Search for potential antitumoral, antioxidant, antiinflammatory, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest

• Grant number: 04/07932-7
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• Start date: March 01, 2005
• End date: July 31, 2010
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Dulce Helena Siqueira Silva
• Grantee: Dulce Helena Siqueira Silva
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Pesquisadores principais: Alberto Jose Cavalheiro
• Associated research grant(s): 07/51452-8 - Rapid screening of antioxidant and antimalarial compounds from natural complex matrixes using hplc-micro fraction analysis: application to crude extracts from chiococca alba., AR.EXT
• Associated scholarship(s): 07/50348-2 - Biomonitored phytochemical study of Casearia lasiophylla (Flacourtiaceae), BP.IC; 06/60150-2 - Configurational analysis of styrylpyrones of species of Cryptocarya (Lauraceae), BP.IC; 06/60151-9 - Chromatographic profile of the metabolites of species of the Flacourtiaceae family: biomonitored phytochemcial study, BP.DR; + associated scholarships 06/60152-5 - Optimization and validation of method for the extraction and analysis of casearines of Casearia sylvestris, by CLAE, BP.IC; 06/60891-2 - Tracing of genotoxicity of antimutagenesis of semi-purified fractions extracted from Pterogyne nitens using the test of the micronucleus in Tradescantia pallida, BP.IC; 06/57101-0 - Phytochemical study of the antioxidant and cytotoxic activities of Myrciaria cauliflora Berg. (Myrtaceae), BP.IC; 06/57114-4 - Implantation of trials for triage on a greater scale using a micro-circuit board multidetection reader for analysis of vegetal extracts and substances, BP.PD; 06/55162-1 - Chemical and antioxidant studies of two species of the Lippia genus native to the São Paulo cerrado: L. salviaefolia and L. velutina (Berbenaceae), BP.DR; 05/60029-6 - Antiproliferative and cytoxic evaluation of potential inhibitors of hypusination of the factor of the 5th translation initiation (EIF5A), BP.IC; 05/56867-6 - Search for potential antitumoral, antioxidant, antiinflammatory, antifungal, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest, BP.TT; 05/52930-5 - Chemical study and study of the biological activities of Eugenia jambolana (Myrtaceae), BP.MS - associated scholarships

Abstract

The changing strategies for preservation and sustainable of diversity in Brazil in the past few years evidences the intrinsic value this enormous biological resource of potentially new bioactive compounds, and represents one of the greatest challenges nowadays facing the accelerated process of devastation of several Brazilian biomes. The systematic bioactivity evaluation of crude extracts and pure compounds from São Paulo state biota associated with additional information on chromatographic profile, spectrometric data and/or biological activity shall result in value-added material, which will be available for further studies. The might converge to hits or lead compounds to pharmaceutical, agroceutical, nutraceutical, cosmetics industry, which is expected to bring great contribution for conservation and sustainable economic development from the biodiversity of São Paulo state. (AU)

Scientific publications

(15)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CRISTIANO S. FUNARI; LETÍCIA DE ALMEIDA; THAIS G. PASSALACQUA; ISABEL MARTINEZ; DANIELA L. AMBRÓSIO; REGINA MARIA B. CICARELLI; DULCE HELENA S. SILVA; MÁRCIA A. S. GRAMINHA. Ácido oleanônico isolado de Lippia lupulina (Verbenaceae) apresenta potentes atividades leishmanicida e tripanocida. Acta Amazonica, v. 46, n. 4, p. 411-416, 2016-12-00. (04/07932-7, 06/55162-1)

SARA REGINA DE MARQUI; RENATA BRIONÍZIO LEMOS; LUCIANA ÁVILA SANTOS; IAN CASTRO-GAMBOA; ALBERTO JOSÉ CAVALHEIRO; VANDERLAN DA SILVA BOLZANI; DULCE HELENA SIQUEIRA SILVA; LILIANA SCORZONI; ANA MARIA FUSCO-ALMEIDA; MARIA JOSÉ SOARES MENDES-GIANNINI; et al. Saponinas antifúngicas de Swartzia langsdorffii. Química Nova, v. 31, n. 4, p. 828-831, 2008-00-00. (04/07932-7, 03/02176-7)

FUNARI, CRISTIANO SOLEO; GULLO, FERNANDA PATRICIA; NAPOLITANO, ASSUNTA; CARNEIRO, RENATO LAJARIM; SOARES MENDES-GIANNINI, MARIA JOSE; FUSCO-ALMEIDA, ANA MARISA; PIACENTE, SONIA; PIZZA, COSIMO; SIQUEIRA SILVA, DULCE HELENA. Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil. Food Chemistry, v. 135, n. 3, p. 2086-2094, DEC 1 2012. (04/07932-7)

MORAIS, MAURO C. C.; LUQMAN, SUAIB; KONDRATYUK, TAMARA P.; PETRONIO, MAICON S.; REGASINI, LUIS O.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; SOARES, CHRISTIANE P.; PEZZUTO, JOHN M.. Suppression of TNF- induced NFB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. NATURAL PRODUCT RESEARCH, v. 24, n. 18, p. 1758-1765, 2010. (04/07932-7)

DAMETTO, ALESSANDRA C.; BORALLE, NIVALDO; ZHANG, CHUAN-RUI; SILVA, DULCE H. S.; NAIR, MURALEEDHARAN G.. Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds. NATURAL PRODUCT COMMUNICATIONS, v. 13, n. 8, p. 977-980, AUG 2018. (13/07600-3, 04/07932-7)

DAMETTO, ALESSANDRA C.; AGUSTONI, DANIELE; MOREIRA, THAIS F.; PLAZA, CARENINA V.; PRIETO, ALINE M.; SILVA, TARSIA G. A.; SOUZA, FELIPE O.; BORALLE, NIVALDO; SORBO, JULIANA MARIA; SILVA, DULCE H. S.; et al. Chemical composition and in vitro chemoprevention assessment of Eugenia jambolana Lam. (Myrtaceae) fruits and leaves. Journal of Functional Foods, v. 36, p. 490-502, SEP 2017. (13/07600-3, 04/07932-7)

FERNANDES, DANIARA CRISTINA; REGASINI, LUIS OCTÁVIO; VELLOSA, JOSÉ CARLOS REBUGLIO; PAULETTI, PATRÍCIA MENDONÇA; CASTRO-GAMBOA, IAN; BOLZANI, VANDERLAN SILVA; OLIVEIRA, OLGA MARIA MASCARENHAS; SILVA, DULCE HELENA SIQUEIRA. Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. Chemical & Pharmaceutical Bulletin, v. 56, n. 5, p. 723-726, May 2008. (04/07932-7)

ORLANDI SARDI, JANAINA DE CASSIA; PITANGUI, NAYLA DE SOUZA; RODRIGUEZ-ARELLANES, GABRIELA; LUCIA TAYLOR, MARIA; FUSCO-ALMEIDA, ANA MARIA; SOARES MENDES-GIANNINI, MARIA JOSE. Highlights in pathogenic fungal biofilms. REVISTA IBEROAMERICANA DE MICOLOGIA, v. 31, n. 1, p. 22-29, JAN 31 2014. (11/12734-3, 03/02176-7, 04/07932-7, 12/01270-9)

FUNARI, CRISTIANO SOLEO; PASSALACQUA, THAIS GABAN; RINALDO, DANIEL; NAPOLITANO, ASSUNTA; FESTA, MICHELA; CAPASSO, ANNA; PIACENTE, SONIA; PIZZA, COSIMO; MARX YOUNG, MARIA CLAUDIA; DURIGAN, GISELDA; et al. Interconverting flavanone glucosides and other phenolic compounds in Lippia salviaefolia Cham. ethanol extracts. Phytochemistry, v. 72, n. 16, p. 2052-2061, NOV 2011. (04/07932-7)

PRIETO, ALINE M.; DOS SANTOS, ANDRE G.; OLIVEIRA, ANA PAULA S.; CAVALHEIRO, ALBERTO J.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; VARANDA, ELIANA AP.; SOARES, CHRISTIANE P.. Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae). Food and Chemical Toxicology, v. 53, p. 153-159, MAR 2013. (03/02176-7, 04/07932-7)

REGASINI, LUIS OCTAVIO; PIVATTO, MARCOS; SCORZONI, LILIANA; BENADUCCI, TATIANE; FUSCO-ALMEIDA, ANA MARISA; SOARES MENDES GIANNINI, MARIA JOSE; BARREIRO, ELIEZER JESUS; SIQUEIRA SIVA, DULCE HELENA; BOLZANI, VANDERLAN DA SILVA. Atividade antimicrobiana de Pterogyne nitens Tul., Fabaceae, contra fungos oportunistas. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 20, n. 5, p. 706-711, OCT-NOV 2010. (04/07932-7)

DE OLIVEIRA, ALINE M.; DOS SANTOS, ANDRE G.; DOS SANTOS, RAQUEL A.; CSIPAK, ANGELICA R.; OLIVATO, CAMILA; DA SILVA, ISABEL C.; DE FREITAS, MAURA B.; BASSI, CARMEN L.; CAVALHEIRO, ALBERTO J.; BOLZANI, VANDERLAN S.; et al. Ethanolic extract of Casearia sylvestris and its clerodane diterpen (caseargrewiin F) protect against DNA damage at low concentrations and cause DNA damage at high concentrations in mice's blood cells. MUTAGENESIS, v. 24, n. 6, p. 501-506, NOV 2009. (03/02176-7, 04/07932-7)

FLAUSINO, JR., O. A.; DUFAU, L.; REGASINI, L. O.; PETRONIO, M. S.; SILVA, D. H. S.; ROSE, T.; BOLZANI, V. S.; REBOUD-RAVAUX, M.. Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization. Current Medicinal Chemistry, v. 19, n. 26, p. 4534-4540, SEP 2012. (03/02176-7, 04/07932-7)

PRIETO, A. M.; SANTOS, A. G.; CSIPAK, A. R.; CALIRI, C. M.; SILVA, I. C.; ARBEX, M. A.; SILVA, F. S.; MARCHI, M. R. R.; CAVALHEIRO, A. J.; SILVA, D. H. S.; et al. Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil. Toxicology and Applied Pharmacology, v. 265, n. 3, p. 368-372, DEC 15 2012. (03/02176-7, 04/07932-7)

LUIS OCTÁVIO REGASINI; GERARDO MAGELA VIEIRA-JÚNIOR; DANIARA CRISTINA FERNANDES; VANDERLAN DA SILVA BOLZANI; ALBERTO JOSÉ CAVALHEIRO; DULCE HELENA SIQUEIRA SILVA. IDENTIFICATION OF TRITERPENES AND STEROLS FROM PTEROGYNE NITENS (FABACEAE-CAESALPINIOIDEAE) USING HIGH-RESOLUTION GAS CHROMATOGRAPHY. Journal of the Chilean Chemical Society, v. 54, n. 3, p. 218-221, 2009-00-00. (04/07932-7)