A new look at the role of nitric oxide in preeclampsia: Protein S-nitrosylation

Author(s)

Nunes, Priscila Rezeck ; Pinheiro, Lucas Cezar ; Martins, Laisla Zanetoni ; Dias-Junior, Carlos Alan ; Palei, Ana Carolina Taveiros ; Sandrim, Valeria Cristina

• Document type: Journal article
• Source: PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH; v. 29, p. 7-pg., 2022-08-01.

Abstract

The formation of S-nitrosothiols (SNOs) occurs with the reaction of nitric oxide (NO) and free thiol groups in proteins. This process, called S-nitrosylation, allows NO to interfere with or even modulate a variety of cellular functions, culminating with the modification of protein trafficking, redox state, and cell cycle. Furthermore, NO plays a role in modulating a wide range of functions in endothelial cells specifically, including inflammation, apoptosis, permeability, migration, and cell growth. As such, NO acts as a mediator in several physiological processes. The interaction between endothelial nitric oxide synthase (eNOS) and proteins that are to be targeted for S-nitrosylation is a key determinant of the specificity of NO signaling. Deficits in the bioavailability of NO have been associated with pregnancy-related disorders, such as preeclampsia (PE). The study of S-nitrosylation in PE, as well as the identification of targeted proteins, may contribute to a better understanding of its pathophysiology and the development of drugs for the treatment of PE patients. In this review, we aimed to present the mechanism of S-nitrosylation, the regulatory pathways, and some proteins by which S-nitrosylation can modulate NO availability with a potential impact on PE. (AU)

• FAPESP's process: 20/14610-9 - Evaluation of pharmacological and molecular inhibition of NLRP3 inflammasome and its consequences in an in vitro model of Preeclampsia
• Grantee: Priscila Rezeck Nunes
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/07570-8 - Proteic nitrosylation: a critical mechanism and pharmacological target in severe sepsis
• Grantee: Lucas Cezar Pinheiro
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/24484-0 - Pharmacological characterization of perivascular adipose tissue (PVAT)-derived hydrogen sulphide (H2S) in gestational hypertension in rats
• Grantee: Carlos Alan Candido Dias Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/07230-8 - Arginase in preeclampsia: study of genetic polymorphism, circulating factors and in vitro assays
• Grantee: Valeria Cristina Sandrim
• Support Opportunities: Regular Research Grants