Fatigue process during supramaximal effort: Analysis of central and peripherical mechanisms, muscular acidosis, energetic substrate, enzymatic activity and metabolic

• Grant number: 18/21126-6
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2019
• End date: January 31, 2022
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Alessandro Moura Zagatto
• Grantee: Alessandro Moura Zagatto
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated researchers: DANIEL ALEXANDRE BOULLOSA ÁLVAREZ ; Fabio Milioni

Abstract

The main purpose of research project will be investigate the mechanisms engaged in fatigue during supramaximal effort in cycling, as well as if these mechanisms are altered with exercise training (i.e.. high-intensity interval training). Therefore, will be used the twitch interpolation technical to measure the central e peripheral fatigue, neuromuscular responses with electromyography response and isometric force, muscle biopsies before and immediately after the exhaustion for analyzing of muscle buffering capacity, muscular pH and enzymatic and metabolic responses, as well as verify the effect of high intensity interval training in these parameters. To answer the main question of project will be performed 2 independent studies, both with minimal 10 participants. The study A will be conducted with muscle biopsies before and after exercise to verify the main metabolics engaged in the fatigue using the metabolomic technical, while the study B will focus in responses of training on rate of use substrate content (muscle biopsy in resting before and after the training) and central and pheripherical fatigue. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZAGATTO, ALESSANDRO M.; BISHOP, DAVID J.; ANTUNES, BARBARA MOURA; BECK, WLADIMIR R.; MALTA, ELVIS S.; DE POLI, RODRIGO A. B.; CAVAGLIERI, CLAUDIA R.; CHACON-MIKAHIL, MARA PATRICIA T.; CASTRO, ALEX. Impacts of high-intensity exercise on the metabolomics profile of human skeletal muscle tissue. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 32, n. 2, NOV 2021. (20/13939-7, 17/21724-8, 19/25282-5, 18/21126-6)

ZAGATTO, ALESSANDRO M.; BISHOP, DAVID J.; ANTUNES, BARBARA MOURA; BECK, WLADIMIR R.; MALTA, ELVIS S.; DE POLI, RODRIGO A. R.; CAVAGLIERI, CLAUDIA R.; CHACON-MIKAHIL, MARA PATRICIA T.; CASTRO, ALEX. Impacts Of Severe Intensity Domain Exercise On The Metabolomics Profile Of Human Muscle Tissue. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 53, n. 8, p. 2-pg., 2021-08-01. (18/21126-6)

BONETTI DE POLI, RODRIGO ARAUJO; FIALHO LOPES, VITHOR HUGO; LIRA, FABIO SANTOS; ZAGATTO, ALESSANDRO MOURA; JIMENEZ-MALDONADO, ALBERTO; ANTUNES, BARBARA MOURA. Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women. SCIENTIFIC REPORTS, v. 11, n. 1, FEB 18 2021. (19/22726-0, 19/17445-1, 19/25282-5, 18/21126-6)

STOUTH, DEREK W.; VANLIESHOUT, TIFFANY L.; WEBB, ERIN K.; LJUBICIC, VLADIMIR. Deletion Of CARM1 In Skeletal Muscle Attenuates Fasting-induced Atrophy. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 53, n. 8, p. 1-pg., 2021-08-01. (18/21126-6)

DALTON, BENJAMIN E.; VANDUSSELDORP, TRISHA A.; KIANI, KAVEH; HA, PHUONG L.; OLMOS, ALEX A.; BAILLY, ALYSSA R.; BRYANTSEV, ANTON; HESTER, GARRETT M.. Effect Of Age On High-velocity Power And Myofiber Morphology And Composition. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 53, n. 8, p. 1-pg., 2021-08-01. (18/21126-6)