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Effects of pectins on colorectal cancer: targeting hallmarks as a support for future clinical trials

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Autor(es):
Donadio, Janaina L. S. ; Ramos do Prado, Samira Bernardino ; Rogero, Marcelo M. ; Fabi, Joao Paulo
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: FOOD & FUNCTION; v. 13, n. 22, p. 17-pg., 2022-10-21.
Resumo

The intake of dietary fibers has been associated with a reduction in the risk of colorectal cancer. Pectins - a class of dietary fibers - are polysaccharides that have a complex structure with a wide range of direct and indirect biological beneficial effects on humans. Direct effects include dilution of carcinogens, reduction in cholesterol levels, and interaction with immune cells. Indirect effects include the fermentation and production of short-chain fatty acids. All these biological effects have implications for colon cancer development; however, the exact mechanisms are not fully understood. In this review, we explore the clinical trials regarding dietary fibers and colorectal cancer, thus indicating the potential anti-cancer effects of pectins and modified pectins. We focused on the emerging biological effects of pectins through targeting colorectal cancer hallmark effects and the enabling characteristics. We provide an overview of the mechanisms for each hallmark capability and how the different pectins might exert that anti-cancer effect, such as induction of apoptosis, reduction in cancer cell proliferation and metastasis. The data compilation described herein can guide future clinical trials to investigate how to target specific pectin structures to act as an adjuvant in colon cancer treatment. (AU)

Processo FAPESP: 19/11816-8 - Efeito das fibras alimentares modificadas de mamões papaia em co-cultura tridimensional de células humanas de câncer de cólon e em modelo in vivo de ratos com carcinogênese de cólon quimicamente induzida
Beneficiário:Joao Paulo Fabi
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/18794-0 - Efeito das fibras alimentares do mamão papaia em modelo de co-cultura 3D de células de Câncer de Cólon e em modelo in vivo de ratos com Carcinogênese de Cólon quimicamente induzida
Beneficiário:Janaina Lombello Santos Donadio
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos
Beneficiário:Bernadette Dora Gombossy de Melo Franco
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 12/23970-2 - Alterações biológicas das pectinas de mamão com possíveis benefícios à saúde humana
Beneficiário:Joao Paulo Fabi
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores