Natural products from plants of Cerrado and Atlantic Forest, potential models and useful for identifying prototypes with oxidizing action on neutrophils and myeloperoxidase (MPO) enzyme

• Grant number: 11/03017-6
• Support Opportunities: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): June 01, 2011
• Effective date (End): September 30, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Vanderlan da Silva Bolzani
• Grantee: Maria Luiza Zeraik
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID

Abstract

Neutrophils play a key role in defending the body against invading microorganisms by phagocytosis, the degranulation, release of myeloperoxidase (MPO) and consequent production of reactive oxygen species (ROS). The ROS produced and released by MPO is essential against microbes phagocytosed and when released into the extracellular environment can cause oxidative damage to host tissues. These lesions have been correlated to numerous diseases such as atherosclerosis, rheumatoid arthritis, and cancer. In order to prevent such oxidative damage the antioxidant activity, anti-inflammatory and antitumor of various substances, especially those derived from plants were investigated. The goal of this work is the implementation and consolidation of trials of antioxidant, anti-inflammatory and anti-tumor in laboratory NuBBE, aiming a qualitative leap in the screening of compounds with anti-inflammatory and anti-tumor activities. The establishment of fast, efficient enzymatic assays, high reliability and reproducibility in Natural Products Chemistry laboratory will be of great value for research in the area, considering the added value potential of a bioprospecting rationally planned. Natural compounds and some semi-synthetic derivatives of these natural products available on NuBBE database will be used in all tests.

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHAPLA, VANESSA MARA; ZERAIK, MARIA LUIZA; LEPTOKARYDIS, IOANIS HCRISTOS; SILVA, GERALDO HUMBERTO; BOLZANI, VANDERLAN SILVA; YOUNG, MARIA CLAUDIA M.; PFENNING, LUDWIG HEINRICH; ARAUJO, ANGELA REGINA. Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca. Molecules, v. 19, n. 11, p. 19243-19252, NOV 2014. (03/02176-7, 13/07600-3, 11/03017-6)

ZERAIK, M. L.; XIMENES, V. F.; REGASINI, L. O.; DUTRA, L. A.; SILVA, D. H. S.; FONSECA, L. M.; COELHO, D.; MACHADO, S. A. S.; BOLZANI, V. S.. 4 `-Aminochalcones As Novel Inhibitors of the Chlorinating Activity of Myeloperoxidase. Current Medicinal Chemistry, v. 19, n. 31, p. 5405-5413, NOV 2012. (11/03017-6)

ARWA, PHANUEL SARONI; ZERAIK, MARIA LUIZA; XIMENES, VALDECIR FARIAS; DA FONSECA, LUIZ MARCOS; BOLZANI, VANDERLAN DA SILVA; SIQUEIRA SILVA, DULCE HELENA. Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage. Journal of Ethnopharmacology, v. 174, p. 410-418, NOV 4 2015. (13/07600-3, 11/03017-6)

ZERAIK, MARIA LUIZA; QUEIROZ, EMERSON FERREIRA; MARCOURT, LAURENCE; CICLET, OLIVIER; CASTRO-GAMBOA, IAN; SIQUEIRA SILVA, DULCE HELENA; CUENDET, MURIEL; BOLZANI, VANDERLAN DA SILVA; WOLFENDER, JEAN-LUC. Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits. Journal of Functional Foods, v. 21, p. 396-405, MAR 2016. (13/07600-3, 11/03017-6)

ZERAIK, MARIA LUIZA; PETRONIO, MAICON S.; COELHO, DYOVANI; REGASINI, LUIS OCTAVIO; SILVA, DULCE H. S.; DA FONSECA, LUIZ MARCOS; MACHADO, SERGIO A. S.; BOLZANI, VANDERLAN S.; XIMENES, VALDECIR F.. Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification. PLoS One, v. 9, n. 10, OCT 23 2014. (11/03017-6, 13/07600-3, 13/08784-0)

VENTURINI, DIEGO; PASTRELLO, BRUNA; ZERAIK, MARIA LUIZA; PAULI, IVANI; ANDRICOPULO, ADRIANO DEFINI; SILVA-FILHO, LUIZ CARLOS; BOLZANI, V. S.; MORGON, NELSON HENRIQUE; DA SOUZA, A. R.; XIMENES, VALDECIR FARIAS. Experimental, DFT and docking simulations of the binding of diapocynin to human serum albumin: induced circular dichroism. RSC ADVANCES, v. 5, n. 76, p. 62220-62228, 2015. (11/03017-6, 13/07600-3, 13/08784-0)

ZERAIK, MARIA LUIZA; PAULI, IVANI; DUTRA, LUIZ A.; CRUZ, RAQUEL S.; VALLI, MARILIA; PARACATU, LUANA C.; DE FARIA, CAROLINA M. Q. G.; XIMENES, VALDECIR F.; REGASINI, LUIS O.; ANDRICOPULO, ADRIANO D.; et al. Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Screening, Biochemical Evaluation and Molecular Modeling Studies. Molecules, v. 26, n. 8, APR 2021. (10/01506-7, 13/07600-3, 11/03017-6, 19/05967-3, 19/18445-5, 09/15457-0, 14/50926-0)

CHAPLA, VANESSA M.; ZERAIK, MARIA L.; CAFEU, MARIANA C.; SILVA, GERALDO H.; CAVALHEIRO, ALBERTO J.; BOLZANI, VANDERLAN S.; YOUNG, MARIA C. M.; PFENNING, LUDWIG H.; ARAUJO, ANGELA R.. Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities. Journal of the Brazilian Chemical Society, v. 29, n. 8, p. 1707-1713, AUG 2018. (03/02176-7, 11/03017-6, 13/07600-3)

SILVA, GERALD H.; ZERAIK, MARIA L.; DE OLIVEIRA, CAMILA M.; TELES, HELDER L.; TREVISAN, HENRIQUE C.; PFENNING, LUDWIG H.; NICOLLI, CAMILA P.; YOUNG, MARIA C. M.; MASCARENHAS, YVONNE P.; ABREU, LUCAS M.; et al. Lactone Derivatives Produced by a Phaeoacremonium sp., an Endophytic Fungus from Senna spectabilis. Journal of Natural Products, v. 80, n. 5, p. 1674-1678, MAY 2017. (03/02176-7, 13/07600-3, 11/03017-6)