Effects of carbohydrate and glutamine supplementation on parameters of innate immune response and inflammation during and after exercise in hypoxia

• Grant number: 17/26563-2
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2018
• End date: August 31, 2020
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal Investigator: Ronaldo Vagner Thomatieli dos Santos
• Grantee: Ronaldo Vagner Thomatieli dos Santos
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

In the last 20 years there has been a growing number of studies trying to explain the relationship between the immune system, central nervous system and exercise. It is now known that exercise can be immunomodulatory, stimulating or inhibiting the immune response. On the other hand, exercise in hypoxia can be considered a potent immunosuppressive and inflammatory agent, mainly because of its capacity to increase the concentration of stress hormones such as catecholamines and cortisol, to decrease the concentration of glutamine since it represents an additional stress to the organism beyond that caused by exercise. On the other hand, recent evidence suggests that carbohydrate and glutamine supplementation have the power to attenuate the effects of exercise on hypoxia on the adaptive immune response. Thus, this study intends to evaluate the effects of carbohydrate and glutamine supplementation on parameters of innate immune response and inflammation during and after exercise in hypoxia simulating altitude of 4500m. Thus, this study proposes to evaluate 15 male volunteers, between 18 and 30 years old, submitted to three procedures on different days, and the control groups will perform exercise at 70% VO2peak at simulated altitude of 4500m, without supplementation and those that will perform at altitude supplemented with carbohydrate and / or glutamine. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAVARES-SILVA, E.; DONATTO, F. F.; MEDEIROS, V, R. M.; SANTOS, S. A.; CARIS, V, A.; THOMATIELI-SANTOS, V, R.. Carbohydrate supplementation and psychophysiological responses during moderate exercise in hypoxia. JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, v. 17, n. 1, JAN 6 2020. (17/26563-2)

CARIS, V, ALINE; TAVARES-SILVA, EDGAR; THOMATIELI-SANTOS, V, RONALDO. Effects of carbohydrate and glutamine supplementation on cytokine production by monocytes after exercise in hypoxia: A crossover, randomized, double-blind pilot study. NUTRITION, v. 70, FEB 2020. (17/26563-2)

ARAUJO MINARI, ANDRE LUIS; AVILA, FELIPE; OYAMA, LILA MISSAE; THOMATIELI-SANTOS, RONALDO VAGNER. Skeletal muscles induce recruitment of Ly6C(+) macrophage subtypes and release inflammatory cytokines 3 days after downhill exercise. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 317, n. 4, p. R597-R605, OCT 2019. (17/26563-2, 16/06817-7)

CARIS, V, ALINE; THOMATIELI-SANTOS, V, RONALDO. Carbohydrate and Glutamine Supplementation Attenuates the Increase in Rating of Perceived Exertion during Intense Exercise in Hypoxia Similar to 4200 m. NUTRIENTS, v. 12, n. 12, DEC 2020. (17/26563-2)

TAVARES-SILVA, EDGAR; CARIS, ALINE VENTICINQUE; SANTOS, SAMILE AMORIN; RAVACCI, GRAZIELA ROSA; THOMATIELI-SANTOS, RONALDO VAGNER. Effect of Multi-Strain Probiotic Supplementation on URTI Symptoms and Cytokine Production by Monocytes after a Marathon Race: A Randomized, Double-Blind, Placebo Study. NUTRIENTS, v. 13, n. 5, MAY 2021. (17/26563-2)

DOS SANTOS QUARESMA, M. V. L.; SOUZA, W. Y. G.; LEMOS, V. A.; CARIS, V, A.; THOMATIELI-SANTOS, V, R.. The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude. NUTRIENTS, v. 12, n. 12, DEC 2020. (17/26563-2)