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Next generation inhibitors of switch region RNA polymerase


Based on the current shortcomings with M. tb. RNAP inhibitors, this project aims to build a collaborative TB drug discovery program, impacting human and scientific capabilities at both FCFRP/USP and H3D at University of Cape Town. Sharing critical scientific skills and capabilities between the University of Cape Town and the University of Sao Paolo will generate a well-established and fully integrated drug discovery group that provides a great training ground for early career scientists and could lead to a successful future grant application funding a robust plan to target RNAP switch region inhibitors. The research team involved in the project is multidisciplinary and will develop a series of activities including workshops, training, scientific meetings and experiments to generate one of basic expected outputs - a novel M. Tb. RNAP inhibitor. Furthermore, all activities will be critically analyzed to generate results and pave the way to a future grant application that will support the long-term collaboration expected. (AU)

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