The effects of melatonin supplementation on the development of obesity in mice

• Grant number: 15/03554-2
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): June 01, 2015
• Effective date (End): September 30, 2019
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal researcher: Maria Isabel Cardoso Alonso-Vale
• Grantee: Talita da Silva Mendes de Farias Carvalho
• Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated scholarship(s): 16/07638-9 - Melatonin supplementation effect on trans-differentation process from white adipose tissue to brown adipose tissue in obese mice, BE.EP.PD

Abstract

Obesity is a chronic disease defined as the excessive accumulation of body lipids in adipose tissue and ectopically in other tissues such as the liver, pancreas and skeletal muscle, and it can be associated with other comorbidities such as type 2 diabetes mellitus, myocardial infarction, hypertension, and some cancers. The incidence of obesity worldwide is increasing every year, and this is an indication that the therapeutic strategies used to date are not yet fully effective. Studies have shown that melatonin is a hormone responsible for ensuring an adequate energy balance, mainly through the regulation of energy flow, probably through the activation of brown adipose tissue metabolism. In addition, studies show that melatonin has the capacity to promote the "browning" of white adipose tissue, thereby assisting in the regulation of body weight. However, studies evaluating the action of melatonin on brown adipose tissue metabolism are still incipient. Thus, this study aims to investigate how melatonin supplementation interferes with the physiology of white and brown adipose tissues on rats fed high fat diet. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA CUNHA DE SA, ROBERTA D. C.; CRUZ, MAYSA M.; DE FARIAS, TALITA M.; DA SILVA, VIVIANE S.; SIMAO, JUSSARA DE JESUS; TELLES, MONICA M.; ALONSO-VALE, MARIA ISABEL C. Fish oil reverses metabolic syndrome, adipocyte dysfunction, and altered adipokines secretion triggered by high-fat diet-induced obesity. PHYSIOLOGICAL REPORTS, v. 8, n. 4 FEB 2020. Web of Science Citations: 0.

MENDES DE FARIAS, TALITA DA SILVA; CRUZ, MAYSA MARIANA; DA CUNHA DE SA, ROBERTA CAVALCANTE; SEVERI, ILENIA; PERUGINI, JESSICA; SENZACQUA, MARTINA; CERUTTI, SUZETE MARIA; GIORDANO, ANTONIO; CINTI, SAVERIO; CARDOSO ALONSO-VALE, MARIA ISABEL. Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice. FRONTIERS IN ENDOCRINOLOGY, v. 10, NOV 5 2019. Web of Science Citations: 0.

MENDES DE FARIAS, TALITA DA SILVA; DA PAIXAO, REGISLANE INO; CRUZ, MAYSA MARIANA; CAVALCANTE DA CUNHA DE SA, ROBERTA DOURADO; SIMAO, JUSSARA DE JESUS; ANTRACO, VITOR JACO; CARDOSO ALONSO-VALE, MARIA ISABEL. Melatonin Supplementation Attenuates the Pro-Inflammatory Adipokines Expression in Visceral Fat from Obese Mice Induced by A High-Fat Diet. CELLS, v. 8, n. 9 SEP 2019. Web of Science Citations: 0.