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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Case Report: Occurrence of Paracoccidioides lutzii in the Amazon Region: Description of Two Cases

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Marques-da-Silva, Silvia Helena [1] ; Rodrigues, Anderson Messias [2, 3] ; Sybren de Hoog, G. [3] ; Silveira-Gomes, Fabiola [4] ; de Camargo, Zoilo Pires [2]
Total Authors: 5
[1] Inst Evandro Chagas IEC SVS MS, Lab Micol, BR-67030000 Ananindeua, Para - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Microbiol Imunol & Parasitol, Sao Paulo - Brazil
[3] CBS KNAW Fungal Biodivers Ctr, Utrecht - Netherlands
[4] Fed Univ Para, Inst Ciencias Biol, BR-66059 Belem, Para - Brazil
Total Affiliations: 4
Document type: Journal article
Source: American Journal of Tropical Medicine and Hygiene; v. 87, n. 4, p. 710-714, OCT 2012.
Web of Science Citations: 25

Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin America, is known to be caused by at least four different phylogenetic lineages within the Paracoccidioides brasiliensis complex, including S1, PS2, PS3, and Pb01-like group. Herein, we describe two cases of PCM in patients native from the Amazon region. The disease was originally thought to have been caused by P. brasiliensis. Despite the severity of the cases, sera from the patients were negative in immunodiffusion tests using the standard exoantigen from P. brasiliensis B-339. However, a positive response was recorded with an autologous preparation of Paracoccidioides lutzii exoantigen. A phylogenetic approach based on the gp43 and ARF loci revealed high similarity between our clinical isolates and the Pb01-like group. The occurrence of PCM caused by P. lutzii in the Brazilian Amazon (Para State) was thus proven. The incidence of PCM caused by P. lutzii may be underestimated in northern Brazil. (AU)

FAPESP's process: 09/54024-2 - Molecular biology and proteomics of medically interesting fungi: Paracoccidioides brasiliensis and Sporothrix schenckii
Grantee:Zoilo Pires de Camargo
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/07350-1 - Biology of Sporothrix schenckii complex: Analysis of molecular and proteomics markers, and the role of antigenic and antifungal molecules in sporotrichosis
Grantee:Anderson Messias Rodrigues
Support type: Scholarships in Brazil - Doctorate