Research Grants 17/26439-0 - Neurobiologia, Comunicação celular - BV FAPESP
Advanced search
Start date
Betweenand

An interdisciplnary approach on the role of gap junctions and miRNAs in the development and degeneration of the nervous system

Abstract

The complexity of the nervous system is related not only to the activity of individual neurons but to the communication patterns established between them. In addition to well-known chemical synapses, signaling in the nervous system occurs by direct coupling between cells via gap junctions (GJs) channels. These channels allow the passage of molecules up to 1 KDa and are formed by protein subunits called connexins (Cx). An unexplored possibility of cellular communication is the exchange of genetic material between cells. Recent reports in the literature have described that some classes of ncRNAs could mediate this communication, such as circular RNA (cRNA) and miRNAs, molecules that could be transferred by exosomes, or even via plasma, cerebrospinal fluid or colostrum. Another mechanism of communication in the nervous system would be the passage of miRNAs by JCs. In this context, we are interested in determining aspects related to the role of miRNAs in the development and degeneration of the nervous system, including i) changes caused by specific miRNAs target molecules; ii) control of the synthesis and stability / degradation of ncRNAs. In this project, we will use molecular and cellular biology techniques, as well as electrophysiological recordings. This project represents the continuity and evolution of the studies started with the support of FAPESP through Young Researcher and Regular Research Grants. It is important to highlight that the proposed methodologies are employed by our group, especially those related to our internships in research or technological development institutions such as University of Florida (2011), Plexon Neurotechnology (2011) and Cold Spring Harbor (2012). This project is supported by Dr. Jean X. Jiang (Harvard University / University of Texas Health Science Center), Dr. Thomas De Marse and Dr. Brandi Ormerod (University of Florida at Gainesville), Sten Rüdiger (Humboldt University) and of groups based at the University of São Paulo, UFMG and INPE, as well as postdocs, undergraduate and graduate students engaged with this proposal. Finally, it is important to note that the support given to this project will serve several research groups of our institution, since UFABC's research laboratories are multi-user facilities. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AYRES FERRAZ, MARIANA SACRINI; KIHARA, ALEXANDRE HIROAKI. Hurst entropy: A method to determine predictability in a binary series based on a fractal-related process. Physical Review E, v. 99, n. 6, . (17/26439-0, 15/50122-0)
PASCHON, VERA; CORREIA, FELIPE FERNANDES; MORENA, BEATRIZ CINTRA; DA SILVA, VICTOR ALLISSON; DOS SANTOS, GUSTAVO BISPO; DA SILVA, MARIA CRISTINA CARLAN; CRISTANTE, ALEXANDRE FOGACA; WILLERTH, STEPHANIE MICHELLE; PERRIN, FLORENCE EVELYNE; KIHARA, ALEXANDRE HIROAKI. CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury. Molecular Neurobiology, v. 57, n. 4, p. 2085-2100, . (17/26439-0)
BORGES, F. S.; PROTACHEVICZ, P. R.; PENA, R. F. O.; LAMEU, E. L.; HIGA, V, G. S.; KIHARA, J. A. H.; MATIAS, F. S.; ANTONOPOULOS, C. G.; DE PASQUALE, R.; ROQUE, A. C.; et al. Self-sustained activity of low firing rate in balanced networks. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, v. 537, . (16/23398-8, 13/07699-0, 15/50122-0, 17/18977-1, 15/07311-7, 11/19296-1, 17/13502-5, 17/20920-8, 17/26439-0, 13/25667-8)
PASCHON, VERA; MORENA, BEATRIZ CINTRA; CORREIA, FELIPE FERNANDES; BELTRAME, GIOVANNA ROSSI; DOS SANTOS, GUSTAVO BISPO; CRISTANTE, ALEXANDRE FOGACA; KIHARA, ALEXANDRE HIROAKI. VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury. SCIENTIFIC REPORTS, v. 9, . (17/26439-0)
VASQUEZ MATSUDA, VICTOR DANIEL; BUSTELO TEJADA, MARTIN; MOTTA-TEIXEIRA, LIVIA CLEMENTE; IKEBARA, JULIANE MIDORI; CARDOSO, DEBORA STERZECK; MACHADO-NILS, ALINE VILAR; LEE, VITOR YONAMINE; DICCINI, ISABELLE; ARRUDA, BRUNA PETRUCELLI; MARTINS, PAMELA PINHEIRO; et al. Impact of neonatal anoxia and hypothermic treatment on development and memory of rats. Experimental Neurology, v. 340, . (17/26439-0, 18/14072-7, 18/06731-0, 15/18415-8, 16/18941-4)
AYRES FERRAZ, MARIANA SACRINI; KIHARA, ALEXANDRE HIROAKI. Hurst entropy: A method to determine predictability in a binary series based on a fractal-related process. PHYSICAL REVIEW E, v. 99, n. 6, p. 6-pg., . (17/26439-0, 15/50122-0)
KAEHNE, MALTE; RUEDIGER, STEN; KIHARA, ALEXANDRE HIROAKI; LINDNER, BENJAMIN. Gap junctions set the speed and nucleation rate of stage I retinal waves. PLOS COMPUTATIONAL BIOLOGY, v. 15, n. 4, . (17/26439-0, 15/50122-0)
RAEISOSSADATI, REZA; MOVIO, MARILIA INES; WALTER, LAIS TAKATA; TAKADA, SILVIA HONDA; DEL DEBBIO, CAROLINA BELTRAME; KIHARA, ALEXANDRE HIROAKI. Small Molecule GSK-J1 Affects Differentiation of Specific Neuronal Subtypes in Developing Rat Retina. Molecular Neurobiology, v. 56, n. 3, p. 1972-1983, . (17/26439-0, 13/07458-2, 14/16711-6, 15/04495-0)
ROYERO, PEDRO XAVIER; VILAR HIGA, GUILHERME SHIGUETO; KOSTECKI, DAIANE SOARES; DOS SANTOS, BIANCA ARAUJO; ALMEIDA, CAYO; ANDRADE, KEZIA ACCIOLY; KINJO, ERIKA REIME; KIHARA, ALEXANDRE HIROAKI. Ryanodine receptors drive neuronal loss and regulate synaptic proteins during epileptogenesis. Experimental Neurology, v. 327, . (17/26439-0)

Please report errors in scientific publications list using this form.
X

Report errors in this page


Error details: