| Texto completo | |
| Autor(es): |
Pessoa, Erika V. M.
;
Moura, Marcio H. C.
;
Rodrigues, Larissa
;
Rossi e Silva, Rafaela
;
Castro, Erique
;
Festuccia, William T.
;
Donado-Pestana, Carlos M.
;
Genovese, Maria Ines
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FOOD PRODUCTION PROCESSING AND NUTRITION; v. 6, n. 1, p. 9-pg., 2024-08-04. |
| Resumo | |
Skeletal muscle responds for most of the insulin-stimulated glucose disposal at postprandial state, impacting glucose homeostasis. Polyphenols were shown to prevent obesity-associated glucose intolerance and peripheral insulin resistance in animal models, but the implication of skeletal muscle to these effects is unclear. We investigated the role of polyphenolic extracts from jaboticaba (Plinia jaboticaba (Vell.) Berg) (PEJ), a Brazilian native species, on skeletal muscle insulin resistance in diet-induced obese mice. PEJ administration was associated with an increase in skeletal muscle protein content of glucose transporter-4 (GLUT-4) and AMP-activated protein kinase (AMPK) phosphorylated at Thr172. PEJ also reduced skeletal muscle mRNA levels of inflammatory genes nuclear factor-kappa B (NF-kappa B), tumoral necrose factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and c-Jun N-terminal kinase (JNK). This study demonstrates that polyphenols from jaboticaba may be a valuable therapeutic agent in the management and prevention of obesity-associated metabolic disorders by reducing skeletal muscle obesity-associated insulin resistance and inflammation. (AU) | |
| Processo FAPESP: | 21/09237-0 - Metabolismo pós-prandial e inflamação: o papel dos ácidos biliares como moléculas de sinalização |
| Beneficiário: | Larissa Rodrigues |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 20/16542-0 - Relação entre inflamação e metabolismo primário no período pós-prandial |
| Beneficiário: | Carlos Mario Donado Pestana |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos |
| Beneficiário: | Bernadette Dora Gombossy de Melo Franco |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |