CORTICOBASAL SYNDROME: CLINICAL AND PHYSIOPATHOLOGICAL CORRELATES.

• Grant number: 17/10033-4
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2018
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Sonia Maria Dozzi Brucki
• Grantee: Sonia Maria Dozzi Brucki
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Artur Martins Novaes Coutinho ; Carlos Alberto Buchpiguel ; Claudia da Costa Leite ; Jacy Bezerra Parmera

Abstract

Introduction: Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome of great interest to movement disorders specialists and behavioral neurologists. Although originally considered a primary motor disorder, it is now also recognized as a cognitive disorder, usually presenting cognitive deficits before the onset of motor symptoms. The term CBS denotes the clinical phenotype and is associated with a heterogeneous spectrum of pathologies. Given that disease-modifying agents are targeting the pathologic process, new diagnostic methods and biomarkers are being developed to predict the underlying pathology. Objectives: To analyse a cohort of patients with CBS through neuropsychological and neurological assessment to evaluate the presence of biomarkers to amyloid(utilizing Positron Emission Tomography with Pitsburg compound) and Tau pathology (Positron Emission Tomography with deoxy- fluoro- glucose and Magnetic Ressonance Imaging). Methods: these patients will be assessed longitudinally in the movement disorders and behavioral neurology outpatient service of Hospital das Clínicas, University of São Paulo. They will be compared to purpose a correlation between clinical assessment and biomarkers of Tau and Amyloid pathology. (AU)

Scientific publications

(6)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

PARMERA, JACY BEZERRA; DE ALMEIDA, ISABEL JUNQUEIRA; BARBOSA DE OLIVEIRA, MARCOS CASTELLO; SILAGI, MARCELA LIMA; CARNEIRO, CAMILA DE GODOI; STUDART-NETO, ADALBERTO; ONO, CARLA RACHEL; BARBOSA, EGBERTO REIS; NITRINI, RICARDO; BUCHPIGUEL, CARLOS ALBERTO; et al. Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study. FRONTIERS IN NEUROLOGY, v. 12, AUG 30 2021. (17/10033-4)

PARMERA, JACY BEZERRA; BRUCKI, SONIA MARIA DOZZI; COUTINHO, ARTUR MARTINS; NITRINI, RICARDO. Foot-Hand Synkinesis in Corticobasal Syndrome: Single Clinical Feature with Distinct Molecular Imaging Biomarkers. MOVEMENT DISORDERS CLINICAL PRACTICE, v. 8, n. 3, MAR 2021. (17/10033-4)

PARMERA, JACY BEZERRA; COUTINHO, ARTUR MARTINS; ARANHA, MATEUS ROZALEM; STUDART-NETO, ADALBERTO; DE GODOI CARNEIRO, CAMILA; DE ALMEIDA, ISABEL JUNQUEIRA; FONTOURA SOLLA, DAVI J.; ONO, CARLA RACHEL; BARBOSA, EGBERTO REIS; NITRINI, RICARDO; et al. FDG-PET Patterns Predict Amyloid Deposition and Clinical Profile in Corticobasal Syndrome. MOVEMENT DISORDERS, NOV 2020. (17/10033-4)

PARMERA, JACY BEZERRA; COUTINHO, ARTUR MARTINS; GUIMARAES, THIAGO GONCALVES; YAMAMOTO, JOYCE YURI SILVESTRE; TAKADA, LEONEL TADAO; NITRINI, RICARDO; BARBOSA, EGBERTO REIS; BRUCKI, SONIA MARIA DOZZI. Expanding MAPT p.V363I Mutation Phenotype: An Overlapping of PSP-CBS and Posterior Cortical Atrophy. MOVEMENT DISORDERS CLINICAL PRACTICE, v. N/A, p. 3-pg., 2023-02-14. (17/10033-4)

BARBOSA, BRENO JOSE ALENCAR PIRES; DE SOUZA-TALARICO, JULIANA NERY; DE JESUS, MARIA CLARA FERREIRA; MOTA, GABRIEL PAZ SOUZA; DE OLIVEIRA, MAIRA OKADA; CASSIMIRO, LUCIANA; AVOLIO, ISABELLA MARIA BELLO; TRES, EDUARDO STURZENEKER; BORGES, CONRADO REGIS; TEIXEIRA, THIAGO BEZERRA MORAES; et al. Allostatic load measures in older adults with subjective cognitive decline and mild cognitive impairment: A cross-sectional analysis from the Brazilian Memory and Aging Study. CLINICAL NEUROLOGY AND NEUROSURGERY, v. 243, p. 7-pg., 2024-06-08. (17/10033-4, 21/01459-3)

PARMERA, JACY BEZERRA; COUTINHO, ARTUR MARTINS; ARANHA, MATEUS ROZALEM; STUDART-NETO, ADALBERTO; DE GODOI CARNEIRO, CAMILA; DE ALMEIDA, ISABEL JUNQUEIRA; FONTOURA SOLLA, DAVI J.; ONO, CARLA RACHEL; BARBOSA, EGBERTO REIS; NITRINI, RICARDO; et al. FDG-PET Patterns Predict Amyloid Deposition and Clinical Profile in Corticobasal Syndrome. MOVEMENT DISORDERS, v. 36, n. 3, p. 11-pg., 2020-11-18. (17/10033-4)