Development and characterization of Liquid Crystal Emulsions and Pickering emulsions for ascorbic acid

• Grant number: 18/06973-4
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2019
• End date: April 30, 2021
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Gislaine Ricci Leonardi
• Grantee: Gislaine Ricci Leonardi
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Karin Do Amaral Riske

Abstract

Ascorbic acid (AA) is a potent antioxidant, capable of acting in prevention and treatment of the skin aging. However, in order to present therapeutic efficacy, AA should be kept stable and reach the active site. Although the scientific literature contains several studies using different mechanisms for the delivery of AA, the results obtained are limited and there is a shortage of publications comparing the effectiveness of systems in their delivery capacity. So, the development of stable formulations that allow viable permeation of AA in the skin remains challenging. Here, we propose the development of Liquid Crystal Emulsions and emulsions stabilized by solid particles, free of surfactants, also called Pickering emulsions for the delivery of AA. All the systems will be characterized by numerous methodologies, aiming to clarify the relationship between the physicochemical characteristics of the formulations and the release of the molecule of interest. Skin permeation tests will also be performed in order to compare the delivery effectiveness of different systems. Finally, one of the delivery systems studied will be selected to verify the effect of topical application of ascorbic acid compared to placebo using High-Frequency Ultrasound (22 and 75 MHz) in order to investigate the action of this active of epidermal thickness and dermal density and echogenicity. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VERGILIO, MARIANE MASSUFERO; SILVA, SILAS ARANDAS MONTEIRO E; VASQUES, LOUISE IDALGO; LEONARDI, GISLAINE RICCI. Characterization of women's young and mature skin by the 50 MHz high-frequency ultrasound technique. Journal of Cosmetic Dermatology, MAR 2021. (18/06973-4)

AIELLO, LAURA MORETTI; VERGILIO, MARIANE MASSUFERO; SILVA, SILAS ARANDAS MONTEIRO E; ANSELMO, TAMIRIS; LEONARDI, GISLAINE RICCI. Skin effect of facial cleansing combined with an electric sonic device. Journal of Cosmetic Dermatology, MAR 2021. (18/06973-4)

VERGILIO, MARIANE MASSUFERO; VASQUES, LOUISE IDALGO; LEONARDI, GISLAINE RICCI. Characterization of skin aging through high-frequency ultrasound imaging as a technique for evaluating the effectiveness of anti-aging products and procedures: A review. SKIN RESEARCH AND TECHNOLOGY, v. 27, n. 5, p. 966-973, SEP 2021. (18/06973-4)

AIELLO, LAURA MORETTI; VERGILIO, MARIANE MASSUFERO; SILVA, SILAS ARANDAS MONTEIRO E; ANSELMO, TAMIRIS; LEONARDI, GISLAINE RICCI. Skin effect of facial cleansing combined with an electric sonic device. Journal of Cosmetic Dermatology, v. 20, n. 11, p. 3537-3544, NOV 2021. (18/06973-4)

VERGILIO, MARIANE MASSUFERO; AIELLO, LAURA MORETTI; FURLAN, ANDREZA SONEGO; CARITA, AMANDA COSTA; AZEVEDO, JAQUELINE REZENDE; BOLZINGER, MARIE-ALEXANDRINE; CHEVALIER, YVES; LEONARDI, GISLAINE RICCI. In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound. Journal of Cosmetic Dermatology, v. 21, n. 10, p. 6-pg., 2022-03-14. (18/06973-4)

CARITA, AMANDA C.; DE AZEVEDO, JACQUELINE RESENDE; CHEVALIER, YVES; ARQUIER, DELPHINE; BURI, MARCUS, V; RISKE, KARIN A.; LEONARDI, GISLAINE RICCI; BOLZINGER, MARIE-ALEXANDRINE. Elastic cationic liposomes for vitamin C delivery: Development, characterization and skin absorption study. International Journal of Pharmaceutics, v. 638, p. 11-pg., 2023-04-07. (18/06973-4, 16/13368-4)

VERGILIO, MARIANE MASSUFERO; VASQUES, LOUISE IDALGO; LEONARDI, GISLAINE RICCI. Characterization of skin aging through high-frequency ultrasound imaging as a technique for evaluating the effectiveness of anti-aging products and procedures: A review. SKIN RESEARCH AND TECHNOLOGY, MAR 2021. (18/06973-4)

CARITA, AMANDA C.; DE AZEVEDO, JACQUELINE RESENDE; BURI, MARCUS VINICIUS; BOLZINGER, MARIE-ALEXANDRINE; CHEVALIER, YVES; RISKE, KARIN A.; LEONARDI, GISLAINE RICCI. Stabilization of vitamin C in emulsions of liquid crystalline structures. International Journal of Pharmaceutics, v. 592, JAN 5 2021. (16/13368-4, 18/06973-4)

VERGILIO, MARIANE MASSUFERO; SILVA, SILAS ARANDAS; JALES, RODRIGO MENEZES; LEONARDI, GISLAINE RICCI. High-frequency ultrasound as a scientific tool for skin imaging analysis. EXPERIMENTAL DERMATOLOGY, v. 30, n. 7, p. 897-910, JUL 2021. (18/06973-4)

VERGILIO, MARIANE MASSUFERO; SILVA, SILAS ARANDAS MONTEIRO E; VASQUES, LOUISE IDALGO; LEONARDI, GISLAINE RICCI. Characterization of women's young and mature skin by the 50 MHz high-frequency ultrasound technique. Journal of Cosmetic Dermatology, v. 20, n. 11, p. 3695-3697, NOV 2021. (18/06973-4)