5)

FUENTES, EDUARDO; TROSTCHANSKY, ANDRES; REGUENGO, LIVIA M.; JUNIOR, MARIO R. M.; PALOMO, IVAN. Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace. CURRENT DRUG TARGETS, v. 22, n. 15, p. 1716-1724, 2021. (18/11069-5, 15/50333-1, 15/13320-9)

SANZANA, SIGRID; RODRIGUEZ, LYANNE; BARRAZA BARRIONUEVO, HAYLEEN; ALBORNOZ POBLETE, CESAR; MAROSTICA JUNIOR, MARIO ROBERTO; FUENTES, EDUARDO; PALOMO, IVAN. ntiplatelet Activity of Cucurbita maxim. JOURNAL OF MEDICINAL FOOD, AUG 2021. (15/13320-9, 18/11069-5, 15/50333-1)

MACHADO, ANA PAULA DA FONSECA; DO NASCIMENTO, ROBERTO DE PAULA; ALVES, MARIANA DA ROCHA; REGUENGO, LIVIA MATEUS; MAROSTICA JUNIOR, MARIO ROBERTO. razilian tucuma-do-Amazonas (Astrocaryum aculeatum) and tucuma-do-Para (Astrocaryum vulgare) fruits: bioactive composition, health benefits, and technological potentia. Food Research International, v. 151, JAN 2022. (18/11069-5, 19/25048-2, 19/03228-9, 17/23657-6, 15/50333-1, 15/13320-9)

DE PAULA DO NASCIMENTO, ROBERTO; DA FONSECA MACHADO, ANA PAULA; LIMA, VERENA SILVA; TOMAZINI MUNHOZ MOYA, AMANDA MARIA; REGUENGO, LIVIA MATEUS; BOGUSZ JUNIOR, STANISLAU; LEAL, RAQUEL FRANCO; CAO-NGOC, PHU; ROSSI, JEAN CHRISTOPHE; LECLERCQ, LAURENT; et al. Chemoprevention with a tea from hawthorn (Crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress. FOOD CHEMISTRY-X, v. 12, DEC 30 2021. (15/50333-1, 15/13320-9, 18/11069-5, 17/23657-6)

KIDO, LARISSA AKEMI; HAHM, EUN-RYEONG; KIM, SU-HYEONG; BASEGGIO, ANDRESSA MARA; CAGNON, VALERIA HELENA ALVES; SINGH, SHIVENDRA V.; MAROSTICA, JR., MARIO ROBERTO. Prevention of Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Mice by Yellow Passion Fruit Extract and Antiproliferative Effects of Its Bioactive Compound Piceatannol. JOURNAL OF CANCER PREVENTION, v. 25, n. 2, p. 87-99, JUN 2020. (18/11069-5, 18/09793-7, 15/50333-1, 15/13320-9)

ARRUDA, HENRIQUE SILVANO; NERI-NUMA, IRAMAIA ANGELICA; KIDO, LARISSA AKEMI; MAROSTICA JUNIOR, MARIO ROBERTO; PASTORE, GLAUCIA MARIA. Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases. Journal of Functional Foods, v. 75, DEC 2020. (18/11069-5, 15/13320-9, 17/01573-5, 15/50333-1)

DO NASCIMENTO, ROBERTO DE PAULA; REGUENGO, LIVIA MATEUS; DA FONSECA MACHADO, ANA PAULA; MAROSTICA JUNIOR, MARIO ROBERTO. he preventive and therapeutic potential of native Brazilian fruits on colorectal cance. FOOD BIOSCIENCE, v. 46, APR 2022. (18/11069-5, 19/03228-9, 17/23657-6, 15/50333-1, 19/25048-2, 15/13320-9)

VALLE, MARIA C. P. R.; VIEIRA, ISABEL A.; FINO, LUCIANA C.; GALLINA, DARLILA A.; ESTEVES, ANDREA M.; DA CUNHA, DIOGO T.; CABRAL, LUCELIA; BENATTI, FABIANA B.; MAROSTICA JUNIOR, MARIO R.; BATISTA, ANGELA G.; et al. Immune status, well-being and gut microbiota in military supplemented with synbiotic ice cream and submitted to field training: a randomised clinical trial. BRITISH JOURNAL OF NUTRITION, v. 126, n. 12, p. 1794-1808, DEC 28 2021. (18/18366-5, 15/50333-1, 17/25007-9, 18/11069-5, 15/13320-9)

ARRUDA, HENRIQUE SILVANO; SILVA, ERIC KEVEN; PEIXOTO ARAUJO, NAYARA MACEDO; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO. Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems. Molecules, v. 26, n. 9, MAY 2021. (19/27103-0, 19/13465-8, 18/11069-5, 18/10608-0, 15/13320-9, 15/50333-1)

AGUIAR, LAIS MARINHO; BICAS, JULIANO LEMOS; FUENTES, EDUARDO; ALARCON, MARCELO; GONZALEZ, IVAN PALOMO; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO; CAZARIN, CINTHIA BAU BETIM. Non-nutrients and nutrients from Latin American fruits for the prevention of cardiovascular diseases. Food Research International, v. 139, JAN 2021. (18/11069-5, 15/50333-1, 15/13320-9)

TARONE, ADRIANA GADIOLI; SILVA, ERIC KEVEN; BARROS, HELENA DIAS DE FREITAS QUEIROZ; CAZARIN, CINTHIA BAU BETIM; JUNIOR, MARIO ROBERTO MAROSTICA. High-intensity ultrasound-assisted recovery of anthocyanins from jabuticaba by-products using green solvents: Effects of ultrasound intensity and solvent composition on the extraction of phenolic compounds. Food Research International, v. 140, FEB 2021. (15/13320-9, 15/50333-1)

PECANHA, JULIANA DE SOUZA; DOS SANTOS, NATHALIA MEDINA; MAROSTICA JUNIOR, MARIO ROBERTO; MICHELETTI, ANA CAMILA; LIAO, LUCIANO MORAIS; ALCANTARA, GLAUCIA BRAZ. NMR-based metabolomics of dried berries in comparison with dietary supplements. Journal of Pharmaceutical and Biomedical Analysis, v. 209, FEB 5 2022. (15/13320-9, 18/11069-5, 19/13465-8, 15/50333-1)

BASEGGIO, ANDRESSA MARA; KIDO, LARISSA AKEMI; VIGANO, JULIANE; CARNEIRO, MARA JUNQUEIRA; LAMAS, CELINA DE ALMEIDA; MARTINEZ, JULIAN; SAWAYA, ALEXANDRA CHRISTINE HELENA FRANKLAND; CAGNON, VALERIA HELENA ALVES; MAROSTICA JUNIOR, MARIO ROBERTO. Systemic antioxidant and anti-inflammatory effects of yellow passion fruit bagasse extract during prostate cancer progression. JOURNAL OF FOOD BIOCHEMISTRY, AUG 2021. (17/01573-5, 18/11069-5, 15/13320-9, 15/50333-1, 19/13465-8)

GERALDI, MARINA VILAR; BETIM CAZARIN, CINTHIA BAU; DIAS-AUDIBERT, FLAVIA LUISA; PEREIRA, GUSTAVO ARAUJO; CARVALHO, GABRIELA GUIMARAES; KABUKI, DIRCE YORIKA; CATHARINO, RODRIGO RAMOS; PASTORE, GLAUCIA MARIA; BEHRENS, JORGE HERMAN; CRISTIANINI, MARCELO; et al. Influence of high isostatic pressure and thermal pasteurization on chemical composition, color, antioxidant properties and sensory evaluation of jabuticaba juice. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 139, MAR 2021. (15/13320-9, 19/12244-8, 18/11069-5, 15/50333-1)

SOUZA, ALANN THAFFARELL PORTILHO; FREITAS, GILEADE PEREIRA; LOPES, HELENA BACHA; TOTOLI, GABRIELA GUARALDO CAMPOS; TARONE, ADRIANA GADIOLI; MAROSTICA-JUNIOR, MARIO ROBERTO; ROSA, ADALBERTO LUIZ; BELOTI, MARCIO MATEUS. Jabuticaba peel extract modulates adipocyte and osteoblast differentiation of MSCs from healthy and osteoporotic rats. JOURNAL OF BONE AND MINERAL METABOLISM, v. 39, n. 2, SEP 2020. (15/13320-9, 17/20349-9, 18/11069-5, 15/50333-1, 17/12622-7)

DO NASCIMENTO, ROBERTO DE PAULA; MOYA, AMANDA MARIA TOMAZINI MUNHOZ; MACHADO, ANA PAULA DA FONSECA; GERALDI, MARINA VILAR; DIEZ-ECHAVE, PATRICIA; VEZZA, TERESA; GALVEZ, JULIO; CAZARIN, CINTHIA BAIL BETIM; MAROSTICA, JR., MARIO ROBERTO. Review on the potential application of non-phenolic compounds from native Latin American food byproducts in inflammatory bowel diseases. Food Research International, v. 139, JAN 2021. (15/50333-1, 15/13320-9, 19/12244-8, 17/23657-6, 18/11069-5)

LAIBER PASCOAL, GABRIELA DE FREITAS; DE ALMEIDA SOUSA CRUZ, MARTA ANGELA; DE ABREU, JOEL PIMENTEL; BARROS SANTOS, MILLENA CRISTINA; FANARO, GUSTAVO BERNARDES; MAROSTICA JUNIOR, MARIO ROBERTO; SILVA, OTNIEL FREITAS; ALVES MOREIRA, RICARDO FELIPE; CAMERON, LUIZ CLAUDIO; LARRAZ FERREIRA, MARIANA SIMOES; et al. Evaluation of the antioxidant capacity, volatile composition and phenolic content of hybrid Vitis vinifera L. varieties sweet sapphire and sweet surprise. Food Chemistry, v. 366, JAN 1 2022. (19/13465-8, 18/11069-5, 15/50333-1, 15/13320-9)

REGUENGO, LIVIA MATEUS; SALGACO, MATEUS KAWATA; SIVIERI, KATIA; MAROSTICA JUNIOR, MARIO ROBERTO. gro-industrial by-products: Valuable sources of bioactive compound. Food Research International, v. 152, FEB 2022. (15/50333-1, 19/25048-2, 18/11069-5, 15/13320-9)

BARROS MARIUTTI, LILIAN REGINA; REBELO, KEMILLA SARMENTO; BISCONSIN-JUNIOR, ANTONIO; DE MORAIS, JANNE SANTOS; MAGNANI, MARCIANE; MALDONADE, IRIANI RODRIGUES; MADEIRA, NUNO RODRIGO; TIENGO, ANDREA; MAROSTICA, JR., MARIO ROBERTO; BETIM CAZARIN, CINTHIA BAU. The use of alternative food sources to improve health and guarantee access and food intake. Food Research International, v. 149, NOV 2021. (19/13465-8, 18/11069-5, 15/50333-1, 15/13320-9)