| Grant number: | 18/05485-6 |
| Support Opportunities: | Regular Research Grants |
| Start date: | July 01, 2018 |
| End date: | March 31, 2021 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Maria Isabel Cardoso Alonso-Vale |
| Grantee: | Maria Isabel Cardoso Alonso-Vale |
| Host Institution: | Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil |
| Associated researchers: | Luciana Chagas Caperuto ; Monica Marques Telles |
Abstract
Our research group has been investigating the role of fatty acids (FAs) as bioactive substance in white adipose tissue (WAT), particularly the palmitoleic acid (of the omega-7 class) and fish oil (FO) rich in É-3 polyunsaturated FAs. The present study proposes a therapeutic approach with these FAs in mice submitted to obesity induced by a high fat diet in order to understand a possible role in the direction of mesenchymal cells derived from adipose tissue [MSCs or adipose tissue-derived stromal cells (ADSC)] contained in the stromal vascular (SV) cell fraction of WAT, such as proliferation, differentiation and browning. Using a model of obesity, we aim to acquire more subsidies for the understanding of the mechanisms related to the obesity development, assuming a hypothesis that these FAs modulate a "healthy" expansion of the WAT. This hypothesis is based on: a) our previous studies showing beneficial effects of fish oil (such as reduction of the adipose mass and improvement of insulin sensitivity) and palmitoleic acid (such as increased mitochondrial function and futile cycle TAG/FA cycle) on adipocyte metabolism; b) data from the literature indicating that É-3 FAs are PPAR agonists able to regulating body weight and adiposity, adipogenesis and continuous remodeling of WAT, regardless of dietary intake; c) data from the literature showing that palmitoleic acid improves the plasma lipid profile in obese and diabetic patients, glucose tolerance and insulin sensitivity and recent studies describing a relevant anti-inflammatory effect of palmitoleic acid on macrophage derived from bone marrow, J774 macrophages and intraperitoneal macrophages; d) the demonstration of browning in subcutaneous white adipose deposits (under certain stimulus) and the identification that these inducers of browning could decrease the obesity and related diseases; e) the demonstration that recruitment of new adipocytes by adipogenesis stimulation results in a healthy expansion of WAT and inhibits hypertrophic obesity (or pathological expansion of WAT). Taken together, we postulate that these FAs can function as important agents for preventing or treating obesity and correlated diseases. (AU)
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