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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Case Report: Occurrence of Paracoccidioides lutzii in the Amazon Region: Description of Two Cases

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Autor(es):
Marques-da-Silva, Silvia Helena [1] ; Rodrigues, Anderson Messias [2, 3] ; Sybren de Hoog, G. [3] ; Silveira-Gomes, Fabiola [4] ; de Camargo, Zoilo Pires [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Inst Evandro Chagas IEC SVS MS, Lab Micol, BR-67030000 Ananindeua, Para - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Microbiol Imunol & Parasitol, Sao Paulo - Brazil
[3] CBS KNAW Fungal Biodivers Ctr, Utrecht - Netherlands
[4] Fed Univ Para, Inst Ciencias Biol, BR-66059 Belem, Para - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: American Journal of Tropical Medicine and Hygiene; v. 87, n. 4, p. 710-714, OCT 2012.
Citações Web of Science: 25
Resumo

Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin America, is known to be caused by at least four different phylogenetic lineages within the Paracoccidioides brasiliensis complex, including S1, PS2, PS3, and Pb01-like group. Herein, we describe two cases of PCM in patients native from the Amazon region. The disease was originally thought to have been caused by P. brasiliensis. Despite the severity of the cases, sera from the patients were negative in immunodiffusion tests using the standard exoantigen from P. brasiliensis B-339. However, a positive response was recorded with an autologous preparation of Paracoccidioides lutzii exoantigen. A phylogenetic approach based on the gp43 and ARF loci revealed high similarity between our clinical isolates and the Pb01-like group. The occurrence of PCM caused by P. lutzii in the Brazilian Amazon (Para State) was thus proven. The incidence of PCM caused by P. lutzii may be underestimated in northern Brazil. (AU)

Processo FAPESP: 09/54024-2 - Biologia molecular e proteômica de fungos de interesse médico: Paracoccidioides brasiliensis e Sporothrix schenckii
Beneficiário:Zoilo Pires de Camargo
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 11/07350-1 - Biologia do complexo Sporothrix schenckii: Análise de marcadores moleculares e proteômicos e o papel de moléculas antigênicas e antifúngicas na esporotricose
Beneficiário:Anderson Messias Rodrigues
Linha de fomento: Bolsas no Brasil - Doutorado