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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)): a review

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Author(s):
Silva, Isis T. [1] ; Mello, Ana P. Q. [1] ; Damasceno, Nagila R. T. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: LIPIDS IN HEALTH AND DISEASE; v. 10, SEP 28 2011.
Web of Science Citations: 40
Abstract

The association of cardiovascular events with Lp-PLA(2) has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lysophospholipids, compounds that have a pro-inflammatory function. Therefore, the evaluation of the distribution of Lp-PLA(2) in the lipid fractions emphasized the dual role of the enzyme in the inflammatory process, since the HDL-Lp-PLA(2) enzyme contributes to the reduction of atherosclerosis, while LDL-Lp-PLA(2) stimulates this process. Recently, it has been verified that diet components and drugs can influence the enzyme activity and concentration. Thus, the effects of these treatments on Lp-PLA(2) may represent a new kind of prevention of cardiovascular disease. Therefore, the association of the enzyme with the traditional assessment of cardiovascular risk may help to predict more accurately these diseases. (AU)