Case Report: Occurrence of Paracoccidioides lutzii in the Amazon Region: Description of Two Cases

Autor(es)

Marques-da-Silva, Silvia Helena ^[1] ; Rodrigues, Anderson Messias ^{[2, 3]} ; Sybren de Hoog, G. ^[3] ; Silveira-Gomes, Fabiola ^[4] ; de Camargo, Zoilo Pires ^[2]

Afiliação do(s) autor(es)

^[1] Inst Evandro Chagas IEC SVS MS, Lab Micol, BR-67030000 Ananindeua, Para - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Microbiol Imunol & Parasitol, Sao Paulo - Brazil

^[3] CBS KNAW Fungal Biodivers Ctr, Utrecht - Netherlands

^[4] Fed Univ Para, Inst Ciencias Biol, BR-66059 Belem, Para - Brazil

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Tropical Medicine and Hygiene; v. 87, n. 4, p. 710-714, OCT 2012.
• Citações Web of Science: 25

Resumo

Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin America, is known to be caused by at least four different phylogenetic lineages within the Paracoccidioides brasiliensis complex, including S1, PS2, PS3, and Pb01-like group. Herein, we describe two cases of PCM in patients native from the Amazon region. The disease was originally thought to have been caused by P. brasiliensis. Despite the severity of the cases, sera from the patients were negative in immunodiffusion tests using the standard exoantigen from P. brasiliensis B-339. However, a positive response was recorded with an autologous preparation of Paracoccidioides lutzii exoantigen. A phylogenetic approach based on the gp43 and ARF loci revealed high similarity between our clinical isolates and the Pb01-like group. The occurrence of PCM caused by P. lutzii in the Brazilian Amazon (Para State) was thus proven. The incidence of PCM caused by P. lutzii may be underestimated in northern Brazil. (AU)

• Processo FAPESP: 09/54024-2 - Biologia molecular e proteômica de fungos de interesse médico: Paracoccidioides brasiliensis e Sporothrix schenckii
• Beneficiário: Zoilo Pires de Camargo
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/07350-1 - Biologia do complexo Sporothrix schenckii: Análise de marcadores moleculares e proteômicos e o papel de moléculas antigênicas e antifúngicas na esporotricose
• Beneficiário: Anderson Messias Rodrigues
• Linha de fomento: Bolsas no Brasil - Doutorado