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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Melatonin Supplementation Attenuates the Pro-Inflammatory Adipokines Expression in Visceral Fat from Obese Mice Induced by A High-Fat Diet

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Mendes de Farias, Talita da Silva [1] ; da Paixao, Regislane Ino [1] ; Cruz, Maysa Mariana [1] ; Cavalcante da Cunha de Sa, Roberta Dourado [1] ; Simao, Jussara de Jesus [1] ; Antraco, Vitor Jaco [1] ; Cardoso Alonso-Vale, Maria Isabel [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, BR-09913130 Diadema - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CELLS; v. 8, n. 9 SEP 2019.
Web of Science Citations: 0

Obesity is defined as a condition of abnormal or excessive fat accumulation in white adipose tissue that results from the exacerbated consumption of calories associated with low energy expenditure. Fat accumulation in both adipose tissue and other organs contributes to a systemic inflammation leading to the development of metabolic disorders such as type 2 diabetes, hypertension, and dyslipidemia. Melatonin is a potent antioxidant and improves inflammatory processes and energy metabolism. Using male mice fed a high-fat diet (HFD-59% fat from lard and soybean oil; 9:1) as an obesity model, we investigated the effects of melatonin supplementation on the prevention of obesity-associated complications through an analysis of plasma biochemical profile, body and fat depots mass, adipocytes size and inflammatory cytokines expression in epididymal (EPI) adipose depot. Melatonin prevented a gain of body weight and fat depot mass as well as adipocyte hypertrophy. Melatonin also reversed the increase of total cholesterol, triglycerides and LDL-cholesterol. In addition, this neurohormone was effective in completely decreasing the inflammatory cytokines leptin and resistin in plasma. In the EPI depot, melatonin reversed the increase of leptin, Il-6, Mcp-1 and Tnf-alpha triggered by obesity. These data allow us to infer that melatonin presents an anti-obesity effect since it acts to prevent the progression of pro-inflammatory markers in the epididymal adipose tissue together with a reduction in adiposity. (AU)

FAPESP's process: 15/03554-2 - The effects of melatonin supplementation on the development of obesity in mice
Grantee:Talita da Silva Mendes de Farias Carvalho
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/07638-9 - Melatonin supplementation effect on trans-differentation process from white adipose tissue to brown adipose tissue in obese mice
Grantee:Talita da Silva Mendes de Farias Carvalho
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 18/05485-6 - Effects of high fat diet and supplementation with omega-7 and omega-3 fatty acids on the browning process, proliferation and differentiation of mesenchymal cells contained in the stromal cell fraction from adipose tissue
Grantee:Maria Isabel Cardoso Alonso-Vale
Support Opportunities: Regular Research Grants