Lipid Modification and Signaling through CD36 Receptor in the Nervous System

• Grant number: 18/18633-3
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2019
• End date: July 31, 2021
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Isaias Glezer
• Grantee: Isaias Glezer
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Bettina Malnic ; Marcos Yukio Yoshinaga ; Sayuri Miyamoto

Abstract

CD36 is a membrane glycoprotein associated with various biological processes, including fatty acids internalization and utilization, and ligand presentation for receptors that activate innate immune system cells. CD36 is a multifunctional receptor due to its presence in varied cell types and also for the diversity of its unrelated ligands. Recently, we characterized CD36 expression in a subpopulation of olfactory sensory neurons (OSNs). However, more studies are necessary in order to elucidate CD36 physiological roles in the nervous system. As only one odorant receptor (OR/Olfr) transcript has been unequivocally identified in CD36-positive OSNs, we plan to characterize other olfactory related genes co-expressed with Cd36. In addition, we aim to analyze if there is any functional relationship between the identified receptors and CD36. We will also use global expression profile (transcriptomics) in order to reveal genes impacted by CD36 genetic ablation in order to search for molecular functions that are singular for CD36-positive OSNs. Lastly, we plan to investigate lipid composition changes in different tissues in order to evaluate the impact of CD36-loss of function. Altogether, the different approaches will help to reveal CD36 roles in the nervous system. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GLEZER, ISAIAS; BRUNI-CARDOSO, ALEXANDRE; SCHECHTMAN, DEBORAH; MALNIC, BETTINA. Viral infection and smell loss: The case of COVID-19. Journal of Neurochemistry, v. 157, n. 4, p. 930-943, MAY 2021. (19/26767-2, 19/06982-6, 13/07937-8, 18/18633-3)

SBRANA, MARIANA FERREIRA; FORNAZIERI, MARCO AURELIO; BRUNI-CARDOSO, ALEXANDRE; AVELINO-SILVA, I, VIVIAN; SCHECHTMAN, DEBORAH; VOEGELS, RICHARD LOUIS; MALNIC, BETTINA; GLEZER, ISAIAS; PINNA, FABIO DE REZENDE. Olfactory Dysfunction in Frontline Health Care Professionals During COVID-19 Pandemic in Brazil. FRONTIERS IN PHYSIOLOGY, v. 12, MAR 9 2021. (18/18633-3, 19/06982-6, 16/24471-0, 13/07937-8, 19/26767-2)

CHAVES-FILHO, ADRIANO BRITTO; DANTAS PINTO, ISABELLA FERNANDA; DANTAS, LUCAS SOUZA; XAVIER, ANDRE MACHADO; INAGUE, ALEX; FARIA, RODRIGO LUCAS; MEDEIROS, MARISA H. G.; GLEZER, ISAIAS; YOSHINAGA, MARCOS YUKIO; MIYAMOTO, SAYURI. Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis. SCIENTIFIC REPORTS, v. 9, AUG 12 2019. (18/18633-3, 13/07937-8)

DOS SANTOS, KARINA GAMA; YOSHINAGA, MARCOS YUKIO; GLEZER, ISAIAS; CHAVES-FILHO, ADRIANO DE BRITTO; DE SANTANA, ALINE ALVES; KOVACS, CRISTIANE; MAGNONI, CARLOS DANIEL; LAJOLO, FRANCO MARIA; MIYAMOTO, SAYURI; HASSIMOTTO, NEUZA MARIKO AYMOTO. Orange juice intake by obese and insulin-resistant subjects lowers specific plasma triglycerides: A randomized clinical trial*. CLINICAL NUTRITION ESPEN, v. 51, p. 9-pg., 2022-10-01. (13/07937-8, 20/08175-8, 18/18633-3, 13/07914-8)

MACEDO, FELIPE; DOS SANTOS, LUCAS SOUZA; GLEZER, ISAIAS; DA CUNHA, FEMANDA MARQUES. Brain Innate Immune Response in Diet-Induced Obesity as a Paradigm for Metabolic Influence on Inflammatory Signaling. FRONTIERS IN NEUROSCIENCE, v. 13, APR 24 2019. (15/15526-3, 13/07937-8, 18/18633-3)

CHAVES-FILHO, ADRIANO B.; DINIZ, LARISSA S.; SANTOS, ROSANGELA S.; LIMA, RODRIGO S.; ORELIANA, HECTOR; PINTO, ISABELLA F. D.; DANTAS, LUCAS S.; INAGUE, ALEX; FARIA, RODRIGO L.; MEDEIROS, MARISA H. G.; et al. Plasma oxylipin profiling by high resolution mass spectrometry reveal signatures of inflammation and hypermetabolism in amyotrophic lateral sclerosis. Free Radical Biology and Medicine, v. 208, p. 14-pg., 2023-08-25. (13/07937-8, 18/18633-3, 19/01763-4, 20/04159-8, 15/19530-5)