MicroRNAs in thyroid development, function and tumorigenesis

Autor(es)

Fuziwara, Cesar Seigi ; Kimura, Edna Teruko

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Endocrinology; v. 456, n. C, p. 7-pg., 2017-11-15.

Resumo

MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that modulate the vast majority of cellular processes. During development, the correct timing and expression of miRNAs in the tissue differentiation is essential for organogenesis and functionality. In thyroid gland, DICER and miRNAs are necessary for accurately establishing thyroid follicles and hormone synthesis. Moreover, DICER1 mutations and miRNA deregulation observed in human goiter influence thyroid tumorigenesis. The thyroid malignant transformation by MAPK oncogenes is accompanied by global miRNA changes, with a marked reduction of "tumor-suppressor" miRNAs and activation of oncogenic miRNAs. toss of thyroid cell differentiation/function, and consequently iodine trapping impairment, is an important clinical characteristic of radioiodine-refractory thyroid cancer. However, few studies have addressed the direct role of miRNAs in thyroid gland physiology. Here, we focus on what we have learned in the thyroid follicular cell differentiation and function as revealed by cell and animal models and miRNA modulation in thyroid tumorigenesis. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 16/17129-4 - Influência da superfamíia de TGFbeta e de RNAs regulatórios na via MAPK na tumorigênese da tiroide
• Beneficiário: Edna Teruko Kimura
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50521-0 - Regulação transcricional do microRNA miR-17-92 no câncer de tiroide agressivo
• Beneficiário: Cesar Seigi Fuziwara
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/11019-4 - Papel da nova família de proteínas tumor-específicas FAM83 no câncer de tiróide
• Beneficiário: Edna Teruko Kimura
• Modalidade de apoio: Auxílio à Pesquisa - Regular