Effect of HPV infection and inflammatory mediators on epithelial-mesenchymal transition

• Grant number: 18/15468-1
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2019
• End date: June 30, 2021
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Eloiza Helena Tajara da Silva
• Grantee: Eloiza Helena Tajara da Silva
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
• Associated researchers: Laura Cristina Sichero Vettorazzo ; Nelson José Freitas da Silveira ; Tiago Henrique

Abstract

Head and neck squamous cell carcinomas of the head and neck (HNSCC) comprise one of the best examples of neoplasms that occur in a context of inflammation caused by infections or other etiological agents, such as tobacco and alcohol. HNSCCs associated with human papillomavirus (HPV) infection have a better prognosis than HPV negative HNSCCs, probably because the latter have high genomic instability. The expression profile of HPV negative has also revaled markers of epithelial-mesenchymal transition (EMT), cell motility, invasiveness and angiogenesis, whereas HPV positive ones are characterized by cell cycle and proliferation alterations. The overall objective of this project is to investigate the mechanisms by which EMT is activated by HPV infection and by mediators of inflammation, as well as to identify new potential inhibitors for EMT markers. (AU)