GnRH ANALOG IS INEFFECTIVE IN INCREASING ADULT HEIGHT IN GIRLS WITH PUBERTY ONSET AFTER 7 YEARS OF AGE: A SYSTEMATIC REVIEW AND META-ANALYSIS

• Grant number: 18/20847-1
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: January 01, 2019
• End date: June 30, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Vania dos Santos Nunes Nogueira
• Grantee: Vania dos Santos Nunes Nogueira
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Objective: We assessed the effectiveness of puberty blockade with a gonadotropin-releasing hormone (GnRH) analog in increasing adult height (AH) in girls with puberty onset between 7 and 10 years of age. Methods: We performed a systematic review and included controlled studies in which girls with early puberty (EP) were assigned to the GnRH analog or no treatment groups. The primary outcome analyzed was AH. Search strategies were applied to the MEDLINE, Embase, LILACS, and CENTRAL databases. Results: We identified 1514 references, and six studies fulfilled our eligibility criteria. Two studies were randomized and four were not randomized. At the baseline of each trial, height, chronological age, bone age, predicted AH (PAH), and target height (TH) were equal between the groups. All studies used intramuscular triptorelin every 28 days in the intervention groups. The mean duration of the therapy was 2 years. Meta-analysis of AH among the six studies (comprising 332 girls) showed no significant difference between the groups (mean difference = 0.50 cm, 95% confidence interval = 0.72-1.73 cm, I2 = 0%). In a sub-group analysis based on PAH (<155 cm and 155 cm; and equal to TH), there was no difference in average AH between the groups. The quality of evidence according to the Grading of Recommendations Assessment, Development, and Evaluation approach was low. Conclusion: We found no evidence from controlled experimental and observational studies that compared with no treatment, the use of GnRH analogs improved AH in girls with EP (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANTUNES FRANZINI, ITALO; MASSAHITO YAMAMOTO, FABIO; BOLFI, FERNANDA; RAUBER ANTONINI, SONIR ROBERTO; NUNES-NOGUEIRA, VANIA DOS SANTOS. Comments on `Adult height after gonadotropin-releasing hormone agonist treatment in girls with early puberty: A meta-analysis'. CLINICAL ENDOCRINOLOGY, v. 93, n. 4, AUG 2020. (15/23447-6, 18/20847-1)

ANTUNES FRANZINI, ITALO; MASSAHITO YAMAMOTO, FABIO; BOLFI, FERNANDA; RAUBER ANTONINI, SONIR ROBERTO; NUNES-NOGUEIRA, VANIA DOS SANTOS. Comments on 'Adult height after gonadotropin-releasing hormone agonist treatment in girls with early puberty: A meta-analysis'. CLINICAL ENDOCRINOLOGY, v. 93, n. 4, p. 4-pg., 2020-08-08. (18/20847-1, 15/23447-6)