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Inflammatory and Epigenetic Markers of Prognosis of Patients with Sepsis After Hospital Discharge.

Grant number: 17/13715-9
Support type:Regular Research Grants
Duration: June 01, 2018 - May 31, 2020
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Marcel Cerqueira Cesar Machado
Grantee:Marcel Cerqueira Cesar Machado
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers: Antonio Carlos Nogueira ; Francisco Garcia Soriano ; Rodrigo Cerqueira Borges ; Rui Curi

Abstract

Post-septic patients, after hospital discharge, present high mortality rate, reaching 30% after one year, 70% after two years, and 81.9% after five years. High incidence of causes of post-septic patient death and prognostic markers, after hospital discharge, remain unknown and require investigation. There is a close relationship between plasma levels of C-reactive protein (CRP) - and therefore the inflammatory state - and mortality after hospital discharge in post-septic patients. Macrophages are one of the main effector cells of innate immunity. These cells exhibit receptors that bind to pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPS), which trigger the inflammatory response. After PAMP or DAMP binding, there is activation of inflammatory pathways, and of the NLRP3 inflammasome. In patients with sepsis, exacerbated activation of these mechanisms impairs acute inflammatory resolution, leading to systemic inflammation state. MicroRNAs (miRNAs) are non-coding and small RNAs that act as post-transcriptional regulators of gene expression. Alterated expressions of these molecules have been associated with various diseases. MiRNAs have been suggested to be potential prognostic biomarkers in septic patients. Patients exhibit modified expression of the following miRNAs in the acute phase of sepsis: miR-15a, -16, -122, -193 and -483-5p, -297, -574-5p, -34a, -27a, -130a, -155, -150, -146a, -223 and -499-5p. Little is known however about the miRNA profile after hospital discharge in post-septic patients. The aim of this study is to identify inflammatory and epigenetic markers of prognosis of post-septic patients after hospital discharge. Plasma concentrations of cytokines (pro- and anti-inflammatory), exossomal miRNA profile, and monocyte activation state will be evaluated in patients that presented severe sepsis after hospital discharge. These patients will be evaluated at different periods: during the septic period, at the time of hospital discharge and 3, 6, and 12 months afterwards. Predictive plasma markers of septic patients with survival prognosis after hospital discharge will be established, contributing for a more accurate treatment and reduced mortality rate. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (39 total):
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News Medical (Austrália): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Health Medicine Network (EUA): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Technology Alpha: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
HealthMedicinentral: Sepsis can cause alterations in the functioning of defense cells that lead to death | HealthMedicinentral (12/May/2021)
Hekim.pro Doctor (Azerbaijão): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
SOHU.com (China): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Best Allergy Medicine HQ: Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Eminetra Today (EUA): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Eminetra Today (EUA): Sepsis causes changes in the function of defense cells and can lead to death (12/May/2021)
The Uncover Reality (Índia): Cell Reprogramming in Sepsis Patients Helps Explain Deterioration of Health Even After hospital Discharge (Medicine) (12/May/2021)
Globe Health News: Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
News O Time (Estados Unidos): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
New.qq.com (China): 败血症会导致防御细胞功能的改变,从而导致死亡 - Sepse pode causar alterações na função das células de defesa, levando à morte (12/May/2021)
Detonic: Sensation discusses why clients that endure blood poisoning pass away quicker after medical facility discharge (12/May/2021)
Inter Reviewed: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Infinity CS News: Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Jkwshk.tv (China): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Plexusmd.com: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Medical Xpress (Reino Unido): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Bioengineer (Reino Unido): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Science Codex: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Scienmag Science Magazine (Reino Unido): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
InfoSurHoy (EUA): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
7thSpace: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Hekim.pro Doctor (Azerbaijão): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Health910: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Burada Biliyorum (Turquia): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Freeschi: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Loire-net.tv (EUA): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
News O Time (Estados Unidos): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
LaptrinhX: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Biotech Asia News (Índia): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
MediExpose (ìndia): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
4State News: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
The Health News Express: Phenomenon explains why sufferers who survive sepsis die sooner after hospital discharge (11/May/2021)
Патологоанатом Padolski (Ucrânia): Почему пациенты, пережившие сепсис, имеют все шансы умереть раньше, чем им было «уготовано» до этого (11/May/2021)
Vaccar.biz: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
invesBrain (Canadá): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Zephyrnet.com (Espanha): El fenómeno explica por qué los pacientes que sobreviven a la sepsis mueren antes del alta hospitalaria (11/May/2021)