Pacing in cycling: a study about the neuromuscular fatigue and metabolic interface

• Grant number: 17/22053-0
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2018 - April 30, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Rômulo Cássio de Moraes Bertuzzi
• Grantee: Rômulo Cássio de Moraes Bertuzzi
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Adriano Eduardo Lima da Silva ; Daniel Boari Coelho

Abstract

More recent studies have suggested that power output distribution along a race adopted in endurance sports, defined as pacing, is able to influence the athletic performance. It is believed that pacing reflects the metabolic alterations produced in exercised muscles, which has a feedback sent to central nervous system by afferent nervous, resulting in an alteration in neural drive. It has been proposed that the alteration in neural drive occurs in order to maintain an overall physiological steady state and avoid the development of the neuromuscular fatigue. Although previous studies have provided relevant insights about main factors related to pacing, it is important to note that these suggestions remained speculative. These studies have not determined the relationship between pacing and the contributions of central and peripheral mechanisms for the development of the neuromuscular fatigue. In addition, it is also important to highlight that the overall physiological steady state in endurance exercise has been determined only in workload constant tests and using a small number of metabolites (~10 metabolites). Therefore, the main objective of this proposal will be to analyze the contributions of central and peripheral mechanisms for the development of the neuromuscular fatigue, as well as their relationship with metabolic profile determined in the different phases of pacing during a 4-km cycling time-trial (4-km TT). Based on previous studies suggesting that the neuromuscular fatigue during short-duration exercise (3-5 min) is mainly determined by peripheral processes and that the metabolic profile is maintained stable during endurance exercise, it is hypothesized that: i) there will be a higher contribution of peripheral fatigue at the first phases of the 4-km TT, while at the last phase there will be a higher contribution of central fatigue, ii) there will be an overall physiological steady state during 4-km TT with metabolic profile being composed mainly by metabolites related to aerobic metabolism. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BIGLIASSI, MARCELO; BERTUZZI, ROMULO. Exploring the Use of Meditation as a Valuable Tool to Counteract Sedentariness. FRONTIERS IN PSYCHOLOGY, v. 11, FEB 25 2020. (17/22053-0, 18/08898-0)

AZEVEDO, RAFAEL DE ALMEIDA; CRUZ, RAMON; COUTO, PATRICIA; SILVA-CAVALCANTE, MARCOS DAVID; BOARI, DANIEL; LIMA-SILVA, ADRIAN E.; MILLET, GUILLAUME Y.; BERTUZZI, ROMULO. Characterization of performance fatigability during a self-paced exercise. Journal of Applied Physiology, v. 127, n. 3, p. 838-846, SEP 2019. (17/22053-0)

AZEVEDO, RAFAEL A.; MILIONI, FABIO; MURIAS, JUAN M.; BERTUZZI, ROMULO; MILLET, GUILLAUME Y.. Dynamic Changes of Performance Fatigability and Muscular O-2 Saturation in a 4-km Cycling Time Trial. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 53, n. 3, p. 613-623, MAR 2021. (16/26281-4, 16/02683-6, 17/22053-0)

BIGLIASSI, MARCELO; GALANO, BRUNO M.; LIMA-SILVA, ADRIANO E.; BERTUZZI, ROMULO. Effects of mindfulness on psychological and psychophysiological responses during self-paced walking. PSYCHOPHYSIOLOGY, v. 57, n. 4, JAN 2020. (17/22053-0, 18/08898-0)

AZEVEDO, RAFAEL DE ALMEIDA; SILVA-CAVALCANTE, MARCOS DAVID; LIMA-SILVA, ADRIANO EDUARDO; BERTUZZI, ROMULO. Fatigue development and perceived response during self-paced endurance exercise: state-of-the-art review. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 121, n. 3, JAN 2021. (17/22053-0)

BIGLIASSI, MARCELO; OCUBARO, ALESSANDRO M.; LIMA-SILVA, ADRIANO E.; BUZZACHERA, COSME F.; BERTUZZI, ROMULO. Psychological and psychophysiological mechanisms underlying the effects of meditation during moderate-intensity exercise. INTERNATIONAL JOURNAL OF SPORT AND EXERCISE PSYCHOLOGY, v. 20, n. 3, p. 29-pg., 2022-01-01. (17/22053-0, 18/08898-0)

AZEVEDO, RAFAEL DE ALMEIDA; SILVA-CAVALCANTE, MARCOS DAVID; CRUZ, RAMON; COUTO, PATRICIA; LIMA-SILVA, ADRIANO E.; BERTUZZI, ROMULO. Distinct pacing profiles result in similar perceptual responses and neuromuscular fatigue development: Why different ``roads{''} finish at the same line?. European Journal of Sport Science, MAY 2021. (17/22053-0)

AZEVEDO, RAFAEL DE ALMEIDA; CRUZ, RAMON; HASEGAWA, JULIO SATOSHI; GASPARI, ARTHUR FERNANDES; TRAINA CHACON-MIKAHIL, MARA PATRICIA; SILVA-CAVALCANTE, MARCOS DAVID; COELHO, DANIEL BOARI; LIMA-SILVA, ADRIANO E.; BERTUZZI, ROMULO. Effects of induced local ischemia during a 4-km cycling time trial on neuromuscular fatigue development. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 320, n. 6, p. R812-R823, JUN 2021. (17/22053-0)

BERTUZZI, ROMULO; SILVA-CAVALCANTE, MARCOS D.; COUTO, PATRICIA GUIMARAES; AZEVEDO, RAFAEL DE ALMEIDA; COELHO, DANIEL BOARI; ZAGATTO, ALESSANDRO; LIMA-SILVA, ADRIANO EDUARDO; MILLET, GUILLAUME Y.. Prior Upper Body Exercise Impairs 4-km Cycling Time-Trial Performance Without Altering Neuromuscular Function. RESEARCH QUARTERLY FOR EXERCISE AND SPORT, v. 92, n. 1, FEB 2020. (17/22053-0)

AZEVEDO, RAFAEL DE ALMEIDA; SILVA-CAVALCANTE, MARCOS DAVID; CRUZ, RAMON; COUTO, PATRICIA; LIMA-SILVA, ADRIANO E.; BERTUZZI, ROMULO. Distinct pacing profiles result in similar perceptual responses and neuromuscular fatigue development: Why different "roads" finish at the same line?. European Journal of Sport Science, v. 22, n. 7, p. 11-pg., 2021-05-28. (17/22053-0)

AZEVEDO, R. DE ALMEIDA; CRUZ, R.; COUTO, P.; SILVA-CAVALCANTE, M. D.; BOARI, D.; OKUNO, N.; LIMA-SILVA, A. E.; BERTUZZI, R.. Effects of prior high-intensity endurance exercise in subsequent 4-km cycling time trial performance and fatigue development. SCIENCE & SPORTS, v. 37, n. 1, p. 11-pg., 2022-02-01. (17/22053-0)