Assessment of inflammatory and functional features along with risk factors associated to chronic obstructive pulmonary disease of pediatric patients

• Grant number: 16/22102-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2018
• End date: September 30, 2021
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Adyléia Aparecida Dalbo Contrera Toro
• Grantee: Adyléia Aparecida Dalbo Contrera Toro
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: André Moreno Morcillo ; Antonio Fernando Ribeiro ; Jose Dirceu Ribeiro ; Maria Angela Gonçalves de Oliveira Ribeiro ; Maria de Fátima Corrêa Pimenta Servidoni ; Marina Simões Oliveira ; Natasha Yumi Matsunaga

Abstract

Introduction: Chronic obstructive pulmonary diseases (COPDs) in pediatric patients, such as recurrent wheezing, asthma and cystic fibrosis are associated to higher demand from health system; costs of emergencies consults; medication for crisis; exacerbations and hospital admissions; and worst quality of life for patients and their families. Objective: To assess the inflammatory and functional features, and the risks factors associated to chronic obstructive pulmonary diseases in pediatric patients. Materials and methods: Prospective comparative study with infants, children and adolescents, aged 2 months to 17 years old, diagnosed with COPDs attending to the Outpatient Clinic Center from Clinics Hospital of University of Campinas (Unicamp). Parents and legal guardians will fill out an evaluation form with clinical and family history information. In order to assess cellularity and inflammatory profile, all patients will perform the sputum induction technique and blood draw, which will be used to eosinofil and neutrophil count; interleukine assessment using CBA kits and flow citometry; and vitamin D dosage. To assess the functional characteristic, spirometry and the Six Minute Walk Test will be performed in subjects 7 years and older. The collected data will be stored and analyzed by SPSS 16.0 Windows software (SPSS Inc., Chicago, IL; EUA) (p=5%). (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MATSUNAGA, NATASHA YUMI; GIANFRANCESCO, LIVEA; MAZZOLA, TAIS NITSCH; OLIVEIRA, MARINA SIMOES; MORCILLO, ANDRE MORENO; RIBEIRO, MARIA ANGELA GONCALVES OLIVEIRA; RIBEIRO, JOSE DIRCEU; HASHIMOTO, SIMONE; TORO, ADYLEIA APARECIDA DALBO CONTRERA. ifferences between patients who achieved asthma control and those who remain uncontrolled after standardized severe asthma care strateg. JOURNAL OF ASTHMA, v. 59, n. 2, NOV 2020. (16/22102-8)

NATASHA YUMI MATSUNAGA; CAIO DE OLIVEIRA; LIVEA GIANFRANCESCO; MARINA SIMÕES OLIVEIRA; MARIA CRISTINA RIBEIRO DOS SANTOS SIMÕES; ANDRÉ MORENO MORCILLO; JOSÉ DIRCEU RIBEIRO; MARIA ANGELA GONÇALVES DE OLIVEIRA RIBEIRO; ADYLÉIA APARECIDA DALBO CONTRERA TORO. Avaliação do controle da asma entre diferentes medidas e avaliação da capacidade de exercício funcional em crianças e adolescentes com asma. Jornal Brasileiro de Pneumologia, v. 46, n. 3, 2020-03-13. (16/22102-8)

MARIANA BUENO MANINI; NATASHA YUMI MATSUNAGA; LÍVEA GIANFRANCESCO; MARINA SIMÕES OLIVEIRA; MARIA ROSA VIEIRA DE CARVALHO; GISLEINE LEILA MARTINS TENGLER RIBEIRO; ELIANE DE OLIVEIRA MORAIS; MARIA ANGELA GONÇALVES O. RIBEIRO; ANDRÉ MORENO MORCILLO; JOSÉ DIRCEU RIBEIRO; et al. Fatores de risco para sibilância recorrente em crianças pré-termo que receberam profilaxia com palivizumabe. Jornal Brasileiro de Pneumologia, v. 47, n. 5, 2021-10-15. (16/22102-8)

GIANFRANCESCO, LIVEA; GABAN MALHEIRO, ANA PAULA; MATSUNAGA, NATASHA YUMI; OLIVEIRA, MARINA SIMOES; GROTTA, MILENA BAPTISTELLA; MORCILLO, ANDRE MORENO; RIBEIRO, JOSE DIRCEU; DALBO CONTRERA TORO, ADYLEIA APARECIDA. Are there differences in the physical activity level and functional capacity among children and adolescents with and without asthma?. Jornal de Pediatria, v. 97, n. 3, p. 295-301, MAY-JUN 2021. (16/22102-8)

MALHEIRO, ANA PAULA G.; GIANFRANCESCO, LIVEA; NOGUEIRA, ROBERTO JOSE N.; GROTTA, MILENA B.; MORCILLO, ANDRE M.; RIBEIRO, JOSE DIRCEU; TORO, ADYLEIA A. D. C.. Association between serum Vitamin D levels and asthma severity and control in children and adolescents. Lung, v. N/A, p. 7-pg., 2023-02-21. (16/22102-8)

MATSUNAGA, NATASHA YUMI; GIANFRANCESCO, LIVEA; MAZZOLA, TAIS NITSCH; OLIVEIRA, MARINA SIMOES; MORCILLO, ANDRE MORENO; RIBEIRO, MARIA ANGELA GONCALVES OLIVEIRA; RIBEIRO, JOSE DIRCEU; HASHIMOTO, SIMONE; TORO, ADYLEIA APARECIDA DALBO CONTRERA. Differences between patients who achieved asthma control and those who remain uncontrolled after standardized severe asthma care strategy. JOURNAL OF ASTHMA, v. 59, n. 2, p. 8-pg., 2020-11-19. (16/22102-8)