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Identification of secondary metabolites in Harpagophytum procumbens extracts that inhibit cyclooxygenases 1/2 and 5 - lipoxygenase expression and/or activities

Grant number: 17/50293-5
Support type:Regular Research Grants
Duration: May 01, 2018 - April 30, 2019
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Cooperation agreement: University of Missouri
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal researcher:Fernando Batista da Costa
Grantee:Fernando Batista da Costa
Principal researcher abroad: William Folk
Institution abroad: University of Missouri, Columbia (UM), United States
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The proposed project explores a botanical, Harpagophytum procumbens subsp. procumbens (Burch.) DC. Ex Meisn, family Pedaliaceae (Devil's Claw; Garra do Diabo) for which there is evidence of benefit to human health, namely its use in management of inflammatory arthritis, lower back pain and other musculoskeletal conditions. H. procumbens is one of the most frequently used herbal products for these conditions in Europe, and also is widely used in Africa, the United States and Brazil (and other countries). Recent studies support its potential utility, however the variability in the products being marketed and lack of well-defined mechanisms and biological targets impede medical acceptance. (AU)

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