A new look at the role of nitric oxide in preeclampsia: Protein S-nitrosylation

Autor(es)

Nunes, Priscila Rezeck ; Pinheiro, Lucas Cezar ; Martins, Laisla Zanetoni ; Dias-Junior, Carlos Alan ; Palei, Ana Carolina Taveiros ; Sandrim, Valeria Cristina

• Tipo de documento: Artigo Científico
• Fonte: PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH; v. 29, p. 7-pg., 2022-08-01.

Resumo

The formation of S-nitrosothiols (SNOs) occurs with the reaction of nitric oxide (NO) and free thiol groups in proteins. This process, called S-nitrosylation, allows NO to interfere with or even modulate a variety of cellular functions, culminating with the modification of protein trafficking, redox state, and cell cycle. Furthermore, NO plays a role in modulating a wide range of functions in endothelial cells specifically, including inflammation, apoptosis, permeability, migration, and cell growth. As such, NO acts as a mediator in several physiological processes. The interaction between endothelial nitric oxide synthase (eNOS) and proteins that are to be targeted for S-nitrosylation is a key determinant of the specificity of NO signaling. Deficits in the bioavailability of NO have been associated with pregnancy-related disorders, such as preeclampsia (PE). The study of S-nitrosylation in PE, as well as the identification of targeted proteins, may contribute to a better understanding of its pathophysiology and the development of drugs for the treatment of PE patients. In this review, we aimed to present the mechanism of S-nitrosylation, the regulatory pathways, and some proteins by which S-nitrosylation can modulate NO availability with a potential impact on PE. (AU)

• Processo FAPESP: 20/14610-9 - Avaliação da inibição farmacológica e molecular do inflamassoma NLRP3 e suas consequências em modelo in vitro de Pré-Eclâmpsia
• Beneficiário: Priscila Rezeck Nunes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/07570-8 - Nitrosilação proteica: um mecanismo crítico e alvo farmacológico na sepse grave
• Beneficiário: Lucas Cezar Pinheiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/24484-0 - Caracterização farmacológica do sulfeto de hidrogênio (H2S) derivado do tecido adiposo perivascular (PVAT) na hipertensão gestacional em ratas
• Beneficiário: Carlos Alan Candido Dias Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/07230-8 - Arginase em pré-eclâmpsia: estudo de polimorfismos genéticos, fatores circulantes e ensaios in vitro
• Beneficiário: Valeria Cristina Sandrim
• Modalidade de apoio: Auxílio à Pesquisa - Regular