Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)): a review

Autor(es)

Silva, Isis T. ^[1] ; Mello, Ana P. Q. ^[1] ; Damasceno, Nagila R. T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: LIPIDS IN HEALTH AND DISEASE; v. 10, SEP 28 2011.
• Citações Web of Science: 40

Resumo

The association of cardiovascular events with Lp-PLA(2) has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lysophospholipids, compounds that have a pro-inflammatory function. Therefore, the evaluation of the distribution of Lp-PLA(2) in the lipid fractions emphasized the dual role of the enzyme in the inflammatory process, since the HDL-Lp-PLA(2) enzyme contributes to the reduction of atherosclerosis, while LDL-Lp-PLA(2) stimulates this process. Recently, it has been verified that diet components and drugs can influence the enzyme activity and concentration. Thus, the effects of these treatments on Lp-PLA(2) may represent a new kind of prevention of cardiovascular disease. Therefore, the association of the enzyme with the traditional assessment of cardiovascular risk may help to predict more accurately these diseases. (AU)

• Processo FAPESP: 07/52123-8 - Papel dos lipídeos e antioxidantes dietéticos nas propriedades oxidativas e inflamatórias da paf-ah em adolescentes obesos
• Beneficiário: Isis Tande da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/51664-5 - Papel dos lipídeos e antioxidantes dietéticos nas propriedades oxidativas e inflamatórias da PAF-AH em adolescentes
• Beneficiário: Elizabeth Aparecida Ferraz da Silva Torres
• Modalidade de apoio: Auxílio à Pesquisa - Regular