Development of a smart clinical equipment for phototherapies with automatic dosimetry calibration and on demand payment

• Grant number: 17/22406-0
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: March 01, 2019
• End date: January 31, 2020
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Caetano Padial Sabino
• Grantee: Caetano Padial Sabino
• Company: BioLambda Científica e Comercial Ltda. - EPP
• CNAE: Fabricação de aparelhos eletromédicos e eletroterapêuticos e equipamentos de irradiação ; Fabricação de equipamentos e instrumentos ópticos, fotográficos e cinematográficos ; Atividades profissionais, científicas e técnicas não especificadas anteriormente
• City: São Paulo
• Pesquisadores principais: Arthur Padial Nogueira ; Henrique Forlani Masini ; José Tort Vidal ; Ricardo Marques da Silva Martins Guimarães ; Thiago Maximino de Menezes Passos
• Associated researchers: Aguinaldo Silva Garcez Segundo ; Cleber Ferraresi ; Fabio Celidonio Pogliani ; Fábio Parra Sellera ; Ilka Tiemy Kato Prates ; João Paulo Tardivo ; Laura Marise de Freitas ; Martha Simões Ribeiro ; Mauricio da Silva Baptista ; Niklaus Ursus Wetter ; Nilton Erbet Lincopan Huenuman ; Nivaldo Antonio Parizotto ; Renato Araujo Prates ; Rodrigo Crespo Mosca ; Rosangela Itri ; Selly Sayuri Suzuki ; Silvia Cristina Núñez
• Associated scholarship(s): 19/05177-2 - Leadership, planning and programming of firmware, software, online server and web application dedicated to clinical phototherapy equipment, BP.TT; 19/05933-1 - Development of intelligent equipment for clinical application of phototherapies with automatic dosimetric adjustment and payment on demand, BP.TT; 19/02702-9 - Development of mechanical components and technical adaptations for development of equipment for clinical application of phototherapies, BP.TT

Abstract

Photobiomodulation (PBM) and photodynamic therapy (PDT) have been reported as viable strategies for the treatment of numerous diseases. However, the success rate of the treatments directly depends on the complex dosimetric analysis of optical parameters that limit its ease of use. Commercially available clinical systems are capable of covering and performing dosimetric calibrations limited to specific lesion areas and require physical contact between the irradiator and the patient. Also, current equipment do not have internet connection and therefore do not allow software, suggested protocols or usage log updates. Our irradiators will be equipped with microprocessors programmed with sufficient information to allow automated recognition and dosimetry calculation immediately after connection with the controller device. The irradiator for large areas will be equipped with a known optical divergence system and distance sensors to enable the irradiation of large lesions without physical contact and to automatically perform the dosimetric calculation adjusted to the distance. The controller module will be programmed using python and bash scripts together to operate the integrated digital board with graphical interface at the firmware level. The software updates and usage records of the equipment will be carried out by Wi-Fi communication with a cloud server, which will be accessed through a online application that will be available on our company website. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SABINO, CAETANO P.; BALL, ANTHONY R.; BAPTISTA, MAURICIO S.; DAI, TIANHONG; HAMBLIN, MICHAEL R.; RIBEIRO, MARTHA S.; SANTOS, ANA L.; SELLERA, FABIO P.; TEGOS, GEORGE P.; WAINWRIGHT, MARK. Light-based technologies for management of COVID-19 pandemic crisis. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 212, NOV 2020. (17/22406-0, 13/07937-8)

DOS ANJOS, CAROLINA; SABINO, CAETANO P.; SELLERA, FABIO P.; ESPOSITO, FERNANDA; POGLIANI, FABIO C.; LINCOPAN, NILTON. Hypervirulent and hypermucoviscous strains of Klebsiella pneumoniae challenged by antimicrobial strategies using visible light. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 56, n. 1, JUL 2020. (19/10851-4, 16/25095-2, 19/15578-4, 17/22406-0)

SABINO, CAETANO P.; WAINWRIGHT, MARK; DOS ANJOS, CAROLINA; SELLERA, FABIO P.; BAPTISTA, MAURICIO S.; LINCOPAN, NILTON; RIBEIRO, MARTHA S.. Inactivation kinetics and lethal dose analysis of antimicrobial blue light and photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 28, p. 186-191, DEC 2019. (17/22406-0, 13/07937-8, 16/08593-9)

SABINO, CAETANO PADIAL; WAINWRIGHT, MARK; RIBEIRO, MARTHA SIMOES; SELLERA, FABIO PARRA; DOS ANJOS, CAROLINA; BAPTISTA, MAURICIO DA SILVA; LINCOPAN, NILTON. Global priority multidrug-resistant pathogens do not resist photodynamic therapy. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 208, JUL 2020. (16/08593-9, 17/22406-0, 13/07937-8, 16/25095-2)

RIBEIRO, MARTHA S.; SABINO, CAETANO P.; NUNEZ, SILVIA CRISTINA; HASAN, T. Antimicrobial photodynamic therapy: from basis to clinical applications. 17TH INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, v. 11070, p. 9-pg., 2019-01-01. (10/13313-9, 05/01756-5, 17/22406-0)

DOS ANJOS, CAROLINA; SELLERA, FABIO P.; RIBEIRO, MARTHA S.; BAPTISTA, MAURICIO S.; POGLIANI, FABIO C.; LINCOPAN, NILTON; SABINO, CAETANO P.. Antimicrobial blue light and photodynamic therapy inhibit clinically relevant 8-lactamases with extended-spectrum (ESBL) and carbapenemase activity. Photodiagnosis and Photodynamic Therapy, v. 32, DEC 2020. (16/25095-2, 19/10851-4, 17/22406-0)

SABINO, CAETANO P.; SELLERA, FABIO P.; SALES-MEDINA, DOUGLAS F.; GUARAGNA MACHADO, RAFAEL RAHAL; DURIGON, EDISON LUIZ; FREITAS-JUNIOR, LUCIO H.; RIBEIRO, MARTHA S.. UV-C (254 nm) lethal doses for SARS-CoV-2. Photodiagnosis and Photodynamic Therapy, v. 32, DEC 2020. (17/24769-2, 17/22406-0, 16/20045-7)

SABINO, CAETANO P.; RIBEIRO, MARTHA S.; WAINWRIGHT, MARK; DOS ANJOS, CAROLINA; SELLERA, FABIO P.; DROPA, MILENA; NUNES, NATHALIA B.; BRANCINI, GUILHERME T. P.; BRAGA, GILBERTO U. L.; ARANA-CHAVEZ, VICTOR E.; et al. The Biochemical Mechanisms of Antimicrobial Photodynamic Therapy(1). Photochemistry and Photobiology, v. N/A, p. 9-pg., 2022-08-12. (16/25095-2, 17/22406-0, 16/08593-9, 13/07937-8, 19/10851-4)